ଡେଫେରୋକ୍ସାମିନ

ଡେଫେରୋକ୍ସାମିନ
	Skeletal formula and spacefill model of deferoxamine
Clinical data
Trade names	Desferal
Synonyms	desferrioxamine B, desferoxamine B, DFO-B, DFB,N'-[5-(Acetyl-hydroxy-amino)pentyl]-N-[5-[3-(5-aminopentyl-hydroxy-carbamoyl) propanoylamino]pentyl]-N-hydroxy-butane diamide
AHFS/Drugs.com	monograph
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	intramuscular; intravenous; subcutaneous;
ATC code	V03AC01 (WHO) ;
Pharmacokinetic data
Elimination half-life	6 hours
Identifiers
	IUPAC name N'-{5-[Acetyl(hydroxy)amino]pentyl}-N-[5-({4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoyl}amino)pentyl]-N-hydroxysuccinamide;
CAS Number	70-51-9;
PubChem CID	2973;
DrugBank	DB00746;
ChemSpider	2867;
UNII	J06Y7MXW4D;
KEGG	D03670;
ChEBI	CHEBI:4356;
ChEMBL	CHEMBL556;
ECHA InfoCard	100.000.671
Chemical and physical data
Formula	C25H48N6O8
Molar mass	୫୬୦.୬୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc(:[o]):n(:[oH])CCCCC[nH]:c(:[o])CCc(:[o]):n(:[oH])CCCCC[nH]:c(:[o])CCc(:[o]):n(:[oH])CCCCCN;
	InChI InChI=1S/C25H48N6O8/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34); ; Key:UBQYURCVBFRUQT-UHFFFAOYSA-N;

ଡେଫେରୋକ୍ସାମିନ (ଇଂରାଜୀ ଭାଷାରେ Deferoxamine ବା DFOA, ବିକ୍ରୟ ନାମ ଡେସଫେରାଲ/Desferal) ଏକ ଔଷଧ ଯାହା ଲୌହ (iron) ଓ ଆଲୁମିନିଅମ (aluminium) ସ‌ହିତ ସଂଯୁକ୍ତ ହୋଇଯାଏ ।^[୧] ଏହି ଅବସ୍ଥା ସାଧାରଣତଃ ଲୌହ ମାତ୍ରାଧିକ (iron overdose) ହେଲେ, ସଂଖ୍ୟାଧିକ ରକ୍ତ ସଞ୍ଚାରଣ (blood transfusion) ବା ଜେନେଟିକ (genetic condition) ଦୋଷରୁ ହେମୋକ୍ରୋମାଟୋସିସ (hemochromatosis) ହେଲେ ଓ ଡାଏଲିସିସରେ (dialysis) ଥିବା ଲୋକର ଆଲୁମିନିଅମ ବିଷମୟ (aluminium toxicity) ହେଲେ ଏହି ଔଷଧ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୧]^[୨] ଏହି ଔଷଧ ଇଞ୍ଜେକସନ ଆକାରରେ ମାଂସପେଶୀରେ (injection into a muscle) ବା ଶିରାଭ୍ୟନ୍ତରରେ (vein) ବା ଚର୍ମ ତଳେ (under the skin) ଦିଆଯାଏ ।^[୧]

ଡେଫେରୋକ୍ସାମିନର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଇଞ୍ଜେକସନ ଜାଗାରେ କଷ୍ଟ, ତରଳ ଝାଡ଼ା, ବାନ୍ତି, ଜ୍ୱର, ଶ୍ରବଣ ହାନୀ (hearing loss) ଓ ଚକ୍ଷୁ ସମସ୍ୟା ଇତ୍ୟାଦି ଲକ୍ଷଣ ଦେଖାଯାଏ । ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲାକ୍‌ସିସ ସ‌ହିତ ଆଲର୍ଜି (allergic reactions) ଓ ନିମ୍ନ ରକ୍ତଚାପ (low blood pressure) ହୋଇପାରେ । ^[୧] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ ସମୟରେ ଶିଶୁ ପ୍ରତି ଏହାର ନିରାପତ୍ତା ବିଷୟ ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୩] ଡେଫେରୋକ୍ସାମିନ ଏକ ସିଡେରୋଫୋର (siderophore) ଯାହା ସ୍ଟ୍ରେପ୍ଟୋମାଇସେସ ପାଇଲୋସସ୍ (Streptomyces pilosus) ଜୀବାଣୁରୁ ପ୍ରସ୍ତୁତ ହୋଇଥାଏ ।^[୪]

ଡେଫେରୋକ୍ସାମିନ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସନ ୧୯୬୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା । ^[୧] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ଦିନ ଡୋଜର କ୍ରୟ ମୂଲ୍ୟ ପ୍ରାୟ ୬.୭୬ରୁ ୧୩.୫୨ ଆମେରିକୀୟ ଡଲାର ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ କୋର୍ଷର ମୂଲ୍ୟ ପ୍ରାୟ ୨୦୦ ଡଲାରରୁ ଅଧିକ ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Deferoxamine Mesylate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 61-62. ISBN 978-92-4-154765-9. Retrieved 8 December 2016.
↑ "Deferoxamine (Desferal) Use During Pregnancy". www.drugs.com. Retrieved 13 December 2016.
↑ Hoffman, Ronald; Jr, Edward J. Benz; Silberstein, Leslie E.; Heslop, Helen; Weitz, Jeffrey; Anastasi, John (2012). Hematology: Diagnosis and Treatment (in ଇଂରାଜୀ) (6 ed.). Elsevier Health Sciences. p. 515. ISBN 1-4557-4041-1.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Deferoxamine". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 470. ISBN 978-1-284-05756-0.

[AHFS2016-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Deferoxamine Mesylate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[WHO2008-2] WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 61-62. ISBN 978-92-4-154765-9. Retrieved 8 December 2016.

[3] "Deferoxamine (Desferal) Use During Pregnancy". www.drugs.com. Retrieved 13 December 2016.

[4] Hoffman, Ronald; Jr, Edward J. Benz; Silberstein, Leslie E.; Heslop, Helen; Weitz, Jeffrey; Anastasi, John (2012). Hematology: Diagnosis and Treatment (in ଇଂରାଜୀ) (6 ed.). Elsevier Health Sciences. p. 515. ISBN 1-4557-4041-1.

[WHO19th-5] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-6] "Deferoxamine". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[Ric2015-7] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 470. ISBN 978-1-284-05756-0.

[୧]

[୨]

[୩]

[୪]

[୫]

[୬]

[୭]