ଟ୍ରାବେକ୍ଟେଡିନ

ଟ୍ରାବେକ୍ଟେଡିନ
Clinical data
Trade names	Yondelis
Synonyms	ecteinascidin 743, ET-743
AHFS/Drugs.com	monograph
MedlinePlus	a615059
data	EU EMA: yes; US DailyMed: Trabectedin;
Pregnancy; category	US: N (Not classified yet) ; ;
Routes of; administration	Intravenous
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	Not applicable (IV only)
Protein binding	94 to 98%
Metabolism	Liver (mostly CYP3A4-mediated)
Elimination half-life	180 hours (mean)
Excretion	Mostly fecal
Identifiers
	IUPAC name (1'R,6R,6aR,7R,13S,14S,16R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydrospiro[6,16-(epithiopropano-oxymethano)-7,13-imino-6aH-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-5-yl acetate;
ECHA InfoCard	100.223.368
Chemical and physical data
Formula	C39H43N3O11S
Molar mass	୭୬୧.୮୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1cc2c(c(c1OC)O)[C@@H]3[C@@H]4[C@H]5c6c(c7c(c(c6OC(=O)C)C)OCO7)[C@@H](N4[C@H]([C@H](C2)N3C)O)COC(=O)[C@@]8(CS5)c9cc(c(cc9CCN8)O)OC;
	InChI InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1 ; Key:PKVRCIRHQMSYJX-AIFWHQITSA-N ;
(verify)

ଟ୍ରାବେକ୍ଟେଡିନ, ୟୋଣ୍ଡେଲିସ ଏକ ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଆଗେଇଯାଇଥିବା କୋମଳ-ତନ୍ତୁ ସାର୍କୋମା ଏବଂ ଓଭାରି କର୍କଟ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଅନ୍ୟ କୌଣସି ଚିକିତ୍ସା ପ୍ରଭାବଶାଳୀ ନ ହେଲେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହା ଏକ ଶିରାରେ ଧୀରେ ଧୀରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୪] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାର ବିପଦକୁ ହ୍ରାସ କରିବା ପାଇଁ ଡେକ୍ସାମେଥାଜୋନ ବ୍ୟବହୃତ ହୁଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ରକ୍ତ ନିଉଟ୍ରୋଫିଲ୍ ସ୍ତର, ବାନ୍ତି, ଯକୃତ ସମସ୍ୟା, ସ୍ୱଳ୍ପ ଲାଲ ରକ୍ତ କଣିକା ସ୍ତର, ଥକାପଣ, କମ ପ୍ଲାଟେଲେଟ ସ୍ତର ଏବଂ ତରଳ ଝାଡ଼ା ହୋଇପାରେ ।^[୪] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରାବଡୋମାୟୋଲାଇସିସ, ହୃଦ୍‌ପାତ ଏବଂ ପ୍ରଜନନ କ୍ଷମତା ହ୍ରାସ ହୋଇପାରେ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୫] ଔଷଧ ଯୋଗୁଁ ୨% ଲୋକଙ୍କର ମୃତ୍ୟୁ ଘଟିଥାଏ ।^[୪] ଏହା ଏକ ଆଲକିଲେଟିଂ ଏଜେଣ୍ଟ।^[୫]

୨୦୦୭ ମସିହାରେ ୟୁରୋପରେ ଏବଂ ୨୦୧୫ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଟ୍ରାବେକ୍ଟେଡିନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୫] ଏହା ପ୍ରଥମେ ୨୦୦୧ରେ ୟୁରୋପରେ ଏକ ଅନାଥ ଔଷଧ (orphan medicine) ଭାବରେ ନାମିତ ହୋଇଥିଲା ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ଏହାର ୧ ମିଗ୍ରାର ମୂଲ୍ୟ ୧୪୦୦ ପାଉଣ୍ଡ ଥିଲା ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୩୨୫୦ ଡଲାର ଅଟେ ।^[୭] ଏହା ମୂଳତଃ ଏକ ସମୁଦ୍ର ସ୍କ୍ୱିର୍ଟରୁ (sea squirt) ଉତ୍ପନ୍ନ ହୋଇଥିଲା ।^[୪]

ଆଧାର

↑ "Yondelis EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 30 September 2020.
↑ "Yondelis 1 mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 21 September 2020. Archived from the original on 29 August 2021. Retrieved 30 September 2020.
↑ "Yondelis- trabectedin injection, powder, lyophilized, for solution". DailyMed. 22 September 2020. Archived from the original on 25 October 2020. Retrieved 30 September 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ ^୪.୬ ^୪.୭ "Yondelis". Archived from the original on 22 October 2020. Retrieved 8 October 2021.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Trabectedin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 October 2021.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 972. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Yondelis Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 8 October 2021.

[Yondelis_EPAR-1] "Yondelis EPAR". European Medicines Agency (EMA). Archived from the original on 22 October 2020. Retrieved 30 September 2020.

[2] "Yondelis 1 mg powder for concentrate for solution for infusion - Summary of Product Characteristics (SmPC)". (emc). 21 September 2020. Archived from the original on 29 August 2021. Retrieved 30 September 2020.

[Yondelis_FDA_label-3] "Yondelis- trabectedin injection, powder, lyophilized, for solution". DailyMed. 22 September 2020. Archived from the original on 25 October 2020. Retrieved 30 September 2020.

[EPAR2021-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ ^୪.୬ ^୪.୭ "Yondelis". Archived from the original on 22 October 2020. Retrieved 8 October 2021.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ "Trabectedin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 8 October 2021.

[BNF80-6] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 972. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[7] "Yondelis Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 January 2021. Retrieved 8 October 2021.

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