ମେମାଣ୍ଟିନ

ମେମାଣ୍ଟିନ
Clinical data
Trade names	Axura, Ebixa, Namenda, others
AHFS/Drugs.com	monograph
MedlinePlus	a604006
data	EU EMA: yes; US FDA: Namenda;
Pregnancy; category	AU: B2 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	By mouth
ATC code	N06DX01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	~100%
Metabolism	Liver (<10%)
Elimination half-life	60–100 hours
Excretion	Kidney
Identifiers
	IUPAC name 3,5-dimethyltricyclo[3.3.1.13,7]decan-1amine; or; 3,5-dimethyladamantan-1-amine;
CAS Number	19982-08-2 ;
PubChem CID	4054;
IUPHAR/BPS	4253;
DrugBank	DB01043 ;
ChemSpider	3914 ;
UNII	W8O17SJF3T;
KEGG	D08174 ;
ChEMBL	CHEMBL807 ;
Chemical and physical data
Formula	C12H21N
Molar mass	179.3 g/mol
3D model (JSmol)	Interactive image;
	SMILES NC12CC3(CC(C1)(CC(C2)C3)C)C;
	InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3 ; Key:BUGYDGFZZOZRHP-UHFFFAOYSA-N ;
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ମେମାଣ୍ଟିନ (ଇଂରାଜୀ ଭାଷାରେ Memantine) ଏକ ଔଷଧ ଯାହା ମଧ୍ୟମରୁ ସାଂଘାତିକ ଧରଣର ଆଲଜିମର ରୋଗ ରୋଗର ଚିକିତ୍ସାରେ ଦିଆଯାଏ ।^[୨]^[୩] ଡୋନେପେଜିଲ ଭଳି ଆସେଟାଇଲକୋଲିନ ଇନହିବିଟର (acetylcholinesterase inhibitors) ଅପେକ୍ଷା ମେମାଣ୍ଟିନ କମ୍ ପସନ୍ଦ କରାଯାଏ । ^[୩] କିଛି ଉପଶମ ହେବା ଲକ୍ଷ କରାଗଲେ ଏହି ଔଷଧ ଚାଲୁ ରଖାଯାଏ ।^[୩] ପାଟିରେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୨]

ମେମାଣ୍ଟିନର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବିନ୍ଧା, କୋଷ୍ଠକାଠିନ୍ୟ, ନିଦ୍ରାଳୁ ଭାବ ଓ ମୁଣ୍ଡ ଓଜନିଆ ଲାଗେ । ^[୨]^[୩] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ରକ୍ତ ଜମାଟ, ସାଇକୋସିସ ^[୩] ଏହା ଏନଏମଡିଏ ରିସେପ୍ଟରକୁ (NMDA receptors) ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୨]

ସନ ୨୦୦୩ରେ ମେମାଣ୍ଟିନ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୨] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୩] ସନ ୨୦୧୯ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ଏହାର ଏକ ମାସର ଡୋଜ ପିଛା ପ୍ରାୟ ୧.୬୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା ।^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୫.୫୦ ଆମେରିକୀୟ ଡଲାର । ^[୪] ସନ ୨୦୧୬ରେ ଏହାର ୪ ନିୟୁତରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିସନ ତାଲିକାର ୧୪୭ତମ ସ୍ଥାନରେ ଥଲା ।^[୫]

ଆଧାର

↑ "International brands for memantine". Drugs.com. Retrieved 7 August 2017.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Memantine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 303–304. ISBN 9780857113382.
↑ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ଅଧିକ ପଢ଼ନ୍ତୁ

Lipton SA (2005). "The molecular basis of memantine action in Alzheimer's disease and other neurologic disorders: low-affinity, uncompetitive antagonism". Current Alzheimer Research. 2 (2): 155–65. doi:10.2174/1567205053585846. PMID 15974913.

ବାହ୍ୟ ଲିଙ୍କ

Drug Information from the NIH

[brands-1] "International brands for memantine". Drugs.com. Retrieved 7 August 2017.

[AHFS2019-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Memantine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 3 March 2019.

[BNF76-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 303–304. ISBN 9780857113382.

[NADAC2019-4] "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-06. Retrieved 3 March 2019.

[5] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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[୧]

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Clinical data


Trade names	Axura, Ebixa, Namenda, others^[୧]
AHFS/Drugs.com	monograph
MedlinePlus	a604006
data	EU EMA: yes US FDA: Namenda
Pregnancy category	AU: B2 US: B (No risk in non-human studies)
Routes of administration	By mouth
ATC code	N06DX01 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	~100%
Metabolism	Liver (<10%)
Elimination half-life	60–100 hours
Excretion	Kidney
Identifiers
IUPAC name 3,5-dimethyltricyclo[3.3.1.1^3,7]decan-1amine or 3,5-dimethyladamantan-1-amine
CAS Number	19982-08-2^Y
PubChem CID	4054
IUPHAR/BPS	4253
DrugBank	DB01043^Y
ChemSpider	3914^Y
UNII	W8O17SJF3T
KEGG	D08174^Y
ChEMBL	CHEMBL807^Y
Chemical and physical data
Formula	C₁₂H₂₁N
Molar mass	179.3 g/mol
3D model (JSmol)	Interactive image
SMILES NC12CC3(CC(C1)(CC(C2)C3)C)C
InChI InChI=1S/C12H21N/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8,13H2,1-2H3^Y Key:BUGYDGFZZOZRHP-UHFFFAOYSA-N^Y
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