ଆଟୋମେକ୍ସେଟିନ

ଆଟୋମେକ୍ସେଟିନ
Clinical data
Trade names	Strattera, others
Synonyms	(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine
AHFS/Drugs.com	monograph
MedlinePlus	a603013
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
ATC code	N06BA09 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	63 to 94%
Protein binding	98%
Metabolism	Liver, via CYP2D6
Elimination half-life	4.5-19 hours
Excretion	Kidney (80%) and faecal (17%)
Identifiers
	IUPAC name (3R)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine;
CAS Number	83015-26-3 ;
PubChem CID	54841;
IUPHAR/BPS	7118;
DrugBank	DB00289 ;
ChemSpider	49516 ;
UNII	ASW034S0B8;
KEGG	D07473 ;
ChEBI	CHEBI:127342 ;
ChEMBL	CHEMBL641 ;
ECHA InfoCard	100.120.306
Chemical and physical data
Formula	C17H21NO
Molar mass	255.36 g/mol; 291.81 g/mol (hydrochloride)
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C=CC=C1)O[C@H](CCNC)C2=CC=CC=C2;
	InChI InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1 ; Key:VHGCDTVCOLNTBX-QGZVFWFLSA-N ;
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ଆଟୋମେକ୍ସେଟିନ (ଇଂରାଜୀ ଭାଷାରେ Atomoxetine, ଏକ ବିକ୍ରୟ ନାମ ସ୍ଟ୍ରାଟେରା/ Strattera) ଏକ ଔଷଧ ଯାହା ଧ୍ୟାନାଭାବ ଓ ଅତିସକ୍ରିୟତା ବିକାର (ADHD) ରୋଗର ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୫] ଅତି କମ୍‌ରେ ଏହାର ବ୍ୟବ‌ହାର ନିମନ୍ତେ ରୋଗୀର ବୟସ ୬ ବର୍ଷ ବା ଅଧିକ ହେବା ଆବଶ୍ୟକ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୫]

ଆଟୋମେକ୍ସେଟିନର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଦର ଯନ୍ତ୍ରଣା, ଅରୁଚି, ଅଇ, ଥକ୍କା ଅନୁଭବ ଓ ମୁଣ୍ଡ ଓଜନିଆ ଲାଗିପାରେ । ^[୫] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ଆଞ୍ଜିଓଇଡିମା, ଯକୃତ ସମସ୍ୟା, ସ୍ଟ୍ରୋକ, ସାଇକୋସିସ, ହୃତପିଣ୍ଡ ସମସ୍ୟା, ଆତ୍ମହତ୍ୟା ପ୍ରବଣ ଓ ଆକ୍ରମଣାତ୍ମକ ବ୍ୟବ‌ହାର ଦେଖାଯାଇପାରେ ।^[୫]^[୬] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ (breastfeeding) ସମୟରେ ଏହାର ପ୍ରତିକ୍ରିୟା ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୭] ଆଟୋମେକ୍ସେଟିନ ଏକ ନରେପିନେଫ୍ରିନ ରିଅପଟେକ ଇନହିବିଟର (norepinephrine reuptake inhibitor) ଭାବରେ କାମ କରେ । ^[୫]

ସନ ୨୦୦୨ରେ ଆଟୋମେକ୍ସେଟିନ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୫] ସନ ୨୦୧୯ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ଏହାର ଏକ ମାସର ଡୋଜ ପିଛା ପ୍ରାୟ ୫୩ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୭୭ ଆମେରିକୀୟ ଡଲାର ।^[୮] ସନ ୨୦୧୬ରେ ଏହାର ୨ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିସନ ତାଲିକାର ୨୪୫ତମ ସ୍ଥାନରେ ଥଲା ।^[୯]

ଏହ ମଧ୍ୟ ଦେଖନ୍ତୁ

Serotonin-norepinephrine reuptake inhibitors

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "atomoxetine (Rx) – Strattera". Medscape Reference. WebMD. Retrieved 10 November 2013.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "STRATTERA® (atomoxetine hydrochloride)". TGA eBusiness Services. Eli Lilly Australia Pty. Limited. 21 August 2013. Retrieved 10 November 2013.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "ATOMOXETINE HYDROCHLORIDE capsule [Mylan Pharmaceuticals Inc.]". DailyMed. Mylan Pharmaceuticals Inc. October 2011. Retrieved 10 November 2013.
↑ Sauer, JM; Ring, BJ; Witcher, JW (2005). "Clinical pharmacokinetics of atomoxetine". Clinical Pharmacokinetics. 44 (6): 571–90. doi:10.2165/00003088-200544060-00002. PMID 15910008.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ "Atomoxetine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 22 March 2019.
↑ ^୬.୦ ^୬.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 344–345. ISBN 9780857113382.
↑ "Atomoxetine Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

[MSR-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "atomoxetine (Rx) – Strattera". Medscape Reference. WebMD. Retrieved 10 November 2013.

[TGA-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "STRATTERA® (atomoxetine hydrochloride)". TGA eBusiness Services. Eli Lilly Australia Pty. Limited. 21 August 2013. Retrieved 10 November 2013.

[DM-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ "ATOMOXETINE HYDROCHLORIDE capsule [Mylan Pharmaceuticals Inc.]". DailyMed. Mylan Pharmaceuticals Inc. October 2011. Retrieved 10 November 2013.

[PMID15910008-4] Sauer, JM; Ring, BJ; Witcher, JW (2005). "Clinical pharmacokinetics of atomoxetine". Clinical Pharmacokinetics. 44 (6): 571–90. doi:10.2165/00003088-200544060-00002. PMID 15910008.

[AHFS2019-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ "Atomoxetine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 22 March 2019.

[BNF76-6] ୬.୦ ^୬.୧ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 344–345. ISBN 9780857113382.

[Preg2019-7] "Atomoxetine Pregnancy and Breastfeeding Warnings". Drugs.com (in ଇଂରାଜୀ). Retrieved 3 March 2019.

[NADAC2019-8] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[9] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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