ବେକ୍ଲୋମେଟାଜୋନ ଡାଇପ୍ରୋପିଓନେଟ

ବେକ୍ଲୋମେଟାଜୋନ ଡାଇପ୍ରୋପିଓନେଟ (INN modified)
Clinical data
Trade names	Qvar, Beconase AQ, others
AHFS/Drugs.com	monograph
MedlinePlus	a681047
Pregnancy; category	AU: B3 ; ;
Routes of; administration	Oral inhalation, nasal inhalation, topical
ATC code	A07EA07 (WHO) D07AC15, R01AD01, R03BA01;
Legal status
Legal status	AU: S2 (Pharmacy only) ; UK: Prescription-only (POM), but some nasal sprays are General sales list (GSL, OTC) ;
Pharmacokinetic data
Bioavailability	Converted to beclometasone-17-monopropionate (17-BMP) during absorption
Protein binding	87% of 17-BMP to albumin and transcortin
Metabolism	By esterase enzymes found in most tissues
Elimination half-life	2.8 hours
Excretion	Biliary (60%), renal (12%)
Identifiers
	IUPAC name (8S,9R,10S,11S,13S,14S,16S,17R)-9-chloro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-[2-(propionyloxy)acetyl]-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate;
CAS Number	5534-09-8 ;
PubChem CID	21700;
IUPHAR/BPS	5894;
DrugBank	DB00394 ;
ChemSpider	20396 ;
UNII	5B307S63B2;
ChEBI	CHEBI:3002 ;
ChEMBL	CHEMBL1200500 ;
ECHA InfoCard	100.024.442
Chemical and physical data
Formula	C28H37ClO7
Molar mass	521.042 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(Cl)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C)CC;
	InChI InChI=1S/C28H37ClO7/c1-6-23(33)35-15-22(32)28(36-24(34)7-2)16(3)12-20-19-9-8-17-13-18(30)10-11-25(17,4)27(19,29)21(31)14-26(20,28)5/h10-11,13,16,19-21,31H,6-9,12,14-15H2,1-5H3/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1 ; Key:KUVIULQEHSCUHY-XYWKZLDCSA-N ;
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ବେକ୍ଲୋମେଟାଜୋନ ଡାଇପ୍ରୋପିଓନେଟ ବା ବେକ୍ଲୋମେଥାଜୋନ ଡାଇପ୍ରୋପିଓନେଟ ଏକ ସ୍ଟିରଏଡ ଔଷଧ ।^[୧] ଏହା ଇନହେଲର, କ୍ରିମ, ପିଲ ଓ ନାକ ସ୍ଟ୍ରେ ଆକାରରେ ମିଳେ ।^[୨]ଆଜ୍‌ମା ରୋଗର ଦୀର୍ଘକାଳୀନ ଚିକିତ୍ସା ନିମନ୍ତେ ଏହା ଦିଆଯାଏ ।^[୧] ଡର୍ମାଟାଇଟିସ ଓ ସୋରିଆସିସ ରୋଗରେ ଏହା କ୍ରିମ ଆକାରରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୩] ଅଲସରେଟିଭ କୋଲାଇଟିସ ରୋଗରେ ପିଲ ଦିଆଯାଏ ।^[୪] ଆରର୍ଜିକ ରାଇନାଇଟିସ ଓ ନାଜାଲ ପଲିପ ଥିଲେ ନାକ ସ୍ପ୍ରେ ଦିଆଯାଏ ।^[୫]

ଏହାର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା: ଅନ୍ତଶୋଷକ ଯୋଗୁ ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ, ମୁଣ୍ଡବଥା ଓ ତଣ୍ଟି ପ୍ରଦାହ ହୋଇପାରେ । ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା: ପରଳ, କୁସିଙ୍ଗ ସିଣ୍ଡ୍ରୋମ ଓ ଆନାଫାଇଲାକ୍‌ସିସଇତ୍ୟାଦି ହୋଇପାରେ । ^[୧] ପିଲର ଦୀର୍ଘକାଳୀନ ବ୍ୟବ‌ହାର ଯୋଗୁ ଆଡ୍ରେନାଲ ଅଭାବ ଦେଖାଯାଏ ।^[୪] ଏହା ବ୍ୟତୀତ ମନୋଭାବ ଓ ବ୍ୟକ୍ତିତ୍ୱ ପରିବର୍ତ୍ତନ ହୋଇପାରେ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ଅନ୍ତଶୋଷକ ସାଧାରଣତଃ ନିରାପଦ ଥାଏ ।^[୬] ବେକ୍ଲୋମେଟାଜୋନ ଏକ ପ୍ରକାର ଗ୍ଲୁକୋକର୍ଟିକଏଡ ।^[୧]

ସନ ୧୯୬୨ରେ ବେକ୍ଲୋମେଟାଜୋନ ଡାଇପ୍ରୋପିଓନେଟ ପ୍ରଥମେ ପେଟେଣ୍ଟ ହୋଇ ସନ ୧୯୭୨ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବ‌ହୃତ ହେଲା ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଏହା ସନ ୧୯୭୬ରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୧] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୮] ୨୦୦ ଡୋଜ ଥିବା ଇନହେଲର ମୂଲ୍ୟ ସନ ୨୦୧୪ରେ ପ୍ରାୟ ୩.୨୦ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୯] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏକ ମାସ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ୫୦ରୁ ୧୦୦ ଡଲାର ମୂଲ୍ୟ ଦେବାକୁ ହୁଏ ।^[୧୦]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Beclomethasone Dipropionate". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.
↑ "List of products: BECLOMETASONE DIPROPIONATE". MHRA. Retrieved 6 December 2015.
↑ "Beclometasone dipropionate 0.25 mg/g Cream" (PDF). MHRA. Archived from the original (PDF) on 8 December 2015. Retrieved 6 December 2015.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Clipper" (PDF). MHRA. Archived from the original (PDF) on 8 December 2015. Retrieved 6 December 2015.
↑ "Beclomethasone Dipropionate eent". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 349. ISBN 9781284057560.
↑ McPherson, Edwin M. (2007). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Burlington: Elsevier. p. 539. ISBN 9780815518563.
↑ "WHO Model List of Essential Medicines" (PDF). Apps.WHO.int. World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Beclometasone". International Drug Price Indicator Guide. Retrieved 6 December 2015.^{[permanent dead link]}
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 451. ISBN 9781284057560.

[AHFS2015-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Beclomethasone Dipropionate". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.

[MHRA2015-2] "List of products: BECLOMETASONE DIPROPIONATE". MHRA. Retrieved 6 December 2015.

[3] "Beclometasone dipropionate 0.25 mg/g Cream" (PDF). MHRA. Archived from the original (PDF) on 8 December 2015. Retrieved 6 December 2015.

[MHRA2015Pill-4] ୪.୦ ^୪.୧ ^୪.୨ "Clipper" (PDF). MHRA. Archived from the original (PDF) on 8 December 2015. Retrieved 6 December 2015.

[AHFS2015ENT-5] "Beclomethasone Dipropionate eent". The American Society of Health-System Pharmacists. Retrieved Dec 2, 2015.

[Ric2015a-6] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 349. ISBN 9781284057560.

[7] McPherson, Edwin M. (2007). Pharmaceutical Manufacturing Encyclopedia (3rd ed.). Burlington: Elsevier. p. 539. ISBN 9780815518563.

[8] "WHO Model List of Essential Medicines" (PDF). Apps.WHO.int. World Health Organization. October 2013. Retrieved 22 April 2014.

[9] "Beclometasone". International Drug Price Indicator Guide. Retrieved 6 December 2015.^{[permanent dead link]}

[Ric2015b-10] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 451. ISBN 9781284057560.

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