ସେଲିନେକ୍ସର

ସେଲିନେକ୍ସର
Clinical data
Trade names	Xpovio, Nexpovio
Synonyms	KPT-330
AHFS/Drugs.com	monograph
MedlinePlus	a619044
data	US DailyMed: Selinexor;
Pregnancy; category	Use should be avoided;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Protein binding	95%
Metabolism	Liver oxidation, glucuronidation, and conjugation, by CYP3A4, UGT and GST
Elimination half-life	6–8 hours
Identifiers
	IUPAC name (2Z)-3-{3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl}-N′-pyrazin-2-ylprop-2-enehydrazide;
Chemical and physical data
Formula	C17H11F6N7O
Molar mass	୪୪୩.୩୧ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CN=C(C=N1)NNC(=O)/C=C\N2C=NC(=N2)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F;

ସେଲିନେକ୍ସର (ଇଂରାଜୀ ଭାଷାରେ Selinexor) ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ୍ସପୋଭିଓ (Xpovio) ଏକ ବେପାର ନାମ, ହେଉଛି ମଲ୍ଟିପ୍ଲ ମାୟେଲୋମା ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୩] ଅତିକମରେ ୪ ପ୍ରକାର ଚିକିତ୍ସା ଫଳପ୍ରଦ ହୋଇ ନ ଥିବା କ୍ଷେତ୍ରରେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହାକୁ ଡେକ୍ସାମେଥାଜୋନ ସହିତ ପାଟିରେ ଦିଆଯାଏ ।^[୩] ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାନ୍ତି, ଓଜନ ହ୍ରାସ, ତରଳ ଝାଡ଼ା, ଥକ୍କା, କମ୍ ରକ୍ତ ପ୍ଲାଟେଲେଟ ବା ଥ୍ରୋମ୍ବୋସାଇଟୋପେନିଆ, ସ୍ୱଳ୍ପ ଲାଲ ରକ୍ତ କଣିକା, ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା ଏବଂ ଅଳ୍ପ ସୋଡ଼ିଅମ ରକ୍ତ‌ତା ହୋଇପାରେ । ^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସିଙ୍କୋପ୍ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୩] ଏହା ପରମାଣୁ ରପ୍ତାନୀର ପ୍ରତିବନ୍ଧକ ଏବଂ ଏକ୍ସପୋର୍ଟିନ୧କୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୧]

୨୦୧୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୧ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ସେଲିନକ୍ସର ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଚିକିତ୍ସାରେ ପ୍ରତି ୪ ସପ୍ତାହରେ ପ୍ରାୟ ୨୪,୦୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଅନୁମୋଦିତ ହୋଇଥିଲେ ମଧ୍ୟ ଏହା ୨୦୨୧ ସୁଦ୍ଧା ଉପଲବ୍ଧ ହୋଇ ନଥିଲା ।^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Nexpovio EPAR". European Medicines Agency (EMA). 25 January 2021. Archived from the original on 2 June 2021. Retrieved 27 May 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ "Xpovio- selinexor tablet, film coated". DailyMed. 19 August 2019. Archived from the original on 29 August 2021. Retrieved 20 November 2019.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Selinexor Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 August 2020. Retrieved 12 October 2021.
↑ "Xpovio Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 April 2021. Retrieved 12 October 2021.
↑ "Selinexor". SPS - Specialist Pharmacy Service. 19 June 2017. Archived from the original on 13 October 2021. Retrieved 12 October 2021.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Nexpovio EPAR". European Medicines Agency (EMA). 25 January 2021. Archived from the original on 2 June 2021. Retrieved 27 May 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[Xpovio_FDA_label-2] "Xpovio- selinexor tablet, film coated". DailyMed. 19 August 2019. Archived from the original on 29 August 2021. Retrieved 20 November 2019.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Selinexor Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 14 August 2020. Retrieved 12 October 2021.

[4] "Xpovio Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 April 2021. Retrieved 12 October 2021.

[SP2021-5] "Selinexor". SPS - Specialist Pharmacy Service. 19 June 2017. Archived from the original on 13 October 2021. Retrieved 12 October 2021.

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