ଅକ୍ସାଣ୍ଡ୍ରୋଲୋନ

ଅକ୍ସାଣ୍ଡ୍ରୋଲୋନ
Clinical data
Trade names	Oxandrin, Anavar, others
Synonyms	Var; CB-8075; NSC-67068; SC-11585; Protivar; 17α-Methyl-2-oxa-4,5α-dihydrotestosterone; 17α-Methyl-2-oxa-DHT; 17α-Methyl-2-oxa-5α-androstan-17β-ol-3-one
AHFS/Drugs.com	monograph
MedlinePlus	a604024
Pregnancy; category	X;
Routes of; administration	By mouth
Drug class	Androgen; Anabolic steroid
ATC code	A14AA08 (WHO) ;
Legal status
Legal status	CA: Schedule IV ; US: Schedule III ;
Pharmacokinetic data
Bioavailability	97%
Protein binding	94–97%
Metabolism	Kidneys (primarily), liver
Elimination half-life	Adults: 9.4–10.4 hours; Elderly: 13.3 hours
Excretion	Urine: 28% (unchanged); Feces: 3%
Identifiers
	IUPAC name (1S,3aS,3bR,5aS,9aS,9bS,11aS)-1-hydroxy-1,9a,11a-trimethyl-2,3,3a,3b,4,5,5a,6,9,9b,10,11-dodecahydroindeno[4,5-h]isochromen-7-one;
CAS Number	53-39-4 ;
PubChem CID	5878;
IUPHAR/BPS	7092;
DrugBank	DB00621 ;
ChemSpider	5667 ;
UNII	7H6TM3CT4L;
KEGG	D00462 ;
ChEBI	CHEBI:7820 ;
ChEMBL	CHEMBL1200436 ;
ECHA InfoCard	100.000.158
Chemical and physical data
Formula	C19H30O3
Molar mass	୩୦୬.୪୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C)O)CC[C@@H]4[C@@]3(COC(=O)C4)C;
	InChI InChI=1S/C19H30O3/c1-17-11-22-16(20)10-12(17)4-5-13-14(17)6-8-18(2)15(13)7-9-19(18,3)21/h12-15,21H,4-11H2,1-3H3/t12-,13+,14-,15-,17-,18-,19-/m0/s1 ; Key:QSLJIVKCVHQPLV-PEMPUTJUSA-N ;
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ଅକ୍ସାଣ୍ଡ୍ରୋଲୋନ, ଏକ ବ୍ୟବସାୟୀକ ନାମ ଅକ୍ସାଣ୍ଡ୍ରିନ, ଏକ ଉତ୍ପାଦିତ ଆଣ୍ଡ୍ରୋଜେନ ଓ ଆନାବୋଲିକ ଷ୍ଟିରଏଡ (AAS) | ^[୪] ଏହା ଓଜନ କମୁଥିବା ଲୋକଙ୍କର ଓଜନ ବୃଦ୍ଧି କରିବାକୁ, ଦୀର୍ଘକାଳୀନ କର୍ଟିକୋଷ୍ଟିରଏଡ ସେବନ ଜନିତ ପ୍ରୋଟିନ କ୍ଷୟକୁ ଅବରୋଧ କରିବାକୁ ଓ ଓଷ୍ଟିଓପୋରୋସିସ୍ ଯୋଗୁ ହେଉଥିବା ହାଡ଼ ଯନ୍ତ୍ରଣାକୁ ରୋକିବା ପାଇଁ ଏହା ବ୍ୟବହୃତ ହୁଏ | ^[୫] ^[୬] ଏହା ପାଟିରେ ଦିଆଯାଏ । ^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା ଏବଂ ଅସ୍ୱାଭାବିକ ଲିପିଡ ହେବା ଦେଖାଯାଏ | ^[୪] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦ୍‌ପାତ, ବ୍ରଣ, କେଶ ବୃଦ୍ଧି ଏବଂ ସ୍ୱର ପରିବର୍ତ୍ତନ ହୋଇପାରେ | ^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୫] ଟେଷ୍ଟୋଷ୍ଟେରନର ଜୈବିକ ଲକ୍ଷ ଥିବା ଆଣ୍ଡ୍ରୋଜେନ ରିସେପ୍ଟରକୁ (ଏଆର) ଅକ୍ସାଣ୍ଡ୍ରୋଲୋନ ସକ୍ରିୟ କରିଥାଏ | ^[୭] ଆଣ୍ଡ୍ରୋଜେନିକ ପ୍ରଭାବ ଅପେକ୍ଷା ଏହାର ଅଧିକ ଆନାବୋଲିକ ପ୍ରଭବ ଥାଏ । ^[୫]

୧୦୬୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅକ୍ସାଣ୍ଡ୍ରୋଲୋନ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୪] ଏହା ଯୁକ୍ତରାଜ୍ୟରେ ମେଡିକାଲରେ ଉପଲବ୍ଧ ନୁହେଁ। ^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦୦ ମିଗ୍ରାର ୬୦ଟି ଟାବଲେଟର ମୂଲ୍ୟ ପ୍ରାୟ ୨୮୪ ଡଲାର ଅଟେ। ^[୮] କ୍ରିଡ଼ା କ୍ଷେତ୍ରରେ ସ୍ୱାସ୍ଥ୍ୟ ଓ ପ୍ରଦର୍ଶନର ଉନ୍ନତ କରିବା ପାଇଁ ଏହା ମଧ୍ୟ ଅନୁପଯୁକ୍ତ ଭାବରେ ବ୍ୟବହୃତ ହୋଇଛି | ^[୫] ଏହା ଅନେକ ଦେଶରେ ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ, ତେଣୁ ଅଣ-ଚିକିତ୍ସା ସାଧାରଣତଃ ବେଆଇନ୍ ଅଟେ | ^[୯] ^[୧୦] ^[୧୧]

ଆଧାର

↑ R.A.S Hemat (2 March 2003). Andropathy. Urotext. pp. 108–. ISBN 978-1-903737-08-8.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ Ashraf Mozayani; Lionel Raymon (15 October 2003). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer Science & Business Media. pp. 513–. ISBN 978-1-59259-654-6.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ Miller JT, Btaiche IF (February 2009). "Oxandrolone treatment in adults with severe thermal injury" (PDF). Pharmacotherapy. 29 (2): 213–26. doi:10.1592/phco.29.2.213. hdl:2027.42/90285. PMID 19170590. S2CID 25780591.
↑ ^୪.୦ ^୪.୧ ^୪.୨ "Oxandrolone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 December 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ "Oxandrolone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 December 2020.
↑ Li H, Guo Y, Yang Z, Roy M, Guo Q (June 2016). "The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis". Burns. 42 (4): 717–27. doi:10.1016/j.burns.2015.08.023. PMID 26454425.
↑ ^୭.୦ ^୭.୧ Kicman AT (June 2008). "Pharmacology of anabolic steroids". British Journal of Pharmacology. 154 (3): 502–21. doi:10.1038/bjp.2008.165. PMC 2439524. PMID 18500378.
↑ "Oxandrolone Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Retrieved 14 December 2020.
↑ "Controlled Substances Act". United States Food and Drug Administration. 11 June 2009. Retrieved 17 June 2016.
↑ Branch, Legislative Services. "Consolidated federal laws of Canada, Controlled Drugs and Substances Act". laws-lois.justice.gc.ca. Retrieved 2017-01-14.
↑ "List of most commonly encountered drugs currently controlled under the misuse of drugs legislation - GOV.UK". www.gov.uk. Retrieved 2017-01-14.

[Hemat2003-1] R.A.S Hemat (2 March 2003). Andropathy. Urotext. pp. 108–. ISBN 978-1-903737-08-8.

[MozayaniRaymon2003-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ Ashraf Mozayani; Lionel Raymon (15 October 2003). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer Science & Business Media. pp. 513–. ISBN 978-1-59259-654-6.

[pmid19170590-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ Miller JT, Btaiche IF (February 2009). "Oxandrolone treatment in adults with severe thermal injury" (PDF). Pharmacotherapy. 29 (2): 213–26. doi:10.1592/phco.29.2.213. hdl:2027.42/90285. PMID 19170590. S2CID 25780591.

[AHFS2020-4] ୪.୦ ^୪.୧ ^୪.୨ "Oxandrolone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 December 2020.

[autogen3-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ "Oxandrolone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Retrieved 14 December 2020.

[LiGuo2016-6] Li H, Guo Y, Yang Z, Roy M, Guo Q (June 2016). "The efficacy and safety of oxandrolone treatment for patients with severe burns: A systematic review and meta-analysis". Burns. 42 (4): 717–27. doi:10.1016/j.burns.2015.08.023. PMID 26454425.

[BMJ2008-7] ୭.୦ ^୭.୧ Kicman AT (June 2008). "Pharmacology of anabolic steroids". British Journal of Pharmacology. 154 (3): 502–21. doi:10.1038/bjp.2008.165. PMC 2439524. PMID 18500378.

[GX2020-8] "Oxandrolone Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Retrieved 14 December 2020.

[FDA2009-9] "Controlled Substances Act". United States Food and Drug Administration. 11 June 2009. Retrieved 17 June 2016.

[CanadaLaws-10] Branch, Legislative Services. "Consolidated federal laws of Canada, Controlled Drugs and Substances Act". laws-lois.justice.gc.ca. Retrieved 2017-01-14.

[GovUK-11] "List of most commonly encountered drugs currently controlled under the misuse of drugs legislation - GOV.UK". www.gov.uk. Retrieved 2017-01-14.

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