ଡିଫେରେସିରକ୍ସ

ଡିଫେରେସିରକ୍ସ
Clinical data
Pronunciation	de FER a sir ox
Trade names	Exjade, Jadenu, others
Synonyms	CGP-72670, ICL-670A, IC L670
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Deferasirox;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	70%
Protein binding	99%
Metabolism	Liver glucuronidation
Elimination half-life	8 to 16 hours
Excretion	Fecal (84%) and renal (8%)
Identifiers
	IUPAC name 4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid;
ECHA InfoCard	100.211.077
Chemical and physical data
Formula	C21H15N3O4
Molar mass	୩୭୩.୩୭ g·mol−1
3D model (JSmol)	Interactive image;
Density	1.4±0.1 g/cm3
	SMILES OC(=O)c1ccc(cc1)n2nc(nc2c3ccccc3O)c4ccccc4O;
	InChI InChI=1S/C21H15N3O4/c25-17-7-3-1-5-15(17)19-22-20(16-6-2-4-8-18(16)26)24(23-19)14-11-9-13(10-12-14)21(27)28/h1-12,25-26H,(H,27,28) ; Key:BOFQWVMAQOTZIW-UHFFFAOYSA-N ;
(verify)

ଡିଫେରେସିରକ୍ସ, ଏକ୍ସଜେଡ୍ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ବିଟା-ଥାଲାସେମିଆ ଏବଂ ଅନ୍ୟାନ୍ୟ କ୍ରୋନିକ୍ ଆନିମିଆ ଯୋଗୁ ଭୋଗୁଥିବା ରକ୍ତହୀନତା ପାଇଁ ଦୀର୍ଘ ଦିନ ଧରି ରକ୍ତ ଗ୍ରହଣ କରୁଥିବା ବ୍ୟକ୍ତିଙ୍କର ଅତ୍ୟଧିକ ଲୌହ ଜମାହେଉଥିବା ଯୋଗୁ ଏହି ଔଷଧ ଦିଆଯାଏ । ^[୨] ସାଧାରଣତଃ ଯେତେବେଳେ ଡିଫେରକ୍ସାମାଇନ୍ ଯଥେଷ୍ଟ ନ ହେଲେ ଏହା ଦିଆଯାଏ ।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବୃକ୍‌କ ସମସ୍ୟା, ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ବୁକୁଜ୍ୱାଳା, ରାସ, ଗଲୁ ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମେଟାବୋଲିକ୍ ଏସିଡୋସିସ୍, ଅସ୍ଥି ମଜ୍ଜା ଦମନ ଏବଂ ପାକସ୍ଥଳୀ ରକ୍ତସ୍ରାବ ହୋଇପାରେ ।^[୨] ^[୪] ବୃକ୍‌କ ଜନିତ ସମସ୍ୟାରେ ଏହା ବ୍ୟବହାର କରାଯିବା ଉଚିତ୍ ନୁହେଁ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ଏହା କ୍ଷତିକାରକ ବୋଲି ବିଶ୍ୱାସ କରାଯାଏ ।^[୫] ଏହା ଏକ ଲୁହା ଚିଲେଟର ।^[୪]

୨୦୦୫ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ ୨୦୦୬ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଡିଫେରେସିରକ୍ସ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ^[୨] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଅଛି ।^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଦୈନିକ ୩୬୦ ମିଗ୍ରା ମାତ୍ରାରେ ମାସକୁ ପ୍ରାୟ ୫୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୧୯୦ ଡଲାର ଅଟେ ।^[୮] ଏହାର ଜେନେରିକ୍ ବା ଶ୍ରେଣୀଗତ ସଂସ୍କରଣଗୁଡିକ ୨୦୨୦ରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୯]

ଆଧାର

↑ "Material Safety Data Sheet (MSDS): Deferasirox". ChemSrc. 2018. Archived from the original on 2017-06-12. Retrieved 2021-06-28.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Exjade". Archived from the original on 16 September 2021. Retrieved 21 December 2021.
↑ ^୩.୦ ^୩.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1074. ISBN 978-0857114105.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "DailyMed - DEFERASIROX- deferasirox tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 21 December 2021.
↑ "Deferasirox Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 21 December 2021.
↑ "Deferasirox Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 15 August 2020. Retrieved 21 December 2021.
↑ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
↑ "Deferasirox Prices and Deferasirox Coupons - GoodRx". GoodRx. Retrieved 21 December 2021.
↑ "Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration. Archived from the original on 19 October 2020. Retrieved 15 August 2020.

[chemsrc-1] "Material Safety Data Sheet (MSDS): Deferasirox". ChemSrc. 2018. Archived from the original on 2017-06-12. Retrieved 2021-06-28.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Exjade". Archived from the original on 16 September 2021. Retrieved 21 December 2021.

[BNF81-3] ୩.୦ ^୩.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1074. ISBN 978-0857114105.

[PI2021-4] ୪.୦ ^୪.୧ ^୪.୨ "DailyMed - DEFERASIROX- deferasirox tablet, film coated". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 21 December 2021.

[5] "Deferasirox Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 November 2020. Retrieved 21 December 2021.

[AHFS2021-6] "Deferasirox Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 15 August 2020. Retrieved 21 December 2021.

[WHO23rd-7] World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.

[8] "Deferasirox Prices and Deferasirox Coupons - GoodRx". GoodRx. Retrieved 21 December 2021.

[9] "Drugs@FDA: FDA-Approved Drugs". U.S. Food and Drug Administration. Archived from the original on 19 October 2020. Retrieved 15 August 2020.

[୨]

[୩]

[୧]

[୪]

[୫]

[୬]

[୭]

[୮]

[୯]