ଭିଲାଣ୍ଟେରୋଲ

ଭିଲାଣ୍ଟେରୋଲ
Clinical data
Trade names	With fluticasone: Breo Ellipta, Relvar Ellipta; With umeclidinium: Anoro Ellipta; With both: Trelegy Ellipta
AHFS/Drugs.com	monograph
data	EU EMA: yes;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	By inhalation
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; ℞ (Prescription only);
Identifiers
	IUPAC name 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol;
ECHA InfoCard	100.217.751
Chemical and physical data
Formula	C24H33Cl2NO5
Molar mass	୪୮୬.୪୩ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl;
	InChI InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1; Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N;

ଭିଲାଣ୍ଟେରୋଲ ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତ କ୍ରନିକ ଅବଷ୍ଟ୍ରକ୍ଟିଭ ଫୁସଫୁସ ରୋଗ (COPD)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଆଜମା ରୋଗର ଅବନତିକୁ ରୋକିବା ପାଇଁ ଏହା ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୨] ଏହା ଅନ୍ୟ ଔଷଧ ସହିତ ମିଶି ପ୍ରଶ୍ୱାସରେ ନିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନାକ ଏବଂ ଗଳାର ଉତ୍ତେଜନା, ଛତ୍ରକ ରୋଗ ବା ଥ୍ରଶ୍ (thrush) ଏବଂ ଛାତି ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ ବ୍ରୋଙ୍କୋସ୍ପାଜ୍ମ ହୋଇପାରେ ।^[୧] ଏହା ଏକ ଦୀର୍ଘ କାଳୀନ କାର୍ଯ୍ୟକାରୀ β<sub>୨</sub> ଆଡ୍ରେନୋରିସେପ୍ଟର ଆଗୋନିଷ୍ଟ (LABA) ଅଟେ | ^[୧]

୨୦୧୩ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଫ୍ଲୁଟିକାସୋନ ସହିତ ଭିଲାଣ୍ଟେରୋଲ ଦେବାକୁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ଏହା ଉମେକ୍ଲିଡିନିଅମ/ଭିଲାଣ୍ଟେରୋଲ ଏବଂ ଫ୍ଲୁଟିକାସୋନ/ଉମେକ୍ଲିଡିନିଅମ/ ଭିଲାଣ୍ଟେରୋଲ୍ ନାମରେ ମଧ୍ୟ ଉପଲବ୍ଧ ।^[୧] ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏକ ମାସର ଔଷଧ ଖର୍ଚ୍ଚ ପ୍ରାୟ ୨୦ରୁ ୪୫ ପାଉଣ୍ଡ ହୋଇଥାଏ ।^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୧୯୦ ଡଲାର ଅଟେ ।^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Vilanterol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 January 2021. Retrieved 15 September 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 279. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". web.archive.org. 18 January 2017. Archived from the original on 18 January 2017. Retrieved 15 September 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
↑ "Breo Ellipta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 15 September 2021.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Vilanterol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 17 January 2021. Retrieved 15 September 2021.

[BNF80-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 279. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[3] "FDA approves Breo Ellipta to treat chronic obstructive pulmonary disease". web.archive.org. 18 January 2017. Archived from the original on 18 January 2017. Retrieved 15 September 2021.{{cite web}}: CS1 maint: bot: original URL status unknown (link)

[4] "Breo Ellipta Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 25 April 2020. Retrieved 15 September 2021.

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[୨]

[୩]

[୪]

Clinical data

Trade names	With fluticasone: Breo Ellipta, Relvar Ellipta With umeclidinium: Anoro Ellipta With both: Trelegy Ellipta
AHFS/Drugs.com	monograph
data	EU EMA: yes
Pregnancy category	AU: B3
Routes of administration	By inhalation
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only ℞ (Prescription only)
Identifiers
IUPAC name 4-{(1R)-2-[(6-{2-[(2,6-Dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol
ECHA InfoCard	100.217.751
Chemical and physical data
Formula	C₂₄H₃₃Cl₂NO₅
Molar mass	୪୮୬.୪୩ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c1cc(c(c(c1)Cl)COCCOCCCCCCNC[C@@H](c2ccc(c(c2)CO)O)O)Cl
InChI InChI=1S/C24H33Cl2NO5/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28/h5-9,14,24,27-30H,1-4,10-13,15-17H2/t24-/m0/s1 Key:DAFYYTQWSAWIGS-DEOSSOPVSA-N