ଅକ୍ସକାର୍ବାଜେପିନ

ଅକ୍ସକାର୍ବାଜେପିନ
Clinical data
Pronunciation	/ɒks.kɑːrˈbæz.ɪˌpiːn/
Trade names	Trileptal, Oxtellar XR, others
AHFS/Drugs.com	monograph
MedlinePlus	a601245
data	US DailyMed: Oxcarbazepine;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth (tablets or liquid)
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	>95%
Metabolism	Liver (cytosolic enzymes and glucuronic acid)
Elimination half-life	1–5 hours (healthy adults)
Excretion	Kidney (<1%)
Identifiers
	IUPAC name 10,11-dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;
ECHA InfoCard	100.044.702
Chemical and physical data
Formula	C15H12N2O2
Molar mass	୨୫୨.୨୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C3c1c(cccc1)N(c2ccccc2C3)C(=O)N;
	InChI InChI=1S/C15H12N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8H,9H2,(H2,16,19) ; Key:CTRLABGOLIVAIY-UHFFFAOYSA-N ;
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ଅକ୍ସକାର୍ବାଜେପିନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବ୍ୟବସାୟୀକ ନାମ ଟ୍ରାଇଲେପ୍ଟାଲ, ଏକ ଔଷଧ ଯାହା ଅପସ୍ମାର ଏବଂ ବାଇପୋଲାର ଡିଜଅର୍ଡ଼ର ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୨] ଏହା ଉଭୟ ସ୍ଥାନୀୟ ଓ ସାଧାରଣ ଧରଣର ଅପସ୍ମାର ପାଇଁ ଦିଆଯାଏ | ^[୩] ବାଇପୋଲାର ଡିଜଅର୍ଡ଼ର ରୋଗରେ ଯେଉଁ ରୋଗୀମାନେ ଅନ୍ୟ କୌଣସି ଚିକିତ୍ସାରେ ସଫଳତା ପାଇନାହାଁନ୍ତି ସେମାନଙ୍କୁ ଏହା ଏକାକୀ ବା ମିଶ୍ରିତ ଭାବରେ ଦିଆଯାଉଛି, | ^[୪] ^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ବାନ୍ତି, ମୁଣ୍ଡ ବୁଲାଇବା, ନିଦ୍ରାହୀନତା, ଦ୍ୱିତ ଦୃଷ୍ଟି ଏବଂ ଚାଲିବାରେ ଅସୁବିଧା ହୋଇପାରେ | ^[୬] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ, ଯକୃତ ସମସ୍ୟା, ଅଗ୍ନାଶୟ ପ୍ରଦାହ, ଆତ୍ମହତ୍ୟା ଏବଂ ଏକ ଅସ୍ୱାଭାବିକ ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ ହୋଇପାରେ | ^[୭] ^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ କିନ୍ତୁ ବାତ ଅପେକ୍ଷା ଏହାର ବ୍ୟବହାର କମ୍ ବିପଦଜନକ ହୋଇପାରେ | ^[୮] ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୯] କାର୍ବାମାଜେପିନ ପ୍ରତି ଆଲର୍ଜି ଥିବା ବ୍ୟକ୍ତିଙ୍କଠାରେ ଅକ୍ସକାର୍ବାଜେପିନ ୨୫% ସମସ୍ୟା ହେବାର ଆଶଙ୍କା ଥାଏ | ^[୭] ଏହା କିପରି କାମ କରେ ତାହା ସଂପୂର୍ଣ୍ଣ ସ୍ପଷ୍ଟ ନୁହେଁ | ^[୨]

ଅକ୍ସକାର୍ବାଜେପିନ ୧୯୬୯ରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୦ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା |^[୧୦] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସର ଯୋଗାଣ ୨୦୧୯ ମସିହା ସୁଦ୍ଧା ପ୍ରାୟ ୬.୫୦ ପାଉଣ୍ଡ ଅଟେ। ^[୩] ^[୧୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୭.୧୫ ଡଲାର ଅଟେ। ^[୧୨] ୨୦୧୭ରେ ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୭ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଦୁଇ ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ ରହିଥିଲା | ^[୧୩] ^[୧୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Oxcarbazepine Drug Label". Archived from the original on 2015-12-08. Retrieved 2015-11-04.
↑ ^୨.୦ ^୨.୧ "Oxcarbazepine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 30 March 2019. Retrieved 13 April 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 319–320. ISBN 9780857113382.
↑ Mazza M, Di Nicola M, Martinotti G, Taranto C, Pozzi G, Conte G, Janiri L, Bria P, Mazza S (April 2007). "Oxcarbazepine in bipolar disorder: a critical review of the literature". Expert Opinion on Pharmacotherapy. 8 (5): 649–56. doi:10.1517/14656566.8.5.649. PMID 17376019.
↑ ^୫.୦ ^୫.୧ "Oxcarbazepine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 30 March 2019. Retrieved 13 April 2019.
↑ "DailyMed - OXCARBAZEPINE- oxcarbazepine tablet". dailymed.nlm.nih.gov. Archived from the original on 2015-12-08. Retrieved 2015-11-11.
↑ ^୭.୦ ^୭.୧ "DailyMed - OXCARBAZEPINE- oxcarbazepine tablet". dailymed.nlm.nih.gov. Archived from the original on 2015-12-08. Retrieved 2015-11-11.
↑ "Oxcarbazepine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 13 April 2019. Retrieved 13 April 2019.
↑ "Oxcarbazepine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 13 April 2019. Retrieved 13 April 2019.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 532. ISBN 9783527607495. Archived from the original on 2019-03-06. Retrieved 2019-03-02.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 319–320. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019. Archived 2019-03-06 at the Wayback Machine.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Oxcarbazepine - Drug Usage Statistics". ClinCalc. Archived from the original on 28 February 2020. Retrieved 11 April 2020.

[OxcarbPI-1] ୧.୦ ^୧.୧ "Oxcarbazepine Drug Label". Archived from the original on 2015-12-08. Retrieved 2015-11-04.

[AHFS2019-2] ୨.୦ ^୨.୧ "Oxcarbazepine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 30 March 2019. Retrieved 13 April 2019.

[BNF76-3] ୩.୦ ^୩.୧ ^୩.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 319–320. ISBN 9780857113382.

[Mazza_2007-4] Mazza M, Di Nicola M, Martinotti G, Taranto C, Pozzi G, Conte G, Janiri L, Bria P, Mazza S (April 2007). "Oxcarbazepine in bipolar disorder: a critical review of the literature". Expert Opinion on Pharmacotherapy. 8 (5): 649–56. doi:10.1517/14656566.8.5.649. PMID 17376019.

[autogen5-5] ୫.୦ ^୫.୧ "Oxcarbazepine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Archived from the original on 30 March 2019. Retrieved 13 April 2019.

[Daily2015-6] "DailyMed - OXCARBAZEPINE- oxcarbazepine tablet". dailymed.nlm.nih.gov. Archived from the original on 2015-12-08. Retrieved 2015-11-11.

[autogen1-7] ୭.୦ ^୭.୧ "DailyMed - OXCARBAZEPINE- oxcarbazepine tablet". dailymed.nlm.nih.gov. Archived from the original on 2015-12-08. Retrieved 2015-11-11.

[Preg2019-8] "Oxcarbazepine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 13 April 2019. Retrieved 13 April 2019.

[autogen4-9] "Oxcarbazepine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 13 April 2019. Retrieved 13 April 2019.

[Fis2006-10] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 532. ISBN 9783527607495. Archived from the original on 2019-03-06. Retrieved 2019-03-02.

[autogen2-11] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 319–320. ISBN 9780857113382.

[NADAC2019-12] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019. Archived 2019-03-06 at the Wayback Machine.

[ref-13] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[ref1-14] "Oxcarbazepine - Drug Usage Statistics". ClinCalc. Archived from the original on 28 February 2020. Retrieved 11 April 2020.

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