ଗ୍ରିସିଓଫଲଭିନ

ଗ୍ରିସିଓଫଲଭିନ
Clinical data
Trade names	Gris-peg, Grifulvin V, others
AHFS/Drugs.com	monograph
MedlinePlus	a682295
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	by mouth
ATC code	D01AA08 (WHO) D01BA01;
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	Highly variable (25 to 70%)
Metabolism	liver (demethylation and glucuronidation)
Elimination half-life	9–21 hours
Identifiers
	IUPAC name (2S,6'R)- 7-chloro- 2',4,6-trimethoxy- 6'-methyl- 3H,4'H-spiro [1-benzofuran- 2,1'-cyclohex[2]ene]- 3,4'-dione;
CAS Number	126-07-8 ;
PubChem CID	441140;
DrugBank	DB00400 ;
ChemSpider	389934 ;
UNII	32HRV3E3D5;
KEGG	D00209 ;
ChEBI	CHEBI:27779 ;
ChEMBL	CHEMBL562 ;
ECHA InfoCard	100.004.335
Chemical and physical data
Formula	C17H17ClO6
Molar mass	352.766 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C2c3c(O[C@@]21C(/OC)=C\C(=O)C[C@H]1C)c(Cl)c(OC)cc3OC;
	InChI InChI=1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1 ; Key:DDUHZTYCFQRHIY-RBHXEPJQSA-N ;
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ଗ୍ରିସିଓଫଲଭିନ (ଇଂରାଜୀ ଭାଷାରେ Griseofulvin) ଏକ କବକରୋଧୀ ଔଷଧ (antifungal medication ଯାହା ଅନେକ ପ୍ରକାରର ଡର୍ମାଟୋଫାଇଟିସ (dermatophytoses) ବା ringworm) ବା ଯାଦୁ ରୋଗର ଚିକିତ୍ସାରେ ବ୍ୟବ‌ହାର କରାଯାଏ । ^[୧] କ୍ରିମ ଔଷଧଦ୍ୱାରା ଚର୍ମ ଓ ନ‌ଖ ଯାଦୁ (nails) ଭଲ ନ ହେଲେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୨] ଗ୍ରିସିଓଫଲଭିନ ପାଟିରେ ଦିଆଯାଏ । ^[୧]

ଗ୍ରିସିଓଫଲଭିନର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା (allergic reactions), ଅଇ, ତରଳ ଝାଡ଼ା, ମୁଣ୍ଡବଥା, ନିଦ୍ରାସମସ୍ୟା ଓ ଥକ୍କା ଅନୁଭବ ଇତ୍ୟାଦି ଲକ୍ଷଣ ଦେଖାଯାଏ । ପରଫିରିଆ (porphyria) ଓ ଯକୃତ ଫେଲ (liver failure) ରୋଗରେ ଏହା ଦିଆଯାଏ ନାହିଁ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ଓ ପୂର୍ବରୁ ଏହି ଔଷଧଦ୍ୱାରା ଶିଶୁର କ୍ଷତି ସାଧନ ହୁଏ ।^[୧]^[୨] କବକର ମାଇଟୋସିସ (mitosis) ପ୍ରଣାଳୀରେ ଏହା ବାଧା ସୃଷ୍ଟି କରେ ।^[୧]

ସନ ୧୯୩୯ରେ ଏକ ପ୍ରକାର ପେନିସଲିଅମ (Penicillium) ମୋଲ୍‌ଡରୁ ଗ୍ରିସିଓଫଲଭିନ ଆବିଷ୍କୃତ ହୋଇଥିଲା ।^[୩]^[୪] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୫] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ଦିନ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୦.୦୫ରୁ ୦.୧୮ ଆମେରିକୀୟ ଡଲାର ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ କୋର୍ଷର ମୂଲ୍ୟ ୧୦୦ରୁ ୨୦୦ ଡଲାର ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Griseofulvin". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ ^୨.୦ ^୨.୧ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 149. ISBN 9789241547659. Retrieved 8 December 2016.
↑ Block, Seymour Stanton (2001). Disinfection, Sterilization, and Preservation (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 631. ISBN 9780683307405.
↑ Michael Ash; Irene Ash (2004). Handbook of Preservatives. Synapse Info Resources. p. 406. ISBN 978-1-890595-66-1.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Griseofulvin". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 44. ISBN 9781284057560.

[AHFS2016-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Griseofulvin". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[WHO2008-2] ୨.୦ ^୨.୧ WHO Model Formulary 2008 (PDF). World Health Organization. 2009. p. 149. ISBN 9789241547659. Retrieved 8 December 2016.

[3] Block, Seymour Stanton (2001). Disinfection, Sterilization, and Preservation (in ଇଂରାଜୀ). Lippincott Williams & Wilkins. p. 631. ISBN 9780683307405.

[AshAsh2004-4] Michael Ash; Irene Ash (2004). Handbook of Preservatives. Synapse Info Resources. p. 406. ISBN 978-1-890595-66-1.

[WHO19th-5] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-6] "Griseofulvin". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[Ric2015-7] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 44. ISBN 9781284057560.

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