ଉଇକିପିଡ଼ିଆ

ଇନୋଟର୍ସେନ

ଏହା ବଂଶାନୁକ୍ରମିକ ଟ୍ରାନସଥାଇରେଟିନ-ମଧ୍ୟସ୍ଥ ଆମିଲଏଡୋସିସ୍ (HATTR) ରୋଗରେ ହେଉଥିବା ସ୍ନାୟୁ କ୍ଷତିର ଚିକିତ୍ସା

ଇନୋଟର୍ସେନ (ଇଂରାଜୀ ଭାଷାରେ Inotersen), ଟେଗସେଡି ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ବଂଶାନୁକ୍ରମିକ ଟ୍ରାନସଥାଇରେଟିନ-ମଧ୍ୟସ୍ଥ ଆମିଲଏଡୋସିସ୍ (HATTR) ରୋଗରେ ହେଉଥିବା ସ୍ନାୟୁ କ୍ଷତିର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।[୪] ଏହା ସେହି ଲୋକମାନଙ୍କରେ ବ୍ୟବହୃତ ହୁଏ ଯେଉଁମାନେ ଏପର୍ଯ୍ୟନ୍ତ ଚାଲିବାରେ ସକ୍ଷମ ଅଟନ୍ତି | [୫] ଚର୍ମ ତଳେ ଇଞ୍ଜେକସନ ଆକାରରେ ଏହା ଦିଆଯାଏ ।[୪]

ଇନୋଟର୍ସେନ
Clinical data
Trade namesTegsedi
SynonymsGSK-2998728, ISIS-420915
AHFS/Drugs.commonograph
data
Pregnancy
category
  • US: N (Not classified yet)
Routes of
administration		Subcutaneous injection
Legal status
Legal status
Chemical and physical data
FormulaC230H318N69O121P19S19
Molar mass୭,୧୮୩.୦୮ g·mol−1
3D model (JSmol)
  • CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=S)(O)OC3CC(OC3COP(=S)(O)OC4CC(OC4COP(=S)(O)OC5C(OC(C5OCCOC)N6C=NC7=C6N=C(NC7=O)N)COP(=S)(O)OC8C(OC(C8OCCOC)N9C=C(C(=O)NC9=O)C)COP(=S)(O)OC1C(OC(C1OCCOC)N1C=C(C(=O)NC1=O)C)COP(=O)(OC1C(OC(C1OCCOC)N1C=C(C(=NC1=O)N)C)COP(=S)(O)OC1C(OC(C1OCCOC)N1C=C(C(=O)NC1=O)C)CO)S)N1C=NC2=C1N=C(NC2=O)N)N1C=C(C(=O)NC1=O)C)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(CC(O1)N1C=C(C(=NC1=O)N)C)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(CC(O1)N1C=C(C(=O)NC1=O)C)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C1N=C(NC2=O)N)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(CC(O1)N1C=NC2=C(N=CN=C21)N)OP(=S)(O)OCC1C(C(C(O1)N1C=NC2=C(N=CN=C21)N)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=O)NC1=O)C)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=NC1=O)N)C)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=NC1=O)N)C)OCCOC)OP(=S)(O)OCC1C(C(C(O1)N1C=C(C(=NC1=O)N)C)OCCOC)O
  • InChI=1S/C230H318N69O121P19S19/c1-98-53-280(219(312)262-178(98)231)140-43-110(121(382-140)66-364-425(328,444)406-114-47-144(292-90-254-150-183(236)244-85-249-188(150)292)387-126(114)71-368-423(326,442)404-112-45-142(282-59-104(7)197(303)274-225(282)318)383-122(112)67-363-421(324,440)403-111-44-141(281-58-103(6)196(302)273-224(281)317)385-124(111)69-366-427(330,446)410-119-52-149(297-95-260-156-194(297)268-217(242)271-204(156)310)391-130(119)75-372-431(334,450)419-167-139(401-215(177(167)362-42-32-352-22)299-97-261-157-195(299)269-218(243)272-205(157)311)84-381-438(341,457)418-165-136(398-213(175(165)360-40-30-350-20)291-64-109(12)202(308)279-230(291)323)82-379-437(340,456)417-163-135(397-211(173(163)358-38-28-348-18)289-62-107(10)200(306)277-228(289)321)81-378-435(338,454)414-161-132(394-209(171(161)356-36-26-346-16)286-56-101(4)181(234)265-222(286)315)78-375-433(336,452)412-159-120(65-300)392-207(169(159)354-34-24-344-14)288-61-106(9)199(305)276-227(288)320)402-422(325,441)367-70-125-115(48-145(386-125)293-91-255-151-184(237)245-86-250-189(151)293)407-426(329,445)365-68-123-113(46-143(384-123)283-60-105(8)198(304)275-226(283)319)405-424(327,443)371-74-129-118(51-148(390-129)296-94-259-155-193(296)267-216(241)270-203(155)309)409-429(332,448)370-72-127-116(49-146(388-127)294-92-256-152-185(238)246-87-251-190(152)294)408-428(331,447)369-73-128-117(50-147(389-128)295-93-257-153-186(239)247-88-252-191(153)295)411-430(333,449)374-77-138-166(176(361-41-31-351-21)214(400-138)298-96-258-154-187(240)248-89-253-192(154)298)420-439(342,458)380-83-137-164(174(359-39-29-349-19)212(399-137)290-63-108(11)201(307)278-229(290)322)416-436(339,455)377-80-134-162(172(357-37-27-347-17)210(396-134)287-57-102(5)182(235)266-223(287)316)415-434(337,453)376-79-133-160(170(355-35-25-345-15)208(395-133)285-55-100(3)180(233)264-221(285)314)413-432(335,451)373-76-131-158(301)168(353-33-23-343-13)206(393-131)284-54-99(2)179(232)263-220(284)313/h53-64,85-97,110-149,158-177,206-215,300-301H,23-52,65-84H2,1-22H3,(H,324,440)(H,325,441)(H,326,442)(H,327,443)(H,328,444)(H,329,445)(H,330,446)(H,331,447)(H,332,448)(H,333,449)(H,334,450)(H,335,451)(H,336,452)(H,337,453)(H,338,454)(H,339,455)(H,340,456)(H,341,457)(H,342,458)(H2,231,262,312)(H2,232,263,313)(H2,233,264,314)(H2,234,265,315)(H2,235,266,316)(H2,236,244,249)(H2,237,245,250)(H2,238,246,251)(H2,239,247,252)(H2,240,248,253)(H,273,302,317)(H,274,303,318)(H,275,304,319)(H,276,305,320)(H,277,306,321)(H,278,307,322)(H,279,308,323)(H3,241,267,270,309)(H3,242,268,271,310)(H3,243,269,272,311)/t110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120+,121+,122+,123+,124+,125+,126+,127+,128+,129+,130+,131+,132+,133+,134+,135+,136+,137+,138+,139+,140+,141+,142+,143+,144+,145+,146+,147+,148+,149+,158+,159+,160+,161+,162+,163+,164+,165+,166+,167+,168+,169+,170+,171+,172+,173+,174+,175+,176+,177+,206+,207+,208+,209+,210+,211+,212+,213+,214+,215+,421?,422?,423?,424?,425?,426?,427?,428?,429?,430?,431?,432?,433?,434?,435?,436?,437?,438?,439?/m0/s1
  • Key:KLEGMTRDCCDFJK-XDQSQZFTSA-N

ଇଞ୍ଜେକସନ ନେଇଥିବା ସ୍ଥାନରେ ଲାଲ ରଙ୍ଗ ଓ ଯନ୍ତ୍ରଣା, ଅଇ, ମୁଣ୍ଡବିନ୍ଧା, ଥକାପଣ, କମ୍ ପ୍ଲାଟୈଲେଟ ଏବଂ ଜ୍ୱର ସ୍ଥାନରେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ଲାଲତା ଏବଂ ଯନ୍ତ୍ରଣା ହୋଇପାରେ । ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବୃକ୍‌କ ପ୍ରଦାହ, ଷ୍ଟ୍ରୋକ, ଜୀବସାର କ ଅଭାବ, ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ ।[୬] [୪] ଏହା ଏକ ଆଣ୍ଟିସେନ୍ସ ଓଲିଗୋନିଉକ୍ଲିଓଟାଇଡ ଅଟେ ।[୪]

୨୦୧୮ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ଚିକିତ୍ସାରେ ବ୍ୟବହାର ପାଇଁ ଇନୋଟର୍ସେନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୪] [୫] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହାର ଚିକିତ୍ସା ପିଛା ବାର୍ଷିକ ୩୩୨,୦୦୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।[୭] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୫୨୧,୦୦୦ ଡଲାର ଥିବାବେଳେ କାନାଡ଼ାରେ ଏହା ପ୍ରାୟ ୪୨୦,୦୦୦ କାନାଡ଼ା ଡଲାର ଅଟେ ।[୮] [୯]

ଆଧାର

ସମ୍ପାଦନା
  1. ↑ ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; Tegsedi EPAR ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।
  2. ↑ "Tegsedi 284 mg solution for injection in pre-filled syringe - Summary of Product Characteristics (SmPC)". (emc). 15 October 2019. Archived from the original on 7 October 2020. Retrieved 3 October 2020.
  3. ↑ "Tegsedi- inotersen injection, solution". DailyMed. 2 September 2020. Archived from the original on 7 October 2020. Retrieved 3 October 2020.
  4. ↑ ୪.୦ ୪.୧ ୪.୨ ୪.୩ ୪.୪ "Inotersen Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 December 2021. Retrieved 26 November 2021.
  5. ↑ ୫.୦ ୫.୧ "Tegsedi". Archived from the original on 8 October 2020. Retrieved 26 November 2021.
  6. ↑ ଆଧାର ଭୁଲ: ଅଚଳ <ref> ଚିହ୍ନ; FDA2021 ନାମରେ ଥିବା ଆଧାର ଭିତରେ କିଛି ଲେଖା ନାହିଁ ।
  7. ↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1109. ISBN 978-0857114105.
  8. ↑ "Tegsedi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 November 2021. Retrieved 26 November 2021.
  9. ↑ "CADTH Canadian Drug Expert Committee Recommendation" (PDF). CADTH. Archived (PDF) from the original on 20 October 2020. Retrieved 26 November 2021.
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