ଟରବିନାଫାଇନ

ଟରବିନାଫାଇନ
Clinical data
Trade names	Lamisil, Terboderm, others
AHFS/Drugs.com	monograph
MedlinePlus	a699061
Pregnancy; category	B[କେଉଁଠାରେ?];
Routes of; administration	by mouth and topical
ATC code	D01AE15 (WHO) D01BA02;
Legal status
Legal status	Low-strength topical preparations available without prescription;
Pharmacokinetic data
Bioavailability	Readily absorbed: 70–90%
Protein binding	>99%
Metabolism	liver
Elimination half-life	Highly variable
Identifiers
	IUPAC name [(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)(naphthalen-1-ylmethyl)amine;
CAS Number	91161-71-6 ;
PubChem CID	1549008;
DrugBank	DB00857 ;
ChemSpider	1266005 ;
UNII	G7RIW8S0XP;
KEGG	D02375 ;
ChEBI	CHEBI:9448 ;
ChEMBL	CHEMBL822 ;
ECHA InfoCard	100.119.605
Chemical and physical data
Formula	C21H25N
Molar mass	291.43 g/mol
3D model (JSmol)	Interactive image;
	SMILES C(#C\C=C\CN(C)Cc2cccc1ccccc12)C(C)(C)C;
	InChI InChI=1S/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+ ; Key:DOMXUEMWDBAQBQ-WEVVVXLNSA-N ;
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ଟରବିନାଫାଇନ (ଇଂରାଜୀ ଭାଷାରେ Terbinafine, ବିକ୍ରୟ ନାମ ଲାମିସିଲ।/Lamisil) ଏକ କବକରୋଧୀ ବା ଆଣ୍ଟିଫଙ୍ଗାଲ ଔଷଧ (antifungal medication) ଯାହା ଯାଦୁ (ringworm), ପିଟିରିଆସିସ ଭର୍ସିକଲର (pityriasis versicolor) ଓ ଓନିକୋମାଇକୋସିସ (ନଖର କବକ ସଂକ୍ରମଣ) ରୋଗମାନଙ୍କରେ ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୧]^[୨] ଏହି ଔଷଧ ପାଟିରେ ଦିଆଯାଏ, ଚର୍ମରେ କ୍ରିମ ବା ମଲମ ଆକାରରେ ଲଗାଯାଏ । ^[୧]^[୩] ନଖର ସଂକ୍ରମଣରେ କ୍ରିମ ଓ ମଲମ କାମ କରେନାହିଁ ।^[୪]

ଟରବିନାଫାଇନ ପାଟିରେ ଦେଲେ ଅଇ, ତରଳ ଝାଡ଼ା, ମୁଣ୍ଡବଥା, କାଶ, ରାସ ଓ ଯକୃତ ଏଞ୍ଜାଇମ ବୃଦ୍ଧି ([[::en:elevated liver enzymes|:en:elevated liver enzymes]]) ହେବା ଭଳି ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାମାନ ଦେଖାଯାଏ ।^[୧] ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା (liver problems) ଓ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟାମାନ (allergic reactions) ଦେଖାଯାଏ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ଏହା ଦେବାକୁ ସୁପାରିସ କରାଯାଏନାହିଁ ।^[୧] କ୍ରିମ ଓ ମଲମ ଲଗେଇଲେ ଗଲୁ ହୋଇପାରେ । ^[୨] ଟରବିନାଫାଇନ ଏକ ଆଲିଲାମାଇନ (allylamines) ଶ୍ରେଣୀର ଔଷଧ ।^[୧] କବକର ସ୍ଟିରଲ (sterols) ତିଆରି କରିବା ଶକ୍ତିକୁ ଏହି ଔଷଧ କମେଇ ଦେଇ କାର୍ଯ୍ୟକାରୀ ହୁଏ । ^[୧]

ସନ ୧୯୯୧ରେ ଟରବିନାଫାଇନ ଆବିଷ୍କୃତ ହୋଇଥିଲା ।^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୬] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ୨୦ ଗ୍ରାମ ଟ୍ୟୁବର କ୍ରୟ ମୂଲ୍ୟ ୨.୨୦ ଆମେରିକୀୟ ଡଲାର ।^[୭] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ କୋର୍ଷ ଚିକିତ୍ସାର ଔଷଧ ମୂଲ୍ୟ ୨୫ ଆମେରିକୀୟ ଡଲାରରୁ କମ୍ ଏହା ବିନା ପ୍ରେସକ୍ରିପସନ୍‌ରେ (over the counter) ମିଳେ ।^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Terbinafine Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ ^୨.୦ ^୨.୧ "Lamisil 1% w/w Cream - Summary of Product Characteristics (SPC) - (eMC)". electronic Medicines Compendium (eMC). 17 March 2016. Retrieved 17 December 2016.
↑ "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved 10 May 2015.
↑ ^୪.୦ ^୪.୧ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 180. ISBN 978-1-284-05756-0. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ Ravina, Enrique (2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 90. ISBN 978-3-527-32669-3. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Terbinafine". International Drug Price Indicator Guide. Archived from the original on 6 April 2017. Retrieved 8 December 2016.

[AHFS2016-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Terbinafine Hydrochloride". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[UK2016-2] ୨.୦ ^୨.୧ "Lamisil 1% w/w Cream - Summary of Product Characteristics (SPC) - (eMC)". electronic Medicines Compendium (eMC). 17 March 2016. Retrieved 17 December 2016.

[WHO2015E-3] "19th WHO Model List of Essential Medicines (April 2015)" (PDF). WHO. April 2015. Retrieved 10 May 2015.

[Ric2015-4] ୪.୦ ^୪.୧ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 180. ISBN 978-1-284-05756-0. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[5] Ravina, Enrique (2011). The Evolution of Drug Discovery: From Traditional Medicines to Modern Drugs. John Wiley & Sons. p. 90. ISBN 978-3-527-32669-3. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[WHO19th-6] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-7] "Terbinafine". International Drug Price Indicator Guide. Archived from the original on 6 April 2017. Retrieved 8 December 2016.

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