ଫ୍ଲୁଟିକାସୋନ ପ୍ରୋପିଓନେଟ

ଫ୍ଲୁଟିକାସୋନ ପ୍ରୋପିଓନେଟ
Clinical data
Trade names	Flovent, Flixotide (inhaled); Flixonase, Flonase (nasal)
AHFS/Drugs.com	monograph
data	EU EMA: yes;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	Intranasal, inhaled, topical
ATC code	D07AC17 (WHO) & D07AC04 (topical);
Legal status
Legal status	UK: Pharmacy medicines ; US: OTC ;
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91%
Metabolism	Intranasal; Liver (CYP3A4-mediated)
Elimination half-life	10 hours
Excretion	Kidney
Identifiers
	IUPAC name S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate;
CAS Number	80474-14-2 ;
PubChem CID	444036;
IUPHAR/BPS	7080;
DrugBank	DB00588 ;
ChemSpider	392059 ;
UNII	O2GMZ0LF5W;
ChEBI	CHEBI:31441 ;
ChEMBL	CHEMBL1473 ;
ECHA InfoCard	100.129.097
Chemical and physical data
Formula	C25H31F3O5S
Molar mass	500.57 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(SCF)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1 ; Key:WMWTYOKRWGGJOA-CENSZEJFSA-N ;
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ଫ୍ଲୁଟିକାସୋନ ପ୍ରୋପିଓନେଟ (ଇଂରାଜୀ ଭାଷାରେ Fluticasone propionate) ବିକ୍ରୟ ନାମ ଫ୍ଲୋଭେଣ୍ଟ/ Flovent ଓ ଫ୍ଲୋନେଜ/ Flonase) ଏକ ପ୍ରକାର ସ୍ଟିରଏଡ (steroid) ଇଞ୍ଜେକସନ ।^[୧] ଆଜ୍‌ମା ଓ ସିଓପିଡି ରୋଗର ଦୀର୍ଘକାଳୀନ ଆଘ୍ରାଣ ଚିକିତ୍ସା ନିମନ୍ତେ ଏହା ଦିଆଯାଏ ।^[୧] ହେଫିଭର (hay fever) ଓ ନାଜାଲ ପଲିପ (nasal polyps) ରୋଗର ଚିକିତ୍ସା ନିମନ୍ତେ ନାକରେ ବ୍ୟବ‌ହାର କରାଯାଏ ।^[୨]^[୩]

ଉର୍ଦ୍ଧ୍ୱ ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ (upper respiratory tract infections), ସାଇନୁସାଇଟିସ, କାଣ୍ଡିଡିଆସିସ (thrush) ଓ କାଶ (cough) ରୋଗ ନିମନ୍ତେ ଏହି ଔଷଧ ଆଘ୍ରାଣ କରାଯାଏ ।^[୧] ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନାକ ରକ୍ତସ୍ରାବ (en:nosebleeding) ଓ ତଣ୍ଟି ଦରଜ ହୋଇପାରେ । ^[୨] ଏହି ଔଷଧ ପ୍ରଦାହକୁ (inflammation) କମେଇଦିଏ ।^[୧]

ସନ ୧୯୮୦ରେ ଫ୍ଲୁଟିକାସୋନ ପ୍ରୋପିଓନେଟ ପେଟେଣ୍ଟ ହେବା ପରେ ସନ ୧୯୯୦ରେ ଡାକ୍ତରୀ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।^[୪] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ (generic medication) ବିକ୍ରୟ ହୁଏ । ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ର ଆମେରିକାରେ ସନ ୨୦୧୮ରେ ଏହି ଔଷଧ ବାବଦ ଏକ ସ୍ପ୍ରେ ବାବଦରେ ୦.୩୩ ଆମେରିକୀୟ ଡଲାର ଖର୍ଚ୍ଚ ହୁଏ । ^[୫] ସନ ୨୦୧୯ରେ ସଂଯୁକ୍ତ ରାଷ୍ଟ୍ରରେ (United Kingdom) ଏନଏଚଏସକୁ (NHS) ଏହାର ଏକ ସ୍ପ୍ରେ ପିଛା ପ୍ରାୟ ୦.୧୩ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା ।^[୩] ସନ ୨୦୧୬ରେ ଏହି ଔଷଧ ୨୯ ନିୟୁତ ପ୍ରେସକ୍ରିପସନ ହୋଇ ସର୍ବାଧିକ ପ୍ରେସକ୍ରିପସନ ତାଲିକାରେ ୧୬ ତମ ସ୍ଥାନରେ ଥିଲା ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Fluticasone Propionate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 February 2019.
↑ ^୨.୦ ^୨.୧ "Fluticasone Propionate eent Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 February 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 262, 1172. ISBN 9780857113382.
↑ Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 487. ISBN 9783527607495.
↑ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.
↑ "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

[AHFS2019Inhaled-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Fluticasone Propionate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 February 2019.

[AHFS2019ENT-2] ୨.୦ ^୨.୧ "Fluticasone Propionate eent Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). American Society of Health-System Pharmacists. Retrieved 27 February 2019.

[BNF76-3] ୩.୦ ^୩.୧ ^୩.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 262, 1172. ISBN 9780857113382.

[4] Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 487. ISBN 9783527607495.

[5] "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services (in ଇଂରାଜୀ). Archived from the original on 2018-12-19. Retrieved 22 December 2018.

[6] "The Top 300 of 2019". clincalc.com. Retrieved 22 December 2018.

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Clinical data

Trade names	Flovent, Flixotide (inhaled) Flixonase, Flonase (nasal)
AHFS/Drugs.com	monograph
data	EU EMA: yes
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Intranasal, inhaled, topical
ATC code	D07AC17 (WHO) & D07AC04 (topical)
Legal status
Legal status	UK: Pharmacy medicines US: OTC
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91%
Metabolism	Intranasal Liver (CYP3A4-mediated)
Elimination half-life	10 hours
Excretion	Kidney
Identifiers
IUPAC name S-(fluoromethyl)-6α,9-difluoro-11β, 17-dihydroxy-16α-methyl-3-oxoandrosta-1, 4-diene-17β-carbothioate, 17-propanoate
CAS Number	80474-14-2^Y
PubChem CID	444036
IUPHAR/BPS	7080
DrugBank	DB00588^Y
ChemSpider	392059^Y
UNII	O2GMZ0LF5W
ChEBI	CHEBI:31441^Y
ChEMBL	CHEMBL1473^Y
ECHA InfoCard	100.129.097
Chemical and physical data
Formula	C₂₅H₃₁F₃O₅S
Molar mass	500.57 g/mol
3D model (JSmol)	Interactive image
SMILES O=C(SCF)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
InChI InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1^Y Key:WMWTYOKRWGGJOA-CENSZEJFSA-N^Y
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