ଇମିପ୍ରାମିନ

ଇମିପ୍ରାମିନ
Clinical data
Trade names	Tofranil, Tofranil-PM, others
Synonyms	Imipramine hydrochloride, melipramine; G-22355
AHFS/Drugs.com	monograph
MedlinePlus	a682389
data	US DailyMed: Imipramine;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth, intramuscular injection
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	94–96%
Protein binding	86%
Metabolism	Liver (CYP1A2, CYP2C19, CYP2D6)
Metabolites	Desipramine
Elimination half-life	20 hours
Excretion	Kidney (80%), fecal (20%)
Identifiers
	IUPAC name 3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine;
ECHA InfoCard	100.000.039
Chemical and physical data
Formula	C19H24N2
Molar mass	୨୮୦.୪୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31;
	InChI InChI=1S/C19H24N2/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21/h3-6,8-11H,7,12-15H2,1-2H3 ; Key:BCGWQEUPMDMJNV-UHFFFAOYSA-N ;
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ଇମିପ୍ରାମିନ, ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଟ୍ରାଇସାଇକ୍ଲିକ୍ ଆଣ୍ଟିଡେପ୍ରେସାଣ୍ଟ (TCA) ଔଷଧ ଯାହା ଅବସାଦ, ପ୍ୟାନିକ୍ ଡିଜଅର୍ଡର, ବିଛଣା ମୂତ୍ରତ୍ୟାଗଏବଂ ପୋଷ୍ଟରପେଟିକ୍ ନ୍ୟୁରାଲଜିଆ ସହିତ ଉଦ୍‌ବେଗ ଅବ୍ୟବସ୍ଥା ରୋଗମାନାଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି, ନିଦ୍ରାଳୁ, କୋଷ୍ଠକାଠିନ୍ୟ, ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି ଏବଂ ଛିଡା ହେବା ସହିତ ନିମ୍ନ ରକ୍ତଚାପ ହୋଇପାରେ ।^[୫] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମାନିଆ, ଆତପଦାହ, ବାତ ଏବଂ ଆତ୍ମହତ୍ୟା ହୋଇପାରେ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ । ^[୬] ଏହା କିପରି କାର୍ଯ୍ୟ କରେ ତାହା ସ୍ପଷ୍ଟ ନୁହେଁ କିନ୍ତୁ ସେରୋଟୋନିନ ଏବଂ ନର୍-ଏପିନେଫ୍ରିନ ସ୍ତର ବୃଦ୍ଧି ସ‌ହିତ ସମ୍ପର୍କ ଥାଇପାରେ ।^[୫]

ଇମିପ୍ରାମିନ ୧୯୫୧ ମସିହାରେ ଆବିଷ୍କୃତ ହୋଇଥିଲା ଏବଂ ୧୯୫୯ ମସିହାରେ ଡାକ୍ତରୀ ଚିକିତ୍ସାର ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୭] ଏହା ପ୍ରଥମ ଟିସିଏ (TCA) ଭାବରେ ବିକ୍ରୟ ହୋଇଥିଲା ।^[୮] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ଯୁକ୍ତରାଜ୍ୟରେ ୨୫ ମିଗ୍ରାର ୪ ସପ୍ତାହର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ £୭ ଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୦ ଡଲାର ଅଟେ। ।^[୯]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Imipramine Use During Pregnancy". Drugs.com. 28 August 2019. Archived from the original on 7 February 2020. Retrieved 7 February 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Product Information Tolerade (imipramine hydrochloride)". TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013. Archived from the original on 10 December 2019. Retrieved 16 October 2013.
↑ Heck HA, Buttrill SE Jr, Flynn NW, Dyer RL, Anbar M, Cairns T, Dighe S, Cabana BE (June 1979). "Bioavailability of imipramine tablets relative to a stable isotope-labelled internal standard: increasing the power of bioavailability tests". Journal of Pharmacokinetics and Biopharmaceutics. 7 (3): 233–248. doi:10.1007/bf01060015. PMID 480146. S2CID 23232584.{{cite journal}}: CS1 maint: multiple names: authors list (link)
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 397. ISBN 978-0857114105.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Imipramine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 26 November 2021.
↑ "Imipramine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 February 2020. Retrieved 26 November 2021.
↑ Walker, S. R. (6 December 2012). Trends and Changes in Drug Research and Development (in ଇଂରାଜୀ). Springer Science & Business Media. p. 109. ISBN 978-94-009-2659-2. Archived from the original on 14 September 2016. Retrieved 26 November 2021.
↑ "imipramine | Uses, Mechanism of Action, & Side Effects | Britannica". www.britannica.com (in ଇଂରାଜୀ). Archived from the original on 8 November 2021. Retrieved 26 November 2021.
↑ "Imipramine Hydrochloride Prices and Imipramine Hydrochloride Coupons - GoodRx". GoodRx. Retrieved 26 November 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Imipramine Use During Pregnancy". Drugs.com. 28 August 2019. Archived from the original on 7 February 2020. Retrieved 7 February 2020.

[Tolerade-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Product Information Tolerade (imipramine hydrochloride)". TGA eBusiness Services. PMIP Pty Ltd. 4 June 2013. Archived from the original on 10 December 2019. Retrieved 16 October 2013.

[Pharm-3] Heck HA, Buttrill SE Jr, Flynn NW, Dyer RL, Anbar M, Cairns T, Dighe S, Cabana BE (June 1979). "Bioavailability of imipramine tablets relative to a stable isotope-labelled internal standard: increasing the power of bioavailability tests". Journal of Pharmacokinetics and Biopharmaceutics. 7 (3): 233–248. doi:10.1007/bf01060015. PMID 480146. S2CID 23232584.{{cite journal}}: CS1 maint: multiple names: authors list (link)

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 397. ISBN 978-0857114105.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Imipramine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 January 2021. Retrieved 26 November 2021.

[6] "Imipramine Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 7 February 2020. Retrieved 26 November 2021.

[7] Walker, S. R. (6 December 2012). Trends and Changes in Drug Research and Development (in ଇଂରାଜୀ). Springer Science & Business Media. p. 109. ISBN 978-94-009-2659-2. Archived from the original on 14 September 2016. Retrieved 26 November 2021.

[8] "imipramine | Uses, Mechanism of Action, & Side Effects | Britannica". www.britannica.com (in ଇଂରାଜୀ). Archived from the original on 8 November 2021. Retrieved 26 November 2021.

[9] "Imipramine Hydrochloride Prices and Imipramine Hydrochloride Coupons - GoodRx". GoodRx. Retrieved 26 November 2021.

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