ଏପ୍ଲେରେନୋନ

ଏପ୍ଲେରେନୋନ
Clinical data
Pronunciation	/ɛpˈlɛrənoʊn/
Trade names	Inspra, Epnone, Dosterep, others
Synonyms	SC-66110; CGP-30083; 9-11α-Epoxymexrenone; 9,11α-Epoxy-7α-methoxycarbonyl-3-oxo-17α-pregn-4-ene-21,17-carbolactone
AHFS/Drugs.com	monograph
MedlinePlus	a603004
Pregnancy; category	AU: B3 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth (tablets)
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	~70%
Protein binding	~50% (33–60%) (primarily to α1-acid glycoprotein)
Metabolism	Liver (CYP3A4)
Metabolites	6β-OH-EPL, 6β,21-OH-EPL, 21-OH-EPL, 3α,6β-OH-EPL (All inactive)
Onset of action	Within 2 weeks
Elimination half-life	4–6 hours
Excretion	Urine (67%), feces (32%)
Identifiers
	IUPAC name methyl (4aS,4bR,5aR,6aS,7R,9aS,9bR,10R)-4a,6a-dimethyl-2,5'-dioxo-2,4,4',4a,5',5a,6,6a,8,9,9a,9b,10,11-tetradecahydro-3H,3'H-spiro[cyclopenta[7,8]phenanthro[4b,5-b]oxirene-7,2'-furan]-10-carboxylate;
ECHA InfoCard	100.106.615
Chemical and physical data
Formula	C24H30O6
Molar mass	୪୧୪.୫0 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)[C@@H]4C\C1=C\C(=O)CC[C@]1(C)[C@@]65O[C@@H]6C[C@@]3(C)[C@@H](CC[C@]23CCC(=O)O2)[C@H]45;
	InChI InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1 ; Key:JUKPWJGBANNWMW-VWBFHTRKSA-N ;
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ଏପ୍ଲେରେନୋନ, ଏକ ବେପାର ନାମ ଇନ୍ସପ୍ରା, ହେଉଛି ଏକ ଔଷଧ ଯାହା ହୃଦ୍‌ପାତ ଏବଂ ଉଚ୍ଚ ରକ୍ତଚାପର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଉଚ୍ଚ ରକ୍ତଚାପ ପାଇଁ ଏହା ଦ୍ୱିତୀୟ ଧାଡି ଚିକିତ୍ସା | ^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩] ଏହାର ପ୍ରଭାବ ସାଧାରଣତ ୨ ସପ୍ତାହ ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଉଚ୍ଚ ରକ୍ତ ପୋଟାସିୟମ୍ ସ୍ତର, ତରଳ ଝାଡ଼ା, ସ୍ତନ ବୃଦ୍ଧି ଏବଂ ପେଟ ଯନ୍ତ୍ରଣା ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅନିୟମିତ ହୃତ୍ ସ୍ପନ୍ଦନ, ଆଞ୍ଜିଓଇଡିମା ଏବଂ ଛିଡା ହେବା ସହିତ ନିମ୍ନ ରକ୍ତଚାପ ହୋଇପାରେ ।^[୬] ଏହା ଏକ ଆଲଡୋଷ୍ଟେରନ୍ ଆଣ୍ଟାଗୋନିଷ୍ଟ ଏବଂ ଏକ ପୋଟାସିୟମ୍-ସ୍ପେଆରିଙ୍ଗ୍ ଡାଇୟୁରେଟିକ୍ ।^[୬]

୨୦୦୨ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଏପ୍ଲେରେନୋନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୨୫ପାଉଣ୍ଡ ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୁଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୧୯ ଡଲାର ଥିଲା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Lemke TL, Williams DA (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 743–. ISBN 978-1-60913-345-0. Archived from the original on 1 August 2020. Retrieved 6 July 2021.
↑ ^୨.୦ ^୨.୧ Sica DA (January 2005). "Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis". Heart Failure Reviews. 10 (1): 23–9. doi:10.1007/s10741-005-2345-1. PMID 15947888. S2CID 21437788.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Eplerenone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 August 2020. Retrieved 23 July 2021.
↑ Struthers A, Krum H, Williams GH (April 2008). "A comparison of the aldosterone-blocking agents eplerenone and spironolactone". Clinical Cardiology. 31 (4): 153–8. doi:10.1002/clc.20324. PMC 6652937. PMID 18404673.
↑ Frishman WH, Cheng-Lai A, Nawarskas J (4 January 2005). Current Cardiovascular Drugs. Springer Science & Business Media. pp. 246–. ISBN 978-1-57340-221-7. Archived from the original on 1 August 2020. Retrieved 6 July 2021.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 206. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Eplerenone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 17 January 2021. Retrieved 23 July 2021.

[LemkeWilliams2012-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Lemke TL, Williams DA (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 743–. ISBN 978-1-60913-345-0. Archived from the original on 1 August 2020. Retrieved 6 July 2021.

[Sica2005-2] ୨.୦ ^୨.୧ Sica DA (January 2005). "Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis". Heart Failure Reviews. 10 (1): 23–9. doi:10.1007/s10741-005-2345-1. PMID 15947888. S2CID 21437788.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Eplerenone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 19 August 2020. Retrieved 23 July 2021.

[StruthersKrum2008-4] Struthers A, Krum H, Williams GH (April 2008). "A comparison of the aldosterone-blocking agents eplerenone and spironolactone". Clinical Cardiology. 31 (4): 153–8. doi:10.1002/clc.20324. PMC 6652937. PMID 18404673.

[FrishmanCheng-Lai2005-5] Frishman WH, Cheng-Lai A, Nawarskas J (4 January 2005). Current Cardiovascular Drugs. Springer Science & Business Media. pp. 246–. ISBN 978-1-57340-221-7. Archived from the original on 1 August 2020. Retrieved 6 July 2021.

[BNF80-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 206. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[GX2021-7] "Eplerenone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 17 January 2021. Retrieved 23 July 2021.

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