ଡୋନେପେଜିଲ

ଡୋନେପେଜିଲ
Clinical data
Trade names	Aricept, others
AHFS/Drugs.com	monograph
MedlinePlus	a697032
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth (tablets)
ATC code	N06DA02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	100%
Protein binding	96%
Elimination half-life	70 hours
Excretion	0.11-0.13 (L/h/kg)
Identifiers
	IUPAC name (RS)-2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;
CAS Number	120014-06-4 ;
PubChem CID	3152;
IUPHAR/BPS	6599;
DrugBank	DB00843 ;
ChemSpider	3040 ;
UNII	8SSC91326P;
KEGG	D07869 ;
ChEBI	CHEBI:53289 ;
ChEMBL	CHEMBL502 ;
PDB ligand	E20 (PDBe, RCSB PDB);
ECHA InfoCard	100.125.198
Chemical and physical data
Formula	C24H29NO3
Molar mass	୩୭୯.୫0 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C2c1cc(OC)c(OC)cc1CC2CC4CCN(Cc3ccccc3)CC4;
	InChI InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 ; Key:ADEBPBSSDYVVLD-UHFFFAOYSA-N ;
(verify)

ଡୋନେପେଜିଲ (ଇଂରାଜୀ ଭାଷାରେ Donepezil, ଏକ ବିକ୍ରୟ ନାମ ଆରିସେପ୍ଟ/ Aricept ଯାହା ଆଲଜିମର ରୋଗ ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ ।^[୧] ଏହା ମାନସିକ ସ୍ଥିତିରେ ସାମାନ୍ୟ ଉନ୍ନତି ଆଣେ ।^[୨] ଏହାର ବ୍ୟବ‌ହାରରେ କିନ୍ତୁ ରୋଗର ପ୍ରଗତିରେ କିଛି ପରିବର୍ତ୍ତନ ଆସେନି ।^[୩] କୌଣସି ଉପକାର ନମିଳିଲେ ଏହି ଔଷଧ ବନ୍ଦ କରିବାକୁ ଉପଦେଶ ଦିଆଯାଏ । ^[୪] ଏହାକୁ ପାଟିରେ ଦିଆଯାଏ । ^[୧]

ଡୋନେପେଜିଲର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ନିଦ୍ରା ସମସ୍ୟା, ତରଳ ଝାଡ଼ା, ଆକ୍ରମଣଶୀଳ, ଥକ୍କା ଅନୁଭବ ଓ ମାଂସପେଶୀ କ୍ରାମ୍ପ ହୋଇପାରେ । ^[୧]^[୪] ସାଂଘାତିକ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ହେଲେ ଅନିୟମିତ ହୃଦ୍‌ଗତି (heart arrythmia), ମୂତ୍ରାବଧାରଣ (urinary retention) ବା ବାତ (seizures) ହୋଇପାରେ ।^[୧] ଡୋନେପେଜିଲ ଏକ କେନ୍ଦ୍ରୀୟ ଆସେଟାଇଲ୍ଲକୋଲିନଇସ୍ଟରେଜ ଅବରୋଧକାରୀ (acetylcholinesterase inhibitor) ଔଷଧ ।^[୧]

ସନ ୧୯୯୬ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଡୋନେପେଜିଲ ଔଷଧ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୧] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୪] ସନ ୨୦୧୯ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ଏହାର ଏକ ମାସର ଖର୍ଚ୍ଚ ବାବଦକୁ ପ୍ରାୟ ୮.୪୪ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼େ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୧.୩୮ ଆମେରିକୀୟ ଡଲାର ।^[୫] ସନ ୨୦୧୬ରେ ଏହାର ୭ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିପସନ ତାଲିକାରେ ୯୮ତମ ସ୍ଥାନରେ ତାଲିକାଭୁକ୍ତ ହୋଇଥିଲା ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Donepezil Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 4 February 2019.
↑ Birks, JS; Harvey, RJ (18 June 2018). "Donepezil for dementia due to Alzheimer's disease". The Cochrane Database of Systematic Reviews. 6: CD001190. doi:10.1002/14651858.CD001190.pub3. PMID 29923184.
↑ Swedish Council on Health Technology Assessment (June 2008). "Dementia -- Caring, Ethics, Ethnical and Economical Aspects: A Systematic Review". PMID 28876770. {{cite journal}}: Cite journal requires |journal= (help)
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 300. ISBN 9780857113382.
↑ "NADAC as of 2019-01-30". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-27. Retrieved 4 February 2019.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

Brenner, George D.; George M. Brenner (2000). Pharmacology. Philadelphia: W. B. Saunders. ISBN 978-0-7216-7757-6.
Acting Editor-in-Chief Louise Welbanks. (2000). Compendium of Pharmaceuticals and Specialities, 2000 (25th ed.). Canadian Pharmaceutical Assn. ISBN 978-0-919115-76-7. {{cite book}}: |author= has generic name (help)
Aricept entry at Drugs.com
3D Molecular structure of Donepezil
Acetylcholinesterase: A gorge-ous enzyme Article describing structure of target enzyme acetylcholinesterase at PDBe

[AHFS2019-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Donepezil Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 4 February 2019.

[2] Birks, JS; Harvey, RJ (18 June 2018). "Donepezil for dementia due to Alzheimer's disease". The Cochrane Database of Systematic Reviews. 6: CD001190. doi:10.1002/14651858.CD001190.pub3. PMID 29923184.

[3] Swedish Council on Health Technology Assessment (June 2008). "Dementia -- Caring, Ethics, Ethnical and Economical Aspects: A Systematic Review". PMID 28876770. {{cite journal}}: Cite journal requires |journal= (help)

[BNF76-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 300. ISBN 9780857113382.

[5] "NADAC as of 2019-01-30". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-03-27. Retrieved 4 February 2019.

[6] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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