ଇଟ୍ରାକୋନାଜଲ

ଇଟ୍ରାକୋନାଜଲ
Clinical data
Trade names	Sporanox, Orungal, others
AHFS/Drugs.com	monograph
MedlinePlus	a692049
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth (capsules, solution), local (vaginal suppository), IV; By mouth only (UK and US)
ATC code	J02AC02 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	~55%, maximal if taken with full meal
Protein binding	99.8%
Metabolism	Extensive in liver (CYP3A4)
Metabolites	Hydroxy-itraconazole, keto-itraconazole,; N-desalkyl-itraconazole
Elimination half-life	21 hours
Excretion	Urine (35%), faeces (54%)
Identifiers
	IUPAC name (±)-1-[(RS)-sec-butyl]-4-[p-[4-[p-[[(2R,4S)-rel-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-Δ2-1,2,4-triazolin-5-one;
CAS Number	84625-61-6 ;
PubChem CID	55283;
DrugBank	DB01167 ;
ChemSpider	49927 ;
UNII	304NUG5GF4;
KEGG	D00350 ;
ChEBI	CHEBI:6076 ;
ChEMBL	CHEMBL22587 ;
ECHA InfoCard	100.123.596
Chemical and physical data
Formula	C35H38Cl2N8O4
Molar mass	705.64
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=C1N(/N=C\N1c2ccc(cc2)N7CCN(c6ccc(OC[C@@H]3O[C@](OC3)(c4ccc(Cl)cc4Cl)Cn5ncnc5)cc6)CC7)C(C)CC;
	InChI InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1 ; Key:VHVPQPYKVGDNFY-ZPGVKDDISA-N ;
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ଇଟ୍ରାକନାଜଲ (ଇଂରାଜୀ ଭାଷାରେ Itraconazole) ଏକ କବକ ବିରୋଧୀ ବା ଆଣ୍ଟିଫଙ୍ଗାଲ ଔଷଧ (antifungal medication) ଯାହା କବକ ସଂକ୍ରମଣ (fungal infections) ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୩] ଆସ୍ପରଜିଲ୍ଲୋସିସ (aspergillosis), ବ୍ଲାସ୍ଟୋମାଇକୋସିସ (blastomycosis), କ‌କ୍ସିଡିଓମାଇକୋସିସ (coccidioidomycosis), ହିସ୍ଟୋପ୍ଲାଜମୋସିସ (histoplasmosis) ଓ ପାରାକ‌କ୍ସିଡିଓମାଇକୋସିସ (en:paracoccidioidomycosis) ଇତ୍ୟାଦି ରୋଗ କବକ ସଂକ୍ରମଣ ଯୋଗୁ ହୁଏ ।^[୩] ଏହି ଔଷଧ ପାଟିରେ ବା ଶିରାଭ୍ୟନ୍ତରରେ ଇଞ୍ଜେକସନ (intravenously) ଆକାରରେ ଦିଆଯାଏ ।^[୩]

ଇଟ୍ରାକନାଜଲ ଔଷଧରେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ତରଳ ଝାଡ଼ା, ଉଦର ଯନ୍ତ୍ରଣା, ରାସ୍ ଓ ମୁଣ୍ଡବିନ୍ଧା ହୁଏ । ^[୩] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ଯକୃଟ ସମସ୍ୟା (liver problem), ହୃଦ୍‌ପାତ, ସ୍ଟିଭେନ୍ସ ଜନସନ ସିଣ୍ଡ୍ରୋମ ଓ ଆନାଫାଇଲାକ୍‌ସିସ ଭଳି ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା (allergic reactions) ଦେଖାଯାଇପାରେ । ^[୩] ଗର୍ଭାବସ୍ଥା ବା ସ୍ତନ୍ୟପାନ (breastfeeding) ସମୟରେ ଏହା ନେଲେ ନିରାପଦ କି ନୁହେଁ ତାହା ନିଶ୍ଚିତ ହୋଇନାହିଁ । ^[୪] ଏହା ଟ୍ରିଆଜୋଲ (triazole) ଶ୍ରେଣୀର ଏକ ଔଷଧ ।^[୩] ଏହା କୋଷ ପରଦାକୁ (cell membrane) ପ୍ରଭାବିତ କରି କବକର ବୃଦ୍ଧିକୁ ରୋକିଦିଏ (stops fungal growth) ବା ତାହାର ମେଟାବୋଲିଜ୍ମକୁ ପ୍ରଭାବିତ କରେ । ^[୩]

ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଇଟ୍ରାକନାଜଲ ସନ ୧୯୯୨ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୩] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ସନ ୨୦୧୫ରେ ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ଦିନ ଡୋଜର କ୍ରୟ ମୂଲ୍ୟ ୦.୨୯ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୬] ସନ ୨୦୧୭ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ହୋଲସେଲ ମୂଲ୍ୟ ୬.୩୬ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୭]

ଏହାକୁ ମଧ୍ୟ ଦେଖନ୍ତୁ

ଆଧାର

↑ Isoherranen, N; Kunze, KL; Allen, KE; Nelson, WL; Thummel, KE (October 2004). "Role of Itraconazole Metabolites in CYP3A4 Inhibition" (PDF). Drug Metabolism and Disposition. 32 (10): 1121–31. doi:10.1124/dmd.104.000315. PMID 15242978. Retrieved 28 August 2016.
↑ "Sporanox (itraconazole) Capsules. Full Prescribing Information" (PDF). Janssen Pharmaceuticals, Inc. Archived from the original (PDF) on 17 May 2018. Retrieved 28 August 2016.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ "Itraconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.
↑ "Itraconazole Use During Pregnancy". Drugs.com. Retrieved 10 December 2017.
↑ "WHO Model List of Essential Medicines (20th List)" (PDF). World Health Organization. March 2017. Retrieved 29 June 2017.
↑ "Single Drug Information". International Medical Products Price Guide. Archived from the original on 10 December 2017. Retrieved 9 December 2017.
↑ "NADAC as of 2017-12-06". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2017-12-10. Retrieved 10 December 2017.

ବାହ୍ୟ ଲିଙ୍କ

General pharmacologic information about itraconazole, National Institutes of Health
Itraconazole Oral Route, Mayo Clinic

[1] Isoherranen, N; Kunze, KL; Allen, KE; Nelson, WL; Thummel, KE (October 2004). "Role of Itraconazole Metabolites in CYP3A4 Inhibition" (PDF). Drug Metabolism and Disposition. 32 (10): 1121–31. doi:10.1124/dmd.104.000315. PMID 15242978. Retrieved 28 August 2016.

[Sporanox_PI-2] "Sporanox (itraconazole) Capsules. Full Prescribing Information" (PDF). Janssen Pharmaceuticals, Inc. Archived from the original (PDF) on 17 May 2018. Retrieved 28 August 2016.

[AHFS2017-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ "Itraconazole". The American Society of Health-System Pharmacists. Retrieved 8 December 2017.

[4] "Itraconazole Use During Pregnancy". Drugs.com. Retrieved 10 December 2017.

[WHO20th-5] "WHO Model List of Essential Medicines (20th List)" (PDF). World Health Organization. March 2017. Retrieved 29 June 2017.

[6] "Single Drug Information". International Medical Products Price Guide. Archived from the original on 10 December 2017. Retrieved 9 December 2017.

[7] "NADAC as of 2017-12-06". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2017-12-10. Retrieved 10 December 2017.

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