ଟେରିପାରାଟାଇଡ

ଟେରିପାରାଟାଇଡ
Clinical data
Trade names	Forteo, Forsteo, Teribone, Bonsity
AHFS/Drugs.com	monograph
MedlinePlus	a603018
data	EU EMA: yes; US DailyMed: Teriparatide;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	Subcutaneous
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx only ;
Pharmacokinetic data
Bioavailability	95%
Metabolism	Liver (nonspecific proteolysis)
Elimination half-life	Subcutaneous: 1 hour
Excretion	Kidney (metabolites)
Identifiers
ECHA InfoCard	100.168.733
Chemical and physical data
Formula	C181H291N55O51S2
Molar mass	୪,୧୧୭.୭୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [H]/N=C(\N)/NCCC[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2c1cccc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN/C(=N/[H])/N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc4ccccc4)C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc5cnc[nH]5)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc6cnc[nH]6)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CO)N;
	InChI InChI=1S/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)/t96-,103-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,143-,144-,145-,146-/m0/s1 ; Key:OGBMKVWORPGQRR-UMXFMPSGSA-N ;
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ଟେରିପାରାଟାଇଡ, ଏକ ବେପାର ନାମ ଫୋର୍ଟିଓ, ହେଉଛି ଓଷ୍ଟିଓପୋରୋସିସ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ପାରାଥାଇରଏଡ଼ ହରମୋନ (PTH) ।^[୨] ଯେଉଁମାନଙ୍କର ବାଇଫୋସଫୋନେଟ କାମ କରେ ନାହିଁ କିମ୍ବା ଅତ୍ୟଧିକ ବିପଦ ଥିଲେ ଏହା ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୨] ଏହା ଚର୍ମ ତଳେ ଇଞ୍ଜେକସନଦ୍ୱାରା ଦିଆଯାଏ | ^[୨] ଏହା ଦୁଇ ବର୍ଷ ପର୍ଯ୍ୟନ୍ତ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯନ୍ତ୍ରଣା, ଅଇ, ରାସ, ଅବସାଦ ଏବଂ ଦାନ୍ତ ସମସ୍ୟା ହୋଇପାରେ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଓଷ୍ଟିଓସ୍କାର୍କୋମା, ଆନାଫାଇଲକସିସ, ଛିଡା ହେବା ସହିତ ନିମ୍ନ ରକ୍ତଚାପ ହେବାର ଆଶଙ୍କା ରହିପାରେ ।^[୨] ଏହା ପିଟିଏଚର ସକ୍ରିୟ ଅଂଶକୁ ନେଇ ଗଠିତ ଏବଂ ହାଡ ଗଠନକୁ ପ୍ରୋତ୍ସାହିତ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୨] ^[୪]

୨୦୦୨ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୦୩ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଟେରିପାରାଟାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨]^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏକ ମାସର ଖର୍ଚ୍ଚ ପ୍ରାୟ ୨୪୦ ପାଉଣ୍ଡ ହୋଇଥାଏ ।^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୩,୯୦୦ ଡଲାର ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Teriparatide Use During Pregnancy". Drugs.com. 25 November 2019. Archived from the original on 27 October 2020. Retrieved 14 September 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Teriparatide". drugs.com. American Society of Health-System Pharmacists. Archived from the original on 29 June 2021. Retrieved 1 October 2021.
↑ ^୩.୦ ^୩.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 774. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୪.୦ ^୪.୧ "Forsteo EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 27 June 2020. Retrieved 26 June 2020.
↑ "Forteo". Goodrx.com. Archived from the original on 11 November 2016. Retrieved 1 October 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Teriparatide Use During Pregnancy". Drugs.com. 25 November 2019. Archived from the original on 27 October 2020. Retrieved 14 September 2020.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ "Teriparatide". drugs.com. American Society of Health-System Pharmacists. Archived from the original on 29 June 2021. Retrieved 1 October 2021.

[BNF80-3] ୩.୦ ^୩.୧ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 774. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[EPAR2021-4] ୪.୦ ^୪.୧ "Forsteo EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 27 June 2020. Retrieved 26 June 2020.

[GX2021-5] "Forteo". Goodrx.com. Archived from the original on 11 November 2016. Retrieved 1 October 2021.

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