ଟାଇମୋଲୋଲ

ଟାଇମୋଲୋଲ
Clinical data
Trade names	Betimol, others
AHFS/Drugs.com	monograph
MedlinePlus	a602022
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, topical (eye drop)
ATC code	C07AA06 (WHO) S01ED01;
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	60%
Metabolism	Liver (80%)
Elimination half-life	2.5–5 hours
Excretion	Kidney
Identifiers
	IUPAC name (S)-1-(tert-Butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol;
CAS Number	26839-75-8 ;
PubChem CID	33624;
IUPHAR/BPS	565;
DrugBank	DB00373 ;
ChemSpider	31013 ;
UNII	5JKY92S7BR;
KEGG	D08600 ;
ChEBI	CHEBI:9599 ;
ChEMBL	CHEMBL499 ;
ECHA InfoCard	100.043.651
Chemical and physical data
Formula	C13H24N4O3S
Molar mass	316.421 g/mol
3D model (JSmol)	Interactive image;
	SMILES O[C@H](COc1nsnc1N2CCOCC2)CNC(C)(C)C;
	InChI InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1 ; Key:BLJRIMJGRPQVNF-JTQLQIEISA-N ;
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ଟାଇମୋଲୋଲ (ଇଂରାଜୀ ଭାଷାରେ Timolol) ଏକ ଔଷଧ ଯାହା ପାଟିରେ ଦିଆଯାଏ ବା ଆଖି ଡ୍ରପ (eye drops) ଭାବରେ ଦିଆଯାଏ ।^[୨]^[୩] ଆଖି ଭିତର ଚାପ (pressure inside the eye) ବଢ଼ୁଥିବା ରୋଗ ଯେପରିକି ଓକୁଲାର ହାଇପରଟେନସନ (ocular hypertension) ଓ ଗ୍ଲକୋମା ଭଳି ରୋଗମାନଙ୍କରେ ଦିଆଯାଏ ।^[୨] ଉଚ୍ଚ ରକ୍ତଚାପ ଓ ଆଞ୍ଜାଇନା (chest pain due to insufficient blood flow to the heart) ରୋଗ ଚିକିତ୍ସାରେ, ହୃଦ୍‌ଘାତର ଜଟିଳତା ଓ ଅଧକପାଳିର ପ୍ରତିରୋଧ ନିମନ୍ତେ ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ଟାଇମୋଲୋଲ ଡ୍ରପର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଖିରେ ଜଳାପୋଡ଼ା ହୋଇପାରେ ।^[୨] ପାଟିରେ ଦିଆଯାଇଥିବା ଔଷଧ ଯୋଗୁ ଥକ୍କା ଅନୁଭବ, ଧୀର ହୃଦ୍ ଗତି (slow heart beat), ଗଲୁ ଓ ଅଣନିଶ୍ୱାସୀ (shortness of breath) ଆଦି ହୋଇପାରେ ।^[୩] ମଧୁମେହ ରୋଗରେ କମ୍ ରକ୍ତ ଶର୍କରାର ଲକ୍ଷଣ ଘୋଡ଼େଇ ଦିଏ । ଆଜ୍‌ମା, ହୃଦ୍‌ଘାତ ଓ ସିଓପିଡି ରୋଗ ଥିବା ଲୋକଙ୍କୁ ଏହି ଔଷଧ ଦେବାକୁ ସୁପାରିସ କରାଯାଏନାହିଁ ।^[୨] ଗର୍ଭସ୍ଥ ଶିଶୁ ପ୍ରତି ଏହାର ନିରାପତ୍ତା ବିଷୟ ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୪] ଏହା ବିଟା ବ୍ଲକର (non-selective Beta blocker) ଶ୍ରେଣୀର ଏକ ଔଷଧ । ^[୨]

ସନ ୧୯୬୮ରେ ଟାଇମୋଲୋଲ ପେଟେଣ୍ଟ ହେବାପରେ ସନ ୧୯୭୮ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାରରେ ଲାଗିଲା ।^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୬] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୨] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ୫ମି:ଲି: ବୋତଲର ହୋଲସେଲ କ୍ରୟ ମୂଲ୍ୟ ପ୍ରାୟ ୦.୮୬ରୁ ୨.୨୯ ଆମେରିକୀୟ ଡଲାର ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସର ଖର୍ଚ୍ଚ ୨୫ରୁ ୫୦ ଆମେରିକୀୟ ଡଲାର ।^[୮]

ଆଧାର

↑ "Timolol - Drugs.com". www.drugs.com. Retrieved 28 December 2016.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Timolol eent". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "Timolol Maleate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ "Timolol ophthalmic Use During Pregnancy | Drugs.com". www.drugs.com. Retrieved 28 December 2016.
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 460. ISBN 9783527607495.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Timolol Maleate". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 411. ISBN 9781284057560.

[genericnames-1] "Timolol - Drugs.com". www.drugs.com. Retrieved 28 December 2016.

[AHFS2016Eye-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Timolol eent". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[AHFS2016PO-3] ୩.୦ ^୩.୧ ^୩.୨ "Timolol Maleate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[4] "Timolol ophthalmic Use During Pregnancy | Drugs.com". www.drugs.com. Retrieved 28 December 2016.

[Fis2006-5] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 460. ISBN 9783527607495.

[WHO19th-6] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-7] "Timolol Maleate". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[Ric2015-8] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 411. ISBN 9781284057560.

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Clinical data


Trade names	Betimol, others^[୧]
AHFS/Drugs.com	monograph
MedlinePlus	a602022
Pregnancy category	AU: C US: C (Risk not ruled out)
Routes of administration	By mouth, topical (eye drop)
ATC code	C07AA06 (WHO) S01ED01
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Bioavailability	60%
Metabolism	Liver (80%)
Elimination half-life	2.5–5 hours
Excretion	Kidney
Identifiers
IUPAC name (S)-1-(tert-Butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol
CAS Number	26839-75-8^Y
PubChem CID	33624
IUPHAR/BPS	565
DrugBank	DB00373^Y
ChemSpider	31013^Y
UNII	5JKY92S7BR
KEGG	D08600^Y
ChEBI	CHEBI:9599^Y
ChEMBL	CHEMBL499^Y
ECHA InfoCard	100.043.651
Chemical and physical data
Formula	C₁₃H₂₄N₄O₃S
Molar mass	316.421 g/mol
3D model (JSmol)	Interactive image
SMILES O[C@H](COc1nsnc1N2CCOCC2)CNC(C)(C)C
InChI InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1^Y Key:BLJRIMJGRPQVNF-JTQLQIEISA-N^Y
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