ଭେନଲାଫାକ୍ସିନ

ଭେନଲାଫାକ୍ସିନ
Clinical data
Trade names	Effexor, others
AHFS/Drugs.com	monograph
data	US DailyMed: b23637e5-d37f-41b5-ba76-fc053e903bc2;
Pregnancy; category	AU: B2 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
ATC code	N06AX16 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	42±15%
Protein binding	27±2% (parent compound), 30±12% (active metabolite, desvenlafaxine)
Metabolism	Liver (~50% of the parent compound is metabolised on first pass through the liver)
Elimination half-life	5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended release preparations), 11±2 h (active metabolite)
Excretion	Kidney (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites)
Identifiers
	IUPAC name (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexanol;
CAS Number	93413-69-5 ;
PubChem CID	5656;
DrugBank	DB00285 ;
ChemSpider	5454 ;
UNII	GRZ5RCB1QG;
KEGG	D08670 ;
ChEBI	CHEBI:9943 ;
ChEMBL	CHEMBL637 ;
ECHA InfoCard	100.122.418
Chemical and physical data
Formula	C17H27NO2
Molar mass	277.402 g/mol
3D model (JSmol)	Interactive image;
Chirality	Racemic mixture
	SMILES OC2(C(c1ccc(OC)cc1)CN(C)C)CCCCC2;
	InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3 ; Key:PNVNVHUZROJLTJ-UHFFFAOYSA-N ;
(verify)

ଭେନଲାଫାକ୍ସିନ (ଇଂରାଜୀ ଭାଷାରେ Venlafaxine, ଏକ ବିକ୍ରୟ ନାମ ଏଫେକ୍ସର/ Effexor) ଏକ ସେରୋଟୋନିନ-ନରଏପିନେଫ୍ରିନ ରିଅପଟେକ ଇନହିବିଟର (serotonin-norepinephrine reuptake inhibitor/ SNRI) ଶ୍ରେଣୀର ଏକ ଅବସାଦରୋଧୀ ଔଷଧ ।^[୪] ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀ/ MDD), ଜେନେରାଲାଇଜଡ ଅଙ୍ଗଜାଇଟି ଡିଜଅର୍ଡ଼ର (generalized anxiety disorder/ GAD), ପ୍ୟାନିକ ଡିଜ‌ଅର୍ଡ଼ର ଓ ସୋସିଆଲ ଫୋବିଆ (social phobia) ଇତ୍ୟାଦି ରୋଗମାନଙ୍କ ଚିକିତ୍ସାରେ ଏହା ଦିଆଯାଏ ।^[୪] ପାଟିରେ ଏହି ଔଷଧ ଦିଆଯାଏ । ^[୪]

ଭେନଲାଫାକ୍ସିନର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅରୁଚି, କୋଷ୍ଠକାଠିନ୍ୟ, ଶୁଷ୍କ ପାଟି, ଓଜନିଆ ମୁଣ୍ଡ, ଝାଳ ବୋହିବା ଓ ଯୌନ ସମସ୍ୟା ଆଦି ଦେଖାଯାଏ ।^[୪] ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ସାଂଘାତିକ ହେଲେ ଆତ୍ମହତ୍ୟା ସଙ୍କଟ, ମାନିଆ (mania) ଓ ସେରୋଟୋନିନ ସିଣ୍ଡ୍ରୋମ ଇତ୍ୟାଦି ହୋଇପାରେ ।^[୪] ଔଷଧ ହଠାତ ବନ୍ଦ କରିଦେଲେ ଆଣ୍ଟିଡିପ୍ରେସାଣ୍ଟ ଉଇଥଡ୍ରଆଲ ସିଣ୍ଡ୍ରୋମ (Antidepressant withdrawal syndrome) ହୋଇପାରେ ।^[୪] ଗର୍ଭାବସ୍ଥାର ଶେଷ ଭାଗରେ ଏହା ଦେଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ । ^[୪] ଏହାର କାର୍ଯ୍ୟବିଧି ସ୍ପଷ୍ଟ ନହେଲେ ମଧ୍ୟ ମସ୍ତିଷ୍କର ନିଉରୋଟ୍ରାନ୍ସମିଟରରେ (neurotransmitter) ପରିବର୍ତ୍ତନ ଯୋଗୁ ହେଉଥିବା ବିଶ୍ୱାସ କରାଯାଏ ।^[୪]

ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୧୯୯୩ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଭେନଲାଫାକ୍ସିନ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୪] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ ।^[୪] ସନ ୨୦୧୮ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏକ ଡୋଜର ହୋଲସେଲ ମୂଲ୍ୟ ୦.୨୦ ଡଲାରରୁ କମ୍ ଥିଲା ।^[୫] ସନ ୨୦୧୬ରେ ଏହାର ୧୫ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିପସନ ତାଲିକାରେ ୫୧ତମ ସ୍ଥାନ ଅଧିକାର କରିଥିଲା ।^[୬]

ଆଧାର

↑ "Venlafaxine international brands". Drugs.com. Retrieved 22 June 2017.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Apo-Venlafaxine XR Capsules" (PDF). TGA eBusiness Services. Macquarie Park, NSW: Apotex Pty Ltd. 13 April 2012. Retrieved 6 November 2013.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited]". DailyMed. Aurobindo Pharma Limited. February 2013. Retrieved 6 November 2013.
↑ ^୪.୦୦ ^୪.୦୧ ^୪.୦୨ ^୪.୦୩ ^୪.୦୪ ^୪.୦୫ ^୪.୦୬ ^୪.୦୭ ^୪.୦୮ ^୪.୦୯ "Venlafaxine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Retrieved 24 December 2018.
↑ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

ବାହ୍ୟ ଲିଙ୍କ

[brands-1] "Venlafaxine international brands". Drugs.com. Retrieved 22 June 2017.

[TGA-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Apo-Venlafaxine XR Capsules" (PDF). TGA eBusiness Services. Macquarie Park, NSW: Apotex Pty Ltd. 13 April 2012. Retrieved 6 November 2013.

[DM-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Venlafaxine (venlafaxine hydrochloride) tablet [Aurobindo Pharma Limited]". DailyMed. Aurobindo Pharma Limited. February 2013. Retrieved 6 November 2013.

[AHFS2018-4] ୪.୦୦ ^୪.୦୧ ^୪.୦୨ ^୪.୦୩ ^୪.୦୪ ^୪.୦୫ ^୪.୦୬ ^୪.୦୭ ^୪.୦୮ ^୪.୦୯ "Venlafaxine Hydrochloride Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). AHFS. Retrieved 24 December 2018.

[5] "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.

[6] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

[୪]

[୧]

[୨]

[୩]

[୫]

[୬]

Clinical data


Trade names	Effexor, others ^[୧]
AHFS/Drugs.com	monograph
data	US DailyMed: b23637e5-d37f-41b5-ba76-fc053e903bc2
Pregnancy category	AU: B2 US: C (Risk not ruled out)
Routes of administration	By mouth
ATC code	N06AX16 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) CA: ℞-only UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	42±15%^[୨]
Protein binding	27±2% (parent compound), 30±12% (active metabolite, desvenlafaxine)^[୩]
Metabolism	Liver (~50% of the parent compound is metabolised on first pass through the liver)^[୨]^[୩]
Elimination half-life	5±2 h (parent compound for immediate release preparations), 15±6 h (parent compound for extended release preparations), 11±2 h (active metabolite)^[୨]^[୩]
Excretion	Kidney (87%; 5% as unchanged drug; 29% as desvenlafaxine and 53% as other metabolites)^[୨]^[୩]
Identifiers
IUPAC name (RS)-1-[2-dimethylamino-1-(4-methoxyphenyl)-ethyl]cyclohexanol
CAS Number	93413-69-5^Y
PubChem CID	5656
DrugBank	DB00285^Y
ChemSpider	5454^Y
UNII	GRZ5RCB1QG
KEGG	D08670^Y
ChEBI	CHEBI:9943^Y
ChEMBL	CHEMBL637^Y
ECHA InfoCard	100.122.418
Chemical and physical data
Formula	C₁₇H₂₇NO₂
Molar mass	277.402 g/mol
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES OC2(C(c1ccc(OC)cc1)CN(C)C)CCCCC2
InChI InChI=1S/C17H27NO2/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14/h7-10,16,19H,4-6,11-13H2,1-3H3^Y Key:PNVNVHUZROJLTJ-UHFFFAOYSA-N^Y
(verify)