ମେଡ୍ରକ୍ସିପ୍ରୋଜେସ୍ଟେରନ ଆସେଟେଟ

ମେଡ୍ରକ୍ସିପ୍ରୋଜେସ୍ଟେରନ ଆସେଟେଟ
Clinical data
Trade names	Provera, Depo-Provera, Depo-SubQ Provera 104, Curretab, Cycrin, Farlutal, Gestapuran, Perlutex, Veramix, others
Synonyms	NSC-26386
AHFS/Drugs.com	monograph
MedlinePlus	a604039
Pregnancy; category	US: X (Contraindicated) ; ;
Routes of; administration	by mouth, intramuscular, subcutaneous
ATC code	G03AC06 (WHO) G03DA02, L02AB02;
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	99%
Protein binding	88% (to albumin)
Elimination half-life	By mouth: 12–33 hours; I.M.: ~50 days; S.C.: ~40 days
Identifiers
	IUPAC name [(6S,8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate;
CAS Number	71-58-9;
PubChem CID	6279;
IUPHAR/BPS	2879;
DrugBank	DB00603;
ChemSpider	6043;
UNII	C2QI4IOI2G;
KEGG	C08150 ;
ChEBI	CHEBI:6716;
ChEMBL	CHEMBL717 ;
ECHA InfoCard	100.000.689
Chemical and physical data
Formula	C24H34O4
Molar mass	386.52 g/mol
3D model (JSmol)	Interactive image;
	SMILES C[C@H]1C[C@@H]2[C@H](CC[C@]3([C@H]2CC[C@@]3(C(=O)C)OC(=O)C)C)[C@@]4(C1=CC(=O)CC4)C;
	InChI InChI=InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1; Key:PSGAAPLEWMOORI-PEINSRQWSA-N;
(verify)

ମେଡ୍ରକ୍ସିପ୍ରୋଜେସ୍ଟେରନ ଆସେଟେଟ (ଇଂରାଜୀ ଭାଷାରେ Medroxyprogesterone acetate ବା MPA), ବିକ୍ରୟ ନାମ ଡେପୋ-ପ୍ରୋଭେରା/Depo-Provera) ଏକ କୃତ୍ରିମ ପ୍ରଜେସ୍ଟିନ (progestin) ଟାଇପର ହରମୋନ (hormone) ଯାହା କାରଖାନାରେ ପ୍ରସ୍ତୁତ କରାଯାଏ । ଏହା ଜନ୍ମ ନିରୋଧ (birth control) ନିମନ୍ତେ ଓ ଋତୁବନ୍ଦ ଲକ୍ଷଣ (menopausal symptoms) ଉପସମ ନିମନ୍ତେ ହରମୋନ ବଦଳ ଥେରାପି (hormone replacement therapy) ଭାବରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।ଏଣ୍ଡୋମେଟ୍ରିଓସିସ, ଅସାଧାରଣ ଜରାୟୁ ରକ୍ତସ୍ରାବ (abnormal uterine bleeding), ପାରାଫିଲିଆ (abnormal sexuality in males) ଓ କେତେକ କର୍କଟ ରୋଗର ଚିକିତ୍ସାରେ ଦିଆଯାଏ । ଏହା ପାଟିରେ ବା ମାଂସପେଶୀ ଇଞ୍ଜେକସନ (into a muscle) ବା ଚର୍ମତଳ ଇଞ୍ଜେକସନ (under the skin) ଆକାରରେ ଦିଆଯାଏ ।^[୮]

ମେଡ୍ରକ୍ସିପ୍ରୋଜେସ୍ଟେରନ ଆସେଟେଟର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଋତୁରୋଧ (no periods), ପେଟ ଯନ୍ତ୍ରଣା, ମୁଣ୍ଡବଥା ଓ ଉଦ୍‌ବେଗ (anxiety) ଇତ୍ୟାଦି ଲକ୍ଷଣ ଦେଖାଯାଏ । ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟାରେ ଓଷ୍ଟିଓପୋରୋସିସ, ରକ୍ତ ଜମାଟ (blood clots), ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, ଅବସାଦ (depression) ଓ ଯକୃତ ସମସ୍ୟା (liver problems) ଦେଖାଯାଇପାରେ । ଗର୍ଭାବସ୍ଥାରେ ଦେଲେ ଶିଶୁର ହାନୀ ହୋଇପାରେ । ଦେହରୁ ନିର୍ଗତ ହେଉଥିବାଗୋନାଡୋଟ୍ରପିନ (gonadotropins) କ୍ଷରଣ ଏହା କମେଇ ଦେଇ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୮]

ସନ ୧୯୫୮ରେ ମେଡ୍ରକ୍ସିପ୍ରୋଜେସ୍ଟେରନ ଆସେଟେଟ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଓ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୯] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୧୦] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ଭାଏଲର ମୂଲ୍ୟ ୦.୫୯ରୁ ୧.୫୭ ଆମେରିକୀୟ ଡଲାର ।^[୧୧] ଇଂଲଣ୍ଡରେ ଏହି ଡୋଜର ମୂଲ୍ୟ ପ୍ରାୟ ୬.୦୧ ପାଉଣ୍ଡ । ^[୧୨] ସନ ୨୦୧୫ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହି ଡୋଜର ମୂଲ୍ୟ ପ୍ରାୟ ୨୫ ଆମେରିକୀୟ ଡଲାରରୁ କମ୍ ଥିଲା । ^[୧୩]

ଆଧାର

↑ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 638–. ISBN 978-3-88763-075-1.
↑ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 657. ISBN 978-1-4757-2085-3.
↑ ^୩.୦ ^୩.୧ Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH (2008). "Classification and pharmacology of progestins". Maturitas. 61 (1–2): 171–80. doi:10.1016/j.maturitas.2008.11.013. PMID 19434889.
↑ "Provera" (PDF). FDA. 2007. Retrieved 23 December 2016.
↑ Kuhl H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947.
↑ "Depo_Provera" (PDF). FDA. 2002. Retrieved 23 December 2016.
↑ "depo-subQ Provera" (PDF). FDA. 2009. Retrieved 23 December 2016.
↑ ^୮.୦ ^୮.୧ "Medroxyprogesterone Acetate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 478. ISBN 978-3-527-60749-5. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Medroxyprogesterone Acetate". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ British National Formulary : BNF 69 (69th ed.). British Medical Association. 2015. p. 555. ISBN 978-0-85711-156-2.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 363. ISBN 9781284057560. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[IndexNominum2000-1] Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 638–. ISBN 978-3-88763-075-1.

[Elks2014-2] Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 657. ISBN 978-1-4757-2085-3.

[pmid19434889-3] ୩.୦ ^୩.୧ Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH (2008). "Classification and pharmacology of progestins". Maturitas. 61 (1–2): 171–80. doi:10.1016/j.maturitas.2008.11.013. PMID 19434889.

[ProveraLabel-4] "Provera" (PDF). FDA. 2007. Retrieved 23 December 2016.

[pmid16112947-5] Kuhl H (August 2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947.

[DepoProveraLabel-6] "Depo_Provera" (PDF). FDA. 2002. Retrieved 23 December 2016.

[DepoSubQProveraLabel-7] "depo-subQ Provera" (PDF). FDA. 2009. Retrieved 23 December 2016.

[AHFS2016-8] ୮.୦ ^୮.୧ "Medroxyprogesterone Acetate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[Fis2006-9] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 478. ISBN 978-3-527-60749-5. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[WHO19th-10] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-11] "Medroxyprogesterone Acetate". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[BNF69-12] British National Formulary : BNF 69 (69th ed.). British Medical Association. 2015. p. 555. ISBN 978-0-85711-156-2.

[Ric2015-13] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 363. ISBN 9781284057560. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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