ମିସୋପ୍ରୋସ୍ଟଲ

ମିସୋପ୍ରୋସ୍ଟଲ
Clinical data
Trade names	Cytotec, Misodel, other
AHFS/Drugs.com	monograph
MedlinePlus	a689009
Pregnancy; category	AU: X (High risk) ; US: X (Contraindicated) ; ;
Routes of; administration	By mouth, vaginal, under the tongue
ATC code	A02BB01 (WHO) G02AD06;
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	extensively absorbed
Protein binding	80-90% (active metabolite, misoprostol acid)
Metabolism	Liver (extensive to misoprostic acid)
Elimination half-life	20–40 minutes
Excretion	Urine (80%)
Identifiers
	IUPAC name Methyl 7-((1R,2R,3R)-3-hydroxy-2-((S,E)-4-hydroxy-4-methyloct-1-enyl)-5-oxocyclopentyl)heptanoate;
CAS Number	59122-46-2 ;
PubChem CID	5282381;
IUPHAR/BPS	1936;
DrugBank	DB00929 ;
ChemSpider	4445541 ;
UNII	0E43V0BB57;
KEGG	D00419 ;
ChEMBL	CHEMBL606 ;
ECHA InfoCard	100.190.521
Chemical and physical data
Formula	C22H38O5
Molar mass	382.534 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C1C[C@@H](O)[C@H](/C=C/CC(O)(C)CCCC)[C@H]1CCCCCCC(=O)OC;
	InChI InChI=1S/C22H38O5/c1-4-5-14-22(2,26)15-10-12-18-17(19(23)16-20(18)24)11-8-6-7-9-13-21(25)27-3/h10,12,17-18,20,24,26H,4-9,11,13-16H2,1-3H3/b12-10+/t17-,18-,20-,22?/m1/s1 ; Key:OJLOPKGSLYJEMD-URPKTTJQSA-N ;
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ମିସୋପ୍ରୋସ୍ଟଲ, ବିକ୍ରୟ ନାମ ସାଇଟୋଟେକ, ଗୋଟିଏ ଔଷଧ ଯାହା ପ୍ରସବ ପ୍ରାରମ୍ଭ, ଗର୍ଭପାତ, ଦୁର୍ବଳ ଜରାୟୁ ସଙ୍କୋଚନ ଜନିତ ପ୍ରସବୋତ୍ତର ରକ୍ତସ୍ରାବ ନିମନ୍ତେ ଓ ପେପ୍‌ଟିକ ଅଲସରର ଚିକିତ୍ସା ତ‌ଥା ପ୍ରତିଷେଧ ନିମନ୍ତେ ଦିଆଯାଏ । ^[୧] ଗର୍ଭପାତ ନିମନ୍ତେ ଏହା ସ‌ହିତ ମିଫେପ୍ରିସ୍ଟୋନ ବା ମେଥୋଟ୍ରେକ୍‌ସେଟ ଦିଆଯାଏ ।^[୨]ଏହାକୁ ଏକ‌କ ଭାବରେ ଦେଲେ ୬୬%ରୁ ୯୦% ଫଳପ୍ରଦ ହୁଏ । ^[୩]ଏହା ପାଟିରେ, ଜିଭ ତଳେ ଓ ଯୋନୀ ମଧ୍ୟରେ ଦିଆଯାଇପାରେ ।^[୨]^[୪]

ଏହାର ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ମଧ୍ୟରେ ତରଳ ଝାଡ଼ା ଓ ପେଟ ଯନ୍ତ୍ରଣା ଉଲ୍ଲେଖନୀୟ । ଏହାକୁ ଗର୍ଭାବସ୍ଥା ଶ୍ରେଣୀ X ରଖାଯାଇଛି କାରଣ ଗର୍ଭାବସ୍ଥାରେ ଏହା ଦେଲେ ଶିଶୁର ଅସୁବିଧା ହେବା ଜଣାଯାଇଛି । ଜରାୟୁ ମଧ୍ୟ ଫାଟିଯାଇପାରେ । ଏହା ଏକ ପ୍ରୋସ୍ଟାଗ୍ଲାଣ୍ଡିନ ଆନାଲଗ—ବିଶେଷତଃ ଏକ କୃତ୍ରିମ ପ୍ରୋସ୍ଟାଗ୍ଲାଣ୍ଡିନ ଇ_୧ (PGE₁).^[୧]

ମିସୋପ୍ରୋସ୍ଟଲ ସନ ୧୯୭୩ରେ ପ୍ରସ୍ତୁତ କରାଯାଇଥିଲା ।^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ମୌଳିକ ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ । ^[୬] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ।^[୧] ଡୋଜ ପିଛା ଏହାର ହୋଲସେଲ ମୂଲ୍ୟ ୦.୩୬ରୁ ୨.୦୦ ଆମେରିକୀୟ ଡଲାର ।^[୭] ପାକସ୍ଥଳୀ ଘାଆ ରୋଗ ଥିଲେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଗୋଟିଏ ମାସ ଔଷଧ ଯୋଗାଣର ମୂଲ୍ୟ ୧୦୦ରୁ ୨୦୦ ଡଲାର ।^[୮]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ "Misoprostol". The American Society of Health-System Pharmacists. Retrieved Feb 20, 2015.
↑ ^୨.୦ ^୨.୧ Kulier, R; Kapp, N; Gülmezoglu, AM; Hofmeyr, GJ; Cheng, L; Campana, A (9 November 2011). "Medical methods for first trimester abortion". The Cochrane database of systematic reviews (11): CD002855. PMID 22071804.
↑ Bryant, AG; Regan, E; Stuart, G (January 2014). "An overview of medical abortion for clinical practice". Obstetrical & gynecological survey. 69 (1): 39–45. PMID 25102250.
↑ Marret, H; Simon, E; Beucher, G; Dreyfus, M; Gaudineau, A; Vayssière, C; Lesavre, M; Pluchon, M; Winer, N; Fernandez, H; Aubert, J; Bejan-Angoulvant, T; Jonville-Bera, AP; Clouqueur, E; Houfflin-Debarge, V; Garrigue, A; Pierre, F; Collège national des gynécologues obstétriciens, français (April 2015). "Overview and expert assessment of off-label use of misoprostol in obstetrics and gynaecology: review and report by the Collège national des gynécologues obstétriciens français". European journal of obstetrics, gynecology, and reproductive biology. 187: 80–4. PMID 25701235.
↑ Paul, Maureen (2011). "Misoprostol". Management of Unintended and Abnormal Pregnancy: Comprehensive Abortion Care. John Wiley & Sons. ISBN 9781444358476.
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ "Misoprostol". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 20 December 2015.
↑ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 271. ISBN 9781284057560.

[AHFS2015-1] ୧.୦ ^୧.୧ ^୧.୨ "Misoprostol". The American Society of Health-System Pharmacists. Retrieved Feb 20, 2015.

[Kap2011-2] ୨.୦ ^୨.୧ Kulier, R; Kapp, N; Gülmezoglu, AM; Hofmeyr, GJ; Cheng, L; Campana, A (9 November 2011). "Medical methods for first trimester abortion". The Cochrane database of systematic reviews (11): CD002855. PMID 22071804.

[3] Bryant, AG; Regan, E; Stuart, G (January 2014). "An overview of medical abortion for clinical practice". Obstetrical & gynecological survey. 69 (1): 39–45. PMID 25102250.

[4] Marret, H; Simon, E; Beucher, G; Dreyfus, M; Gaudineau, A; Vayssière, C; Lesavre, M; Pluchon, M; Winer, N; Fernandez, H; Aubert, J; Bejan-Angoulvant, T; Jonville-Bera, AP; Clouqueur, E; Houfflin-Debarge, V; Garrigue, A; Pierre, F; Collège national des gynécologues obstétriciens, français (April 2015). "Overview and expert assessment of off-label use of misoprostol in obstetrics and gynaecology: review and report by the Collège national des gynécologues obstétriciens français". European journal of obstetrics, gynecology, and reproductive biology. 187: 80–4. PMID 25701235.

[5] Paul, Maureen (2011). "Misoprostol". Management of Unintended and Abnormal Pregnancy: Comprehensive Abortion Care. John Wiley & Sons. ISBN 9781444358476.

[6] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[7] "Misoprostol". International Drug Price Indicator Guide. Archived from the original on 10 May 2017. Retrieved 20 December 2015.

[Ric2015-8] Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 271. ISBN 9781284057560.

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