ଆସେଟିଲସିସ୍ଟିନ

ଆସେଟିଲସିସ୍ଟିନ (ଆଇଏନଏନ)
Clinical data
Pronunciation	/əˌsɛtəlˈsɪstiːn/
Trade names	Acetadote, Fluimucil, Mucomyst, Parvolex
AHFS/Drugs.com	monograph
data	US DailyMed: 5558a5f5-e821-473b-7d8a-5d33d09f0586;
Pregnancy; category	AU: B2 ; US: B (No risk in non-human studies) ; ;
Routes of; administration	Oral, injection, inhalation
ATC code	R05CB01 (WHO) S01XA08 V03AB23;
Legal status
Legal status	AU: S2 (Pharmacy only) ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	10% (Oral)
Protein binding	50 to 83%
Metabolism	Liver
Elimination half-life	5.6 hours
Excretion	Renal (30%), faecal (3%)
Identifiers
	IUPAC name (2R)-2-acetamido-3-sulfanylpropanoic acid;
CAS Number	616-91-1 ;
PubChem CID	581;
DrugBank	DB06151 ;
ChemSpider	561 ;
UNII	WYQ7N0BPYC;
KEGG	D00221 ;
ChEBI	CHEBI:28939 ;
ChEMBL	CHEMBL600 ;
ECHA InfoCard	100.009.545
Chemical and physical data
Formula	C5H9NO3S
Molar mass	163.195
3D model (JSmol)	Interactive image;
Melting point	106 °C (223 °F)
Boiling point	108 °C (226 °F)
Solubility in water	200 mg/mL (20 °C)
	SMILES CC(=O)NC(CS)C(O)=O;
	InChI InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9) ; Key:PWKSKIMOESPYIA-UHFFFAOYSA-N ;
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ଆସେଟିଲସିସ୍ଟିନ, ଅନ୍ୟ ନାମ ଏନ-ଆସେଟିଲସିସ୍ଟିନ ବାr ଏନ-ଆସେଟିଲ-ଏଲ-ସିସ୍ଟିନ (ଏନଏସି), ଏକ ଔଷଧ ଯାହା ପାରାସେଟାମୋଲ(ଆସେଟାମିନୋଫେନ) ଅଧିକମାତ୍ରା (overdose) ନିମନ୍ତେ ଦିଆଯାଏ ଓ ସିସ୍ଟିକ ଫାଇବ୍ରୋସିସ ତ‌ଥା କ୍ରନିକ ଅବସ୍ଟ୍ରକ୍ଟିଭ ପଲମୋନାରି ଡିଜିଜ ରୋଗମାନଙ୍କରେ ବ‌ହଳିଆ ଖଙ୍କାର ପତଳା କରିବା ପାଇଁ ଦିଆଯାଏ । ^[୧] ଏହି ଔଷଧ ପାଟିରେ ଖାଇବାକୁ, ଶୀରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଓ ଆଘ୍ରଣକାରୀ ଆକାରରେ ଦିଆଯାଏ ।^[୧]

ଔଷଧ ଖାଇଲେ ଅଇ ଓ ବାନ୍ତି ହୋଇପାରେ । ବେଳେବେଳେ ଚର୍ମ ଲାଲ ଦେଖାଯାଏ ଓ ଗଲୁ କରେ । ଆନାଫାଇଲାକ୍‌ସିସ ମଧ୍ୟ ହୋଇପାରେ । ଗର୍ଭାବସ୍ଥାରେ ଏହା ବିପଦମୁକ୍ତ ରହେ । ଏହାର କର୍ଯ୍ୟପ୍ରଣାଳୀ: ଗ୍ଲୁଟାଥାୟନ ସ୍ତର ବୃଦ୍ଧି କରେ ଓ ପରାସେଟାମୋଲର ବିଷାକ୍ତ ରାସାୟନିକ ବିଭାଜିତ ଦ୍ରବ୍ୟଗୁଡ଼ିକ ସ‌ହିତ ଯୋଡ଼ିହୋଇଯାଏ ।^[୧]

ଆସେଟିଲସିସ୍ଟିନ ସନ ୧୯୬୦ରେ ପେଟେଣ୍ଟ କରାଯାଇଥିଲା ଓ ସନ ୧୯୬୮ରେ ବ୍ୟବ‌ହାର ନିମନ୍ତେ ଲାଇସେନ୍ସ ଦିଆଯାଇଥିଲା । ^[୫] ଏହାର ନାମ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଅଛି ଯାହା ସ୍ୱାସ୍ଥ୍ୟ ସିସ୍ଟମ ନିମନ୍ତେ ଅତି ମହତ୍ତ୍ୱପୂର୍ଣ୍ଣ ।^[୬] ଏହା ଜେନେରିକ ଔଷଧ ନାମରେ ଉପଲବ୍‌ଧ ହୁଏ ଓ ଦାମିକା ନୁହେଁ । ^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Acetylcysteine". The American Society of Health-System Pharmacists. Retrieved Aug 22, 2015.
↑ Stockley, Robert A. (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management. Chichester: John Wiley & Sons. p. 750. ISBN 9780470755280. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ "ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]". DailyMed. Cumberland Pharmaceuticals Inc. June 2013. Retrieved 8 November 2013.
↑ "L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 9 January 2012.
↑ Fischer, János; Ganellin, C. Robin (2006). Analogue-Based Drug Discovery. Weinheim: Wiley-VCH. p. 544. ISBN 9783527607495. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
↑ "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
↑ Baker, Emma (2014). Top 100 drugs : clinical pharmacology and practical prescribing. p. Acetylcysteine. ISBN 9780702055157. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[AHFS2015-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ "Acetylcysteine". The American Society of Health-System Pharmacists. Retrieved Aug 22, 2015.

[2] Stockley, Robert A. (2008). Chronic Obstructive Pulmonary Disease a Practical Guide to Management. Chichester: John Wiley & Sons. p. 750. ISBN 9780470755280. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[DMI-3] "ACETADOTE (acetylcysteine) injection, solution [Cumberland Pharmaceuticals Inc.]". DailyMed. Cumberland Pharmaceuticals Inc. June 2013. Retrieved 8 November 2013.

[4] "L-Cysteine, N-acetyl- - Compound Summary". PubChem Compound. USA: National Center for Biotechnology Information. 25 March 2005. Identification. Retrieved 9 January 2012.

[5] Fischer, János; Ganellin, C. Robin (2006). Analogue-Based Drug Discovery. Weinheim: Wiley-VCH. p. 544. ISBN 9783527607495. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

[6] "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.

[7] Baker, Emma (2014). Top 100 drugs : clinical pharmacology and practical prescribing. p. Acetylcysteine. ISBN 9780702055157. {{cite book}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

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