ହାଇଡ୍ରକ୍ସିଜିନ

ହାଇଡ୍ରକ୍ସିଜିନ
Clinical data
Pronunciation	/haɪˈdrɒksɪziːn/
Trade names	Atarax, Vistaril, others
Synonyms	UCB-4492
AHFS/Drugs.com	monograph
MedlinePlus	a682866
Pregnancy; category	AU: A ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth, intramuscular injection
ATC code	N05BB01 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only) ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	High
Protein binding	93%
Metabolism	Hepatic
Metabolites	Cetirizine, others
Elimination half-life	Adults: 20.0 hours; Children: 7.1 hours
Excretion	Urine, feces
Identifiers
	IUPAC name (±)-2-(2-{4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl}ethoxy)ethanol;
CAS Number	68-88-2 ;
PubChem CID	3658;
IUPHAR/BPS	7199;
DrugBank	DB00557 ;
ChemSpider	3531 ;
UNII	30S50YM8OG;
KEGG	D08054 ;
ChEBI	CHEBI:5818 ;
ChEMBL	CHEMBL896 ;
ECHA InfoCard	100.000.630
Chemical and physical data
Formula	C21H27ClN2O2
Molar mass	374.904 g/mol
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCOCCO;
	InChI InChI=1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 ; Key:ZQDWXGKKHFNSQK-UHFFFAOYSA-N ;
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ହାଇଡ୍ରକ୍ସିଜିନ (ଇଂରାଜୀ ଭାଷାରେ Hydroxyzine, ଏକ ବିକ୍ରୟ ନାମ ଆଟାରାକ୍ସ/ Atarax) ଏକ ପ୍ରକାର ଆଣ୍ଟିହିସ୍ଟାମିନ (antihistamine) ଟାଇପର ଔଷଧ ।^[୩] ଉଦ୍‌ବେଗ, ଅଇ (nausea) ଓ ଗଲୁ (itchiness) ହେଉଥିଲେ ଏହି ଔଷଧ ଦିଆଯାଏ ।^[୩] ଏହି ଔଷଧ ପାଟିରେ (by mouth) ବା ମାଂସପେଶୀରେ (injection into a muscle) ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ । ^[୩]

ଏହି ଔଷଧର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ, ମୁଣ୍ଡ ବିନ୍ଧା ଓ ଶୁଷ୍କ ପାଟି (dry mouth) ହୋଇଯାଏ ।^[୩]^[୪] ସାଂଘାତିକ ପ୍ରତିକ୍ରିୟା ହେଲେ ଇସିଜିରେ କ୍ୟୁଟି ଲମ୍ବ ହୋଇଯାଏ (QT prolongation) ।^[୪] ଗର୍ଭାବସ୍ଥା ଓ ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହି ଔଷଧର ନିରାପତ୍ତା ବିଷୟ ସ୍ପଷ୍ଟ ହୋଇନାହିଁ ।^[୩] ହିସ୍ଟାମିନ (histamine) ପ୍ରଭାବକୁ ଅବରୋଧ କରି ଏହା କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୪] ପିପେରାଜିନ (piperazine) ରାସାୟନିକ ଦ୍ରବ୍ୟମାନଙ୍କ ପରିବାରର ଏହା ଏକ ସଦସ୍ୟ । ^[୩]

ସନ ୧୯୫୬ରେ ୟୁନିଅନ ସିମିକ ବେଲଗେ (en:Union Chimique Belge) ପ୍ରଥମେ ହାଇଡ୍ରକ୍ସିଜିନ ଔଷଧ ସିନଥେସିସ (made) ବା ପ୍ରସ୍ତୁତ କରିବା ପରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକା ଏହାକୁ ସେହି ବର୍ଷ ଫାଇଜର (Pfizer) କମ୍ପାନୀଦ୍ୱାରା ବିକ୍ରୟ ନିମନ୍ତେ ସ୍ୱୀକୃତି ଦେଇଥିଲେ ।^[୩]^[୫] ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ ୨୮ ମାତ୍ରାର ଔଷଧର ୧ ପାଉଣ୍ଡରୁ କମ ମୂଲ୍ୟରେ ବିକ୍ରୟ ହୁଏ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୨୦୧୮ରେ ଏହାର ଏକ ଡୋଜର ହୋଲସେଲ ମୁଲ୍ୟ ପ୍ରାୟ ୦.୦୫ ଆମେରିକୀୟ ଡଲାର ଥିଲା ।^[୬] ସନ ୨୦୧୬ରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ଏହାର ୮ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ଥିଲା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ Paton DM, Webster DR (1985). "Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)". Clin Pharmacokinet. 10 (6): 477–97. doi:10.2165/00003088-198510060-00002. PMID 2866055.
↑ Simons FE, Simons KJ, Frith EM (January 1984). "The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine". The Journal of Allergy and Clinical Immunology. 73 (1 Pt 1): 69–75. doi:10.1016/0091-6749(84)90486-x. PMID 6141198.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 November 2018.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.
↑ Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.
↑ "NADAC as of 2018-11-21". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-06-01. Retrieved 21 November 2018.
↑ "The Top 300 of 2019". clincalc.com (in ଇଂରାଜୀ). Retrieved 21 November 2018.

ବାହ୍ୟ ଲିଙ୍କ

RxList; et al. (2004). "Atarax Indications, Dosage, Storage, Stability". RxList - The internet drug index. Retrieved 2007-03-09.
Medscape (2004). "Vistaril Oral: Monograph - Hydroxyzine Hydrochloride, Hydroxyzine Pamoate". medscape.com. Retrieved 2007-03-09.
U.S. National Library of Medicine: Drug Information Portal - Hydroxyzine

[pmid2866055-1] ୧.୦ ^୧.୧ Paton DM, Webster DR (1985). "Clinical pharmacokinetics of H1-receptor antagonists (the antihistamines)". Clin Pharmacokinet. 10 (6): 477–97. doi:10.2165/00003088-198510060-00002. PMID 2866055.

[pmid6141198-2] Simons FE, Simons KJ, Frith EM (January 1984). "The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine". The Journal of Allergy and Clinical Immunology. 73 (1 Pt 1): 69–75. doi:10.1016/0091-6749(84)90486-x. PMID 6141198.

[AHSF2018-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ "Hydroxyzine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 21 November 2018.

[BNF74-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. p. X. ISBN 978-0857112989.

[Shor2009-5] Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.

[6] "NADAC as of 2018-11-21". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2019-06-01. Retrieved 21 November 2018.

[7] "The Top 300 of 2019". clincalc.com (in ଇଂରାଜୀ). Retrieved 21 November 2018.

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