ଡ୍ରକ୍ସିଡୋପା

ଡ୍ରକ୍ସିଡୋପା
Clinical data
Pronunciation	drox" i doe' pa
Trade names	Northera
Synonyms	β,3-Dihydroxytyrosine, L-DOPS,L-threo-dihydroxyphenylserine, L-threo-DOPS, SM-5688
AHFS/Drugs.com	monograph
MedlinePlus	a614025
data	US DailyMed: Droxidopa;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	90%
Metabolism	Liver
Elimination half-life	1.5 hours
Excretion	Kidney
Identifiers
	IUPAC name (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid;
ECHA InfoCard	100.215.254
Chemical and physical data
Formula	C9H11NO5
Molar mass	୨୧୩.୧୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O;
	InChI InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1; Key:QXWYKJLNLSIPIN-JGVFFNPUSA-Na;
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ଡ୍ରକ୍ସିଡୋପା (ଇଂରାଜୀ ଭାଷାରେ Droxidopa), ନର୍ଥେରା ଏହାର ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଛିଡା ହେବା ସହିତ ନିମ୍ନ ରକ୍ତଚାପ ହେବାର ସ୍ନାୟୁଗତ କାରଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହି କାରଣଗୁଡ଼ିକ ମଧ୍ୟରେ ପାର୍କିନ୍‌ସନ୍ ରୋଗ, ସ୍ୱୟଂଶାସିତ ନ୍ୟୁରୋପାଥି ଏବଂ ଏକାଧିକ ସିଷ୍ଟମିକ୍ ଆଟ୍ରୋଫି ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୧] ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ମୁଣ୍ଡ ବୁଲାଇବା, ଅଇ, ଏବଂ ଉଚ୍ଚ ରକ୍ତଚାପ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଉରୋଲେପ୍ଟିକ ମାଲିଗନାଣ୍ଟ ସିଣ୍ଡ୍ରୋମ କିମ୍ବା ହୃଦ୍‌ପାତ ହୋଇପାରେ ।^[୧] ^[୨] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୨] ଏହା ଶରୀରରେ ନର୍‌ଏପିନେଫ୍ରିନ (ନରଆଡ୍ରେନାଲିନ୍)ରେ ପରିଣତ ହେବା ପରେ କାମ କରେ ।^[୧]

୨୦୧୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଡ୍ରକ୍ସିଡୋପା ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ୟୁରୋପ କିମ୍ବା ବ୍ରିଟେନରେ ଏହା ଅନୁମୋଦିତ ନୁହେଁ ।^[୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ଦିନକୁ ୩୦୦ ମିଗ୍ରା ମାତ୍ରାରେ ଏକ ମାସ ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୭୪୦ ଡଲାର ଅଟେ ।^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Droxidopa". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 27 December 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Droxidopa Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 September 2020. Retrieved 27 December 2021.
↑ "Droxidopa". SPS - Specialist Pharmacy Service. 5 January 2016. Archived from the original on 11 January 2022. Retrieved 27 December 2021.
↑ ^୪.୦ ^୪.୧ "Droxidopa Prices and Droxidopa Coupons - GoodRx". GoodRx. Archived from the original on 8 May 2016. Retrieved 27 December 2021.

[Liv2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Droxidopa". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 15 May 2021. Retrieved 27 December 2021.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Droxidopa Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 September 2020. Retrieved 27 December 2021.

[3] "Droxidopa". SPS - Specialist Pharmacy Service. 5 January 2016. Archived from the original on 11 January 2022. Retrieved 27 December 2021.

[GX2021-4] ୪.୦ ^୪.୧ "Droxidopa Prices and Droxidopa Coupons - GoodRx". GoodRx. Archived from the original on 8 May 2016. Retrieved 27 December 2021.

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Clinical data

Pronunciation	drox" i doe' pa^[୧]
Trade names	Northera
Synonyms	β,3-Dihydroxytyrosine, L-DOPS,L-threo-dihydroxyphenylserine, L-threo-DOPS, SM-5688
AHFS/Drugs.com	monograph
MedlinePlus	a614025
data	US DailyMed: Droxidopa
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	By mouth
Legal status
Legal status	US: ℞-only ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	90%
Metabolism	Liver
Elimination half-life	1.5 hours
Excretion	Kidney
Identifiers
IUPAC name (2S,3R)-2-Amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
ECHA InfoCard	100.215.254
Chemical and physical data
Formula	C₉H₁₁NO₅
Molar mass	୨୧୩.୧୯ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O
InChI InChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1 Key:QXWYKJLNLSIPIN-JGVFFNPUSA-Na
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