ଆଇଫୋସଫାମାଇଡ

ଆଇଫୋସଫାମାଇଡ
	(R)-(+)- and (S)-(−)-ifosfamide (top),; (S)-(−)-ifosfamide (bottom)
Clinical data
Pronunciation	/aɪˈfɒsfəˌmaɪd/
Trade names	Ifex, others
Synonyms	3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
AHFS/Drugs.com	monograph
MedlinePlus	a695023
Pregnancy; category	AU: D ; US: D (Evidence of risk) ; ;
Routes of; administration	intravenously
ATC code	L01AA06 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; NZ: Prescription medicine; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	100%
Metabolism	Hepatic
Elimination half-life	60-80% in 72 hours
Excretion	Renal
Identifiers
	IUPAC name N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide 2-oxide;
CAS Number	3778-73-2 ;
PubChem CID	3690;
IUPHAR/BPS	7201;
DrugBank	DB01181 ;
ChemSpider	3562 ;
UNII	UM20QQM95Y;
KEGG	D00343 ;
ChEBI	CHEBI:5864 ;
ChEMBL	CHEMBL1024 ;
ECHA InfoCard	100.021.126
Chemical and physical data
Formula	C7H15Cl2N2O2P
Molar mass	261.1 g mol−1
3D model (JSmol)	Interactive image;
	SMILES O=P1(OCCCN1CCCl)NCCCl;
	InChI InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12) ; Key:HOMGKSMUEGBAAB-UHFFFAOYSA-N ;
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ଆଇଫୋସଫାମାଇଡର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କେଶହାନୀ, ବାନ୍ତି, ପରିସ୍ରାରେ ରକ୍ତ, ସଂକ୍ରମଣ ଓ ବୃକ୍‌କ ସମସ୍ୟା ଆଦି ଲକ୍ଷଣମାନ ଦେଖାଯାଏ । ଅନ୍ୟାନ୍ୟ ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ଅସ୍ଥିମଜ୍ଜା ଦମନ (bone marrow suppression) ଓ କମ ଚେତନାବସ୍ଥା (decreased level of consciousness) କେଖାଯାଏ । ଗର୍ଭାବସ୍ଥାରେ ଦେଲେ ଏହା ଶିଶୁର ହାନୀ କରାଏ ।^[୧] ଏହା ଆଲକିଲେଟିଙ୍ଗ ଆଣ୍ଟିନିଓପ୍ଲାସ୍ଟିକ ଏଜେଣ୍ଟ (alkylating agent) ଓ ନାଇଟ୍ରୋଜେନ ମସ୍ଟାର୍ଡ଼ (nitrogen mustard) ଶ୍ରେଣୀର ଏକ ଔଷଧ ।^[୧]^[୨] ଏହା ଡିଏନଏର (DNA) ବିଭକ୍ତିକରଣକୁ ନଷ୍ଟ କରେ ଓ ଆରଏନଏର (RNA) ସୃଷ୍ଟିକୁ ଅବରୋଧ କରେ ।^[୧]

ଆଇଫୋସଫାମାଇଡ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୧୯୮୭ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୧] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୩] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ୨ ଗ୍ରାମ ଭାଏଲର ହୋଲସେଲ ମୂଲ୍ୟ ୭.୩୫ରୁ ୭୦.୭୦ ଆମେରିକୀୟ ଡଲାର ।^[୪] ଇଂଲଣ୍ଡରେ ଏହାର ମୂଲ୍ୟ ୧୩୦.୦୪ ପାଉଣ୍ଡ ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Ifosfamide". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ Dowd, Frank J.; Johnson, Bart; Mariotti, Angelo (2016). Pharmacology and Therapeutics for Dentistry (in ଇଂରାଜୀ) (7 ed.). Elsevier Health Sciences. p. 533. ISBN 9780323445955.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Ifosfamide". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 580. ISBN 9780857111562.

Clinical data

(R)-(+)- and (S)-(−)-ifosfamide (top), (S)-(−)-ifosfamide (bottom)
Pronunciation	/aɪˈfɒsfəˌmaɪd/
Trade names	Ifex, others
Synonyms	3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide
AHFS/Drugs.com	monograph
MedlinePlus	a695023
Pregnancy category	AU: D US: D (Evidence of risk)
Routes of administration	intravenously
ATC code	L01AA06 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only NZ: Prescription medicine UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	100%
Metabolism	Hepatic
Elimination half-life	60-80% in 72 hours
Excretion	Renal
Identifiers
IUPAC name N,3-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amide 2-oxide
CAS Number	3778-73-2^Y
PubChem CID	3690
IUPHAR/BPS	7201
DrugBank	DB01181^Y
ChemSpider	3562^Y
UNII	UM20QQM95Y
KEGG	D00343^Y
ChEBI	CHEBI:5864^Y
ChEMBL	CHEMBL1024^Y
ECHA InfoCard	100.021.126
Chemical and physical data
Formula	C₇H₁₅Cl₂N₂O₂P
Molar mass	261.1 g mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=P1(OCCCN1CCCl)NCCCl
InChI InChI=1S/C7H15Cl2N2O2P/c8-2-4-10-14(12)11(6-3-9)5-1-7-13-14/h1-7H2,(H,10,12)^Y Key:HOMGKSMUEGBAAB-UHFFFAOYSA-N^Y
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