ଫର୍ମୋଟେରୋଲ

<span title="International nonproprietary name (INN): <nowiki>Mr. Ibrahem/Formoterol</nowiki>">Mr. Ibrahem/Formoterol
	Formoterol (top),; ; (R,R)-(−)-formoterol (center) and; ; (S,S)-(+)-formoterol (bottom)
Clinical data
Trade names	Oxeze, Perforomist, others
AHFS/Drugs.com	Monograph
License data	<abbr class="country-name" title="<nowiki>European Union</nowiki>">EU EMA: by formoterol fumarate dihydrate[permanent dead link];
Pregnancy; </nowiki>; </nowiki>category	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: B3;
Routes of; </nowiki>; </nowiki>administration	Inhalation (capsules for oral inhalation, DPI, MDI)
Drug class	LABA
Legal status
Legal status	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: S4 (Prescription only); <abbr class="country-name" title="<nowiki>United Kingdom</nowiki>">UK: POM (Prescription only); <abbr class="country-name" title="<nowiki>United States</nowiki>">US: ℞-only; <abbr class="country-name" title="<nowiki>European Union</nowiki>">EU: Rx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Protein binding	61% to 64%
Metabolism	Liver demethylation and glucuronidation (CYP2D6, CYP2C19, CYP2C9 and CYP2A6 involved)
Onset of action	Up to 3 hr for max. effect
Elimination half-life</nowiki>	10 h
Duration of action	12 h
Excretion	Kidney and fecal
Identifiers
	IUPAC name (RR,SS)-N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl) propan-2-ylamino]ethyl] phenyl]formamide;
Chemical and physical data
Formula	C19H24N2O4
Molar mass	344.411 g·mol−1
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O=CNc1cc(ccc1O)[C@@H](O)CN[C@H](C)Cc2ccc(OC)cc2;
	InChI InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1 ; Key:BPZSYCZIITTYBL-YJYMSZOUSA-N ;
	(verify)

ଫର୍ମୋଟେରୋଲ
	Formoterol (top),; (R,R)-(−)-formoterol (center) and; (S,S)-(+)-formoterol (bottom)
Clinical data
Trade names	Oxeze, Perforomist, others
AHFS/Drugs.com	monograph
data	EU EMA: yes;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	Inhalation (capsules for oral inhalation, DPI, MDI)
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	61% to 64%
Metabolism	Liver demethylation and glucuronidation (CYP2D6, CYP2C19, CYP2C9 and CYP2A6 involved)
Onset of action	Up to 3 hr for max. effect
Elimination half-life	10 h
Duration of action	12 h
Excretion	Kidney and fecal
Identifiers
	IUPAC name (RR,SS)-N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl) propan-2-ylamino]ethyl] phenyl]formamide;
ECHA InfoCard	100.131.654
Chemical and physical data
Formula	C19H24N2O4
Molar mass	୩୪୪.୪୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=CNc1cc(ccc1O)[C@@H](O)CN[C@H](C)Cc2ccc(OC)cc2;
	InChI InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1 ; Key:BPZSYCZIITTYBL-YJYMSZOUSA-N ;
(verify)

ଫର୍ମୋଟେରୋଲ, ଅନ୍ୟ ନାମ ଇଫର୍ମୋଟରୋଲ ଏକ ଔଷଧ ଯାହା ଆଜମା ଏବଂ କ୍ରନିକ ଅବଷ୍ଟ୍ରକ୍ଟିଭ ଫୁସଫୁସ ରୋଗର (COPD) ଦୀର୍ଘକାଳୀନ ପରିଚାଳନାରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୪] ଏହାକୁ ପ୍ରଶ୍ୱାସ ସାହାଯ୍ୟରେ ଫୁସଫୁସକୁ ନିଆଯାଏ ।^[୪] ପୂର୍ଣ୍ଣ ପ୍ରଭାବ ମିଳିବା ପାଇଁ ପ୍ରାୟ ୨ ଘଣ୍ଟା ଲାଗିଥାଏ ଏବଂ ପ୍ରାୟ ୧୨ ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି, ଶୋଇବାରେ ଅସୁବିଧା, ଅଇ, ଏବଂ ଗଳା ପ୍ରଦାହ ଅନ୍ତର୍ଭୁକ୍ତ | ^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବ୍ରଙ୍କୋସ୍ପାଜ୍ମ, ଆନାଫିଲାକ୍ସିସ୍ ଏବଂ କ୍ୟୁଟି ବିସ୍ତାର ହୋଇପାରେ ।^[୨] ଆଜମା ରୋଗରେ ଯଦି ପ୍ରଶ୍ୱାସପ୍ରାପ୍ତ ଷ୍ଟିରଏଡ ବିନା ବ୍ୟବହୃତ ହେଲେ ମୃତ୍ୟୁ ଆଶଙ୍କା ବଡ଼ିଯାଇପାରେ । ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଅସ୍ପଷ୍ଟ ସୁରକ୍ଷା ଅଟେ ।^[୨] ଏହା ଏକ ଦୀର୍ଘ କାର୍ଯ୍ୟକାରୀ β_୨ ଆଗୋନିଷ୍ଟ (LABA) ଅଟେ ।^[୨]

୧୯୭୨ ମସିହାରେ ଫର୍ମୋଟେରୋଲ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୮୮ରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲା ।^[୫] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରତି ମାସରେ ପ୍ରାୟ ୧୨ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହେଉଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୨୮୫ ଡଲାର ଅଟେ । ^[୬] ଏହା ବୁଡେସୋନାଇଡ/ଫର୍ମୋଟେରୋଲ ଏବଂ ମୋମେଟାସୋନ/ଫର୍ମୋଟେରୋଲ ସ‌ହିତ ମିଳିତ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ^[୨]

ଆଧାର

↑ "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-07-12.{{cite web}}: CS1 maint: archived copy as title (link)
↑ ^୨.୦୦ ^୨.୦୧ ^୨.୦୨ ^୨.୦୩ ^୨.୦୪ ^୨.୦୫ ^୨.୦୬ ^୨.୦୭ ^୨.୦୮ ^୨.୦୯ ^୨.୧୦ ^୨.୧୧ "Formoterol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2021. Retrieved 13 December 2021.
↑ "Archive copy" (PDF).
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 267. ISBN 978-0857114105.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 543. ISBN 9783527607495. Archived from the original on 2021-07-24. Retrieved 2021-07-12.
↑ ^୬.୦ ^୬.୧ "Formoterol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.

[1] "Archive copy" (PDF). Archived (PDF) from the original on 2021-10-31. Retrieved 2021-07-12.{{cite web}}: CS1 maint: archived copy as title (link)

[AHFS2021-2] ୨.୦୦ ^୨.୦୧ ^୨.୦୨ ^୨.୦୩ ^୨.୦୪ ^୨.୦୫ ^୨.୦୬ ^୨.୦୭ ^୨.୦୮ ^୨.୦୯ ^୨.୧୦ ^୨.୧୧ "Formoterol Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 28 November 2021. Retrieved 13 December 2021.

[3] "Archive copy" (PDF).

[BNF81-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 267. ISBN 978-0857114105.

[Fis2006-5] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 543. ISBN 9783527607495. Archived from the original on 2021-07-24. Retrieved 2021-07-12.

[GX2021-6] ୬.୦ ^୬.୧ "Formoterol Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.

[୪]

[୨]

[୧]

[୩]

[୫]

[୬]

Clinical data

Formoterol (top), (R,R)-(−)-formoterol (center) and (S,S)-(+)-formoterol (bottom)
Trade names	Oxeze, Perforomist, others
AHFS/Drugs.com	monograph
data	EU EMA: yes
Pregnancy category	AU: B3
Routes of administration	Inhalation (capsules for oral inhalation, DPI, MDI)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only EU: Rx-only ^[୧] ℞ (Prescription only)
Pharmacokinetic data
Protein binding	61% to 64%
Metabolism	Liver demethylation and glucuronidation (CYP2D6, CYP2C19, CYP2C9 and CYP2A6 involved)
Onset of action	Up to 3 hr for max. effect^[୨]
Elimination half-life	10 h
Duration of action	12 h^[୨]
Excretion	Kidney and fecal
Identifiers
IUPAC name (RR,SS)-N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl) propan-2-ylamino]ethyl] phenyl]formamide
ECHA InfoCard	100.131.654
Chemical and physical data
Formula	C₁₉H₂₄N₂O₄
Molar mass	୩୪୪.୪୧ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=CNc1cc(ccc1O)[C@@H](O)CN[C@H](C)Cc2ccc(OC)cc2
InChI InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1^Y Key:BPZSYCZIITTYBL-YJYMSZOUSA-N^Y
(verify)

Clinical data

Formoterol (top), (R,R)-(−)-formoterol (center) and (S,S)-(+)-formoterol (bottom)
Trade names	Oxeze, Perforomist, others
AHFS/Drugs.com	Monograph
License data	<abbr class="country-name" title="<nowiki>European Union</nowiki>">EU EMA: by formoterol fumarate dihydrate^{[permanent dead link]}
Pregnancy </nowiki> </nowiki>category	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: B3
Routes of </nowiki> </nowiki>administration	Inhalation (capsules for oral inhalation, DPI, MDI)
Drug class	LABA^[୨]
Legal status
Legal status	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: S4 (Prescription only) <abbr class="country-name" title="<nowiki>United Kingdom</nowiki>">UK: POM (Prescription only) <abbr class="country-name" title="<nowiki>United States</nowiki>">US: ℞-only <abbr class="country-name" title="<nowiki>European Union</nowiki>">EU: Rx-only^[୩] In general: ℞ (Prescription only)
Pharmacokinetic data
Protein binding	61% to 64%
Metabolism	Liver demethylation and glucuronidation (CYP2D6, CYP2C19, CYP2C9 and CYP2A6 involved)
Onset of action	Up to 3 hr for max. effect^[୨]
Elimination half-life</nowiki>	10 h
Duration of action	12 h^[୨]
Excretion	Kidney and fecal
Identifiers
IUPAC name (RR,SS)-N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl) propan-2-ylamino]ethyl] phenyl]formamide
Chemical and physical data
Formula	C₁₉H₂₄N₂O₄
Molar mass	344.411 g·mol⁻¹
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES O=CNc1cc(ccc1O)[C@@H](O)CN[C@H](C)Cc2ccc(OC)cc2
InChI InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)/t13-,19+/m1/s1^Y Key:BPZSYCZIITTYBL-YJYMSZOUSA-N^Y
(verify)