ବାଇସୋପ୍ରୋଲୋଲ

ବାଇସୋପ୍ରୋଲୋଲ
Clinical data
Trade names	Zebeta, Concor, others
AHFS/Drugs.com	monograph
MedlinePlus	a693024
data	US FDA: Bisoprolol;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	by mouth
ATC code	C07AB07 (WHO) ;
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Bioavailability	>90%
Protein binding	30%
Metabolism	50% liver, CYP2D6, CYP3A4
Elimination half-life	10–12 hours
Identifiers
	IUPAC name (RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-; 3-(isopropylamino)propan-2-ol;
CAS Number	66722-44-9 ;
PubChem CID	2405;
IUPHAR/BPS	7129;
DrugBank	DB00612 ;
ChemSpider	2312 ;
UNII	Y41JS2NL6U;
KEGG	D02342 ;
ChEBI	CHEBI:3127 ;
ChEMBL	CHEMBL645 ;
ECHA InfoCard	100.108.941
Chemical and physical data
Formula	C18H31NO4
Molar mass	325.443 g/mol
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES O(c1ccc(cc1)COCCOC(C)C)CC(O)CNC(C)C;
	InChI InChI=1S/C18H31NO4/c1-14(2)19-11-17(20)13-23-18-7-5-16(6-8-18)12-21-9-10-22-15(3)4/h5-8,14-15,17,19-20H,9-13H2,1-4H3 ; Key:VHYCDWMUTMEGQY-UHFFFAOYSA-N ;
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ବାଇସୋପ୍ରୋଲୋଲ (ଇଂରାଜୀ ଭାଷାରେ Bisoprolol, ବେପାର ନାମ ଜେବାଟା/Zebeta) ଏକ ଔଷଧ ଯାହା ହୃତ୍‌ପିଣ୍ଡ ରୋଗମାନଙ୍କରେ (heart disease) ଦିଆଯାଏ ।^[୪] ଉଚ୍ଚ ରକ୍ତଚାପ (high blood pressure), ଆଞ୍ଜିନା ପେକ୍ଟୋରିସ (chest pain from not enough blood flow to the heart) ଓ ହୃଦ୍‌ପାତ ଇତ୍ୟାଦି ରୋଗମାନଙ୍କରେ ଦିଆଯାଏ ।^[୪]^[୫] ପାଟିରେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୪]

ବାଇସୋପ୍ରୋଲୋଲର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବଥା, ଥକ୍କା ଅନୁଭବ, ତରଳ ଝାଡ଼ା ଓ ପ୍ରାନ୍ତୀୟ ଇଡିମା/ଶୋଥ (swelling in the legs) ଇତ୍ୟାଦି ଲକ୍ଷଣ ଦେଖାଯାଏ ।^[୪] ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟାରେ ଆଜ୍‌ମା ରୋଗ ବୃଦ୍ଧିପ୍ରାପ୍ତ ହୁଏ, ଅଳ୍ପ ରକ୍ତ ଶର୍କରା ଚିହ୍ନିବା ଶକ୍ତି ଅବରୋଧ ହୁଏ ଓ ହୃଦ୍‌ପାତ ଖରାପ ଦିଗକୁ ଗତି କରେ ।^[୬] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବ‌ହାର କଲେ ଶିଶୁ ପ୍ରତି ବିପଦ ଥାଏ ।^[୭] ଏହା ବିଟା ବ୍ଲକର ( Beta blocker) ଶ୍ରେଣୀର ଏକ ଔଷଧ ଓ ବିଟା_୧ (β₁ selective) ସିଲେକ୍ଟିଭ ଟାଇପର ଔଷଧ ।^[୪]

ବାଇସୋପ୍ରୋଲୋଲ ସନ ୧୯୭୬ରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଓ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସନ ୧୯୭୬ରେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୮] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ (World Health Organization's List of Essential Medicines) ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ (health system) ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୯] ଏହା ଜେନେରିକ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୪] ବିକାଶଶୀଳ ଦେଶମାନଙ୍କରେ (developing world) ଏହି ଔଷଧର ଏକ ମାସର ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୨.୯୮ରୁ ୪.୯୪ ଆମେରିକୀୟ ଡଲାର ।^[୧୦] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ଏକ ମାସ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୨୫ରୁ ୫୦ ଆମେରିକୀୟ ଡଲାର ।^[୧୧]

ଆଧାର

↑ Yuji Horikiri; Takehiko Suzuki; Masakazu Mizobe (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences. 87 (3): 289–294. doi:10.1021/js970316d.
↑ Bühring KU, Sailer H, Faro HP, Leopold G, Pabst J, Garbe A (1986). "Pharmacokinetics and metabolism of bisoprolol-14C in three animal species and in humans". J. Cardiovasc. Pharmacol. 8 Suppl 11: S21–8. doi:10.1097/00005344-198511001-00004. PMID 2439794.
↑ Leopold G (1986). "Balanced pharmacokinetics and metabolism of bisoprolol". J. Cardiovasc. Pharmacol. 8 Suppl 11: S16–20. doi:10.1097/00005344-198511001-00003. PMID 2439789.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Bisoprolol Fumarate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.
↑ "Bisoprolol 2.5mg/5mg/10mg film coated tablet - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 18 February 2014. Archived from the original on 20 December 2016. Retrieved 14 December 2016.
↑ "Bisoprolol - FDA prescribing information, side effects and uses". www.drugs.com. Retrieved 14 December 2016.
↑ "Bisoprolol (Zebeta) Use During Pregnancy". www.drugs.com. Retrieved 14 December 2016.
↑ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 461. ISBN 9783527607495.
↑ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.
↑ "Bisoprolol". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 151. ISBN 9781284057560.

[1] Yuji Horikiri; Takehiko Suzuki; Masakazu Mizobe (March 1998). "Pharmacokinetics and metabolism of bisoprolol enantiomers in humans". Journal of Pharmaceutical Sciences. 87 (3): 289–294. doi:10.1021/js970316d.

[pmid2439794-2] Bühring KU, Sailer H, Faro HP, Leopold G, Pabst J, Garbe A (1986). "Pharmacokinetics and metabolism of bisoprolol-14C in three animal species and in humans". J. Cardiovasc. Pharmacol. 8 Suppl 11: S21–8. doi:10.1097/00005344-198511001-00004. PMID 2439794.

[pmid2439789-3] Leopold G (1986). "Balanced pharmacokinetics and metabolism of bisoprolol". J. Cardiovasc. Pharmacol. 8 Suppl 11: S16–20. doi:10.1097/00005344-198511001-00003. PMID 2439789.

[AHFS2016-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Bisoprolol Fumarate". The American Society of Health-System Pharmacists. Retrieved 8 December 2016.

[5] "Bisoprolol 2.5mg/5mg/10mg film coated tablet - Summary of Product Characteristics (SPC) - (eMC)". www.medicines.org.uk. 18 February 2014. Archived from the original on 20 December 2016. Retrieved 14 December 2016.

[Pro2016-6] "Bisoprolol - FDA prescribing information, side effects and uses". www.drugs.com. Retrieved 14 December 2016.

[7] "Bisoprolol (Zebeta) Use During Pregnancy". www.drugs.com. Retrieved 14 December 2016.

[Fis2006-8] Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 461. ISBN 9783527607495.

[WHO19th-9] "WHO Model List of Essential Medicines (19th List)" (PDF). World Health Organization. April 2015. Retrieved 8 December 2016.

[ERC2014-10] "Bisoprolol". International Drug Price Indicator Guide. Retrieved 8 December 2016.^{[permanent dead link]}

[Ric2015-11] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 151. ISBN 9781284057560.

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