ଟାଇଗେସାଇକ୍ଲିନ

ଟାଇଗେସାଇକ୍ଲିନ
Clinical data
Pronunciation	/ˌtaɪɡəˈsaɪkliːn/
Trade names	Tygacil
AHFS/Drugs.com	monograph
MedlinePlus	a614002
data	EU EMA: yes; US DailyMed: Tigecycline;
Pregnancy; category	AU: D ; US: D (Evidence of risk) ; ;
Routes of; administration	Intravenous (IV)
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Protein binding	71–89%
Metabolism	Not metabolized
Elimination half-life	42.4 hours
Excretion	59% Bile, 33% kidney
Identifiers
	IUPAC name N-[(5aR,6aS,7S,9Z,10aS)-9-(amino-hydroxy-methylidene)-4,7-bis(dimethylamino)-1,10a,12-trihydroxy-8,10,11-trioxo-5a,6,6a,7-tetrahydro-5H-tetracen-2-yl]-2-(tert-butylamino) acetamide;
ECHA InfoCard	100.211.439
Chemical and physical data
Formula	C29H39N5O8
Molar mass	୫୮୫.୬୬ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)NCC(=O)Nc1cc(c2C[C@H]3C[C@H]4[C@H](N(C)C)C(\O)=C(\C(N)=O)C(=O)[C@@]4(O)C(/O)=C3/C(=O)c2c1O)N(C)C;
	InChI InChI=1S/C29H39N5O8/c1-28(2,3)31-11-17(35)32-15-10-16(33(4)5)13-8-12-9-14-21(34(6)7)24(38)20(27(30)41)26(40)29(14,42)25(39)18(12)23(37)19(13)22(15)36/h10,12,14,21,31,36,38-39,42H,8-9,11H2,1-7H3,(H2,30,41)(H,32,35)/t12-,14-,21-,29-/m0/s1 ; Key:FPZLLRFZJZRHSY-HJYUBDRYSA-N ;
(verify)

ଟାଇଗେସାଇକ୍ଲିନ, ଏକ ବେପାର ନାମ ଟାଇଗାସିଲ, ହେଉଛି ଏକ ଟେଟ୍ରାସାଇକ୍ଲିନ୍ ଆଣ୍ଟିବାୟୋଟିକ୍ ଯାହା ଅନେକ ଜୀବାଣୁ ସଂକ୍ରମଣ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ଏଥିରେ ଉଦର ସଂକ୍ରମଣ, ନିମୋନିଆ ଏବଂ ଚର୍ମ ଅଂଶର ସଂକ୍ରମଣ ହୋଇପାରେ ।^[୫] ଏହା କମ୍ ପ୍ରଭାବଶାଳୀ ହୋଇଥିବାର ଅନ୍ୟାନ୍ୟ ଆଣ୍ଟିବାୟୋଟିକ ଅନୁପଯୁକ୍ତ ହେଲେ ଏହା ବ୍ୟବହାର କରିବାକୁ ।^[୨] ^[୫] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ ଏବଂ ତରଳ ଝାଡ଼ା ହୋଇପାରେ ।^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆତପଦାହ, ଅଗ୍ନାଶୟ ପ୍ରଦାହ, ଯକୃତ ସମସ୍ୟା, କ୍ଲୋଷ୍ଟ୍ରିଡିଓଡେସ ଡିଫିସିଲ ସଂକ୍ରମଣ ଏବଂ ଆନାଫାଇଲକ୍‌ସିସ ହୋଇପାରେ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁମାନଙ୍କର ହାଡ଼ କିମ୍ବା ଦାନ୍ତକୁ ନଷ୍ଟ କରିପାରେ ।^[୫] ^[୬] ଏହା ଏକ ଗ୍ଲାଇସିସାଇକ୍ଲିନ୍ ଏବଂ ବ୍ୟାକ୍ଟେରିଆର ରାଇବୋସୋମକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୫] ^[୨]

ଆମେରିକାରେ ୨୦୦୫ ମସିହାରେ ଏବଂ ୟୁରୋପରେ ୨୦୦୬ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ପାଇଁ ଟାଇଗେସାଇକ୍ଲିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୭]^[୨] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନ ଏହାକୁ ମାନବ ଚିକିତ୍ସା ପାଇଁ ଗୁରୁତ୍ୱପୂର୍ଣ୍ଣ ଶ୍ରେଣୀଭୁକ୍ତ କରିଛି ।^[୮]^[୯] ^[୧୦] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୬] ୨୦୨୧ ସୁଦ୍ଧା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ପାଞ୍ଚ ଦିନର ଚିକିତ୍ସା ଖର୍ଚ୍ଚ ପ୍ରାୟ ୮୦୦ ଡଲାର ଥିଲା ।^[୧୧] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶି ନିମନ୍ତେ ୨୯୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Tigecycline (Tygacil) Use During Pregnancy". Drugs.com. 6 July 2020. Archived from the original on 28 November 2020. Retrieved 26 September 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Tygacil EPAR". European Medicines Agency (EMA) (in ଆର୍ଗୋନୀ). Archived from the original on 12 November 2020. Retrieved 26 September 2020.
↑ "Tygacil- tigecycline injection, powder, lyophilized, for solution". DailyMed. 20 July 2020. Archived from the original on 23 March 2021. Retrieved 26 September 2020.
↑ "EP2181330". European Patent Office. Archived from the original on 9 August 2020. Retrieved 29 September 2017.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ "Tigecycline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 August 2021. Retrieved 4 October 2021.
↑ ^୬.୦ ^୬.୧ ^୬.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 601. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Tigecycline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 August 2021. Retrieved 4 October 2021.
↑ World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.
↑ World Health Organization (2019). The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl:10665/330668. ISBN 9789241210300. ISSN 0512-3054. WHO technical report series;1021.
↑ World Health Organization (2019). Critically important antimicrobials for human medicine (6th revision ed.). Geneva: World Health Organization. hdl:10665/312266. ISBN 9789241515528.
↑ "Tigecycline Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 November 2020. Retrieved 4 October 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ "Tigecycline (Tygacil) Use During Pregnancy". Drugs.com. 6 July 2020. Archived from the original on 28 November 2020. Retrieved 26 September 2020.

[Tygacil_EPAR-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Tygacil EPAR". European Medicines Agency (EMA) (in ଆର୍ଗୋନୀ). Archived from the original on 12 November 2020. Retrieved 26 September 2020.

[Tygacil_FDA_label-3] "Tygacil- tigecycline injection, powder, lyophilized, for solution". DailyMed. 20 July 2020. Archived from the original on 23 March 2021. Retrieved 26 September 2020.

[4] "EP2181330". European Patent Office. Archived from the original on 9 August 2020. Retrieved 29 September 2017.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ "Tigecycline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 August 2021. Retrieved 4 October 2021.

[BNF80-6] ୬.୦ ^୬.୧ ^୬.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 601. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHSF2021-7] "Tigecycline Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 August 2021. Retrieved 4 October 2021.

[WHO21st-8] World Health Organization (2019). Executive summary: the selection and use of essential medicines 2019: report of the 22nd WHO Expert Committee on the selection and use of essential medicines. Geneva: World Health Organization. hdl:10665/325773. WHO/MVP/EMP/IAU/2019.05. License: CC BY-NC-SA 3.0 IGO.

[9] World Health Organization (2019). The selection and use of essential medicines: report of the WHO Expert Committee on Selection and Use of Essential Medicines, 2019 (including the 21st WHO Model List of Essential Medicines and the 7th WHO Model List of Essential Medicines for Children). Geneva: World Health Organization. hdl:10665/330668. ISBN 9789241210300. ISSN 0512-3054. WHO technical report series;1021.

[10] World Health Organization (2019). Critically important antimicrobials for human medicine (6th revision ed.). Geneva: World Health Organization. hdl:10665/312266. ISBN 9789241515528.

[11] "Tigecycline Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 12 November 2020. Retrieved 4 October 2021.

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