"ଅପସ୍ମାର" ପୃଷ୍ଠାର ସଂସ୍କରଣଗୁଡ଼ିକ ମଧ୍ୟରେ ତଫାତ
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ଟିକେ ଅଲଗା ଭାଷାର ସଂଯୋଗ ହଟାଗଲା (ଉଇକିଡାଟା ତଥ୍ୟ ଅଛି) |
→ଶରୀରତାତ୍ତ୍ଵିକ ନିଦାନ: ଲେଖାଗଲା |
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୨୯ କ ଧାଡ଼ି:
କେତେକ ଶରୀର ତ୍ରୁଟି ଯୋଗ ମଧ୍ୟ ଏହି ରୋଗ ହୁଏ । [[ରକ୍ତ-ମସ୍ତିଷ୍କ ବାଧା]]ର (Blood brain barrier) ତ୍ରୁଟି ଥିଲେ ତୀବ୍ର ଓ ସ୍ଥାୟୀ ବାତ ମାରେ<ref name="ObyJanigro2006">{{cite journal|last1=Oby|first1=Emily|last2=Janigro|first2=Damir|title=The Blood–Brain Barrier and Epilepsy|journal=Epilepsia|volume=47|issue=11|year=2006|pages=1761–1774|issn=0013-9580|doi=10.1111/j.1528-1167.2006.00817.x|url=http://onlinelibrary.wiley.com/doi/10.1111/j.1528-1167.2006.00817.x/pdf|format=PDF|pmid=17116015}}</ref><ref>{{cite journal | author = Marchi N. ''et al.'' | year = | title = Seizure-Promoting Effect of blood–brain Barrier Disruption | url = | journal = Epilepsia | volume = 48 | issue = 4| pages = 732–742 }}</ref><ref>{{cite journal | author = Seiffert E. ''et al.'' | year = | title = Lasting blood–brain barrier disruption induces epileptic focus in the rat somatosensory cortex | url = | journal = J. Neurosci | volume = 24 | issue = | pages = 7829–7836 }}</ref><ref>Uva,L. ''et al.'' Acute induction of epileptiform discharges by pilocarpine in the ''in vitro'' isolated guinea-pig brain requires enhancement of blood–brain barrier permeability. Neuroscience</ref><ref>{{cite journal | author = van Vliet E.A. ''et al.'' | year = | title = blood–brain barrier leakage may lead to progression of temporal lobe epilepsy | url = | journal = Brain | volume = 130 | issue = | pages = 521–534 }}</ref> । ଆଲବୁମିନ ଓ ଆସ୍ଟ୍ରୋସାଇଟ ଦ୍ଵୟର ପ୍ରତିକ୍ରିୟା ଯୋଗୁ ଏହା ସମ୍ଭବ ହେବା ଅନୁଶୀଳନରୁ ଜଣାଯାଏ<ref name="pmid17121744">{{cite journal| author=Ivens S| title=TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis | journal=Brain | year= 2007 | volume= 130 | issue= Pt 2 | pages= 535–47 | pmid=17121744 | doi=10.1093/brain/awl317| author-separator=,| author2=Kaufer D| author3=Flores LP| author4=Bechmann I| author5=Zumsteg D| author6=Tomkins O| display-authors=6| last7=Seiffert| first7=E.| last8=Heinemann| first8=U.| last9=Friedman| first9=A. }}</ref> । <br />
== ଶରୀରତାତ୍ତ୍ଵିକ ନିଦାନ ==
କେତେକ ଧରଣର ଅପସ୍ମାର ବାତ ଜିନ୍ ମ୍ୟୁଟେସନ ଯୋଗୁ ହେଉଥିବା ଜଣାଯାଏ । କେତେକ ଜିନ୍ରେ ଭୋଲ୍ଟେଜ୍ ଗେଟେଡ୍ ଓ ଲିଗଣ୍ଡ ଗେଟେଡ୍ ଚାନେଲର ପ୍ରୋଟିନ୍ ସବ ୟୁନିଟ କୋଡ୍ ପରିବର୍ତ୍ତନ ଯୋଗୁ ଜେନେରାଲାଇଜ୍ଡ୍ ଏପିଲେପ୍ସି ଓ ଇନଫଣ୍ଟାଇଲ୍ ସିଜର ସିନ୍ଡୋମ୍ ରୋଗ ହୁଏ<ref name="JClinInvestigation2005-Miriam">{{cite journal | author=Miriam H. Meisler and Jennifer A. Kearney | title=Sodium channel mutations in epilepsy and other neurological disorders | journal=Journal of Clinical Investigation | volume=115 | issue=8 | year=2005 | pages=2010–2017 | pmid=16075041 | doi=10.1172/JCI25466 | pmc=1180547}}</ref> । <br />
== ଆଧାର ==
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