ସେଟମେଲାନୋଟାଇଡ

ସେଟମେଲାନୋଟାଇଡ
Clinical data
Trade names	Imcivree
Synonyms	RM-493; BIM-22493; IRC-022493; N2-Acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-cysteinamide, cyclic (2-8)-disulfide
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Setmelanotide;
Routes of; administration	Subcutaneous
Legal status
Legal status	US: ℞-only ; EU: Rx-only ;
Identifiers
	IUPAC name (4R,7S,10S,13R,16S,19R,22R)-22-[[(2S)-2-Acetamido-5-(diaminomethylideneamino)pentanoyl]amino]-13-benzyl-10-[3-(diaminomethylideneamino)propyl]-16-(1H-imidazol-5-ylmethyl)-7-(1H-indol-3-ylmethyl)-19-methyl-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexazacyclotricosane-4-carboxamide;
Chemical and physical data
Formula	C49H68N18O9S2
Molar mass	୧,୧୧୭.୩୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)C)C(=O)N)Cc2c[nH]c3c2cccc3)CCCN=C(N)N)Cc4ccccc4)Cc5cnc[nH]5;
	InChI InChI=1S/C49H68N18O9S2/c1-26-41(70)63-37(20-30-22-55-25-59-30)46(75)64-35(18-28-10-4-3-5-11-28)44(73)62-34(15-9-17-57-49(53)54)43(72)65-36(19-29-21-58-32-13-7-6-12-31(29)32)45(74)66-38(40(50)69)23-77-78-24-39(47(76)60-26)67-42(71)33(61-27(2)68)14-8-16-56-48(51)52/h3-7,10-13,21-22,25-26,33-39,58H,8-9,14-20,23-24H2,1-2H3,(H2,50,69)(H,55,59)(H,60,76)(H,61,68)(H,62,73)(H,63,70)(H,64,75)(H,65,72)(H,66,74)(H,67,71)(H4,51,52,56)(H4,53,54,57)/t26-,33+,34+,35-,36+,37+,38+,39+/m1/s1; Key:HDHDTKMUACZDAA-PHNIDTBTSA-N;

ସେଟମେଲାନୋଟାଇଡ (ଇଂରାଜୀ ଭାଷାରେ Setmelanotide), ଇମସିଭ୍ରି ବେପାର ନାମରେ ବିକ୍ରି ହୁଏ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୋଟାପଣର ନିର୍ଦ୍ଦିଷ୍ଟ ଜେନେଟିକ କାରଣଗୁଡିକର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ^[୧] ଏଥିରେ ମହତ୍ୱପୂର୍ଣ୍ଣ ପ୍ରୋ-ଓପିଓମେଲାନୋକର୍ଟିନ୍ (POMC) ଅଭାବ, ପ୍ରୋପ୍ରୋଟିନ୍ କନଭର୍ଟେଜ୍ ସବଟିଲିସିନ/କେକ୍ସିନ ପ୍ରକାର 1 (PCSK1) ଅଭାବ, ଲେପ୍ଟିନ୍ ରିସେପ୍ଟର (LEPR) ଅଭାବ ଏବଂ ବାର୍ଡେଟ-ବିଡଲ ସିଣ୍ଡ୍ରୋମ (BBS) ହୋଇପାରେ ।^[୨] ଅତିକମରେ ୬ ବର୍ଷ ବୟସରେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଚର୍ମ ତଳେ ଇଞ୍ଜେକସନ ଆକାରରେ ଏହା ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଇଞ୍ଜେକସନ ନେଇଥିବା ସ୍ଥାନରେ ପ୍ରତିକ୍ରିୟା, ବର୍ଦ୍ଧିତ ଚର୍ମ ସୁକ୍ଷ୍ମ ବର୍ଣ୍ଣକଣିକା ବା ପିଗମେଣ୍ଟେସନ୍, ମୁଣ୍ଡବିନ୍ଧା, ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ପେଟ ଯନ୍ତ୍ରଣା ଏବଂ ଅବସାଦ ହୋଇପାରେ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯୌନ ଉତ୍ପୀଡ଼ନ ଏବଂ ଆତ୍ମହତ୍ୟା ଚିନ୍ତାଧାରା ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ କିମ୍ବା ସ୍ତନ୍ୟପାନ ସମୟରେ ଏହି ଔଷଧ ଦେବାକୁ ପରାମର୍ଶ ଦିଆଯାଇନଥାଏ ।^[୨] ଏହା ଏକ ମେଲାନୋକର୍ଟିନ ୪ (MC4) ରିସେପ୍ଟର ଆଗୋନିଷ୍ଟ ।^[୨]

୨୦୨୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୧ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ସେଟମେଲାନୋଟାଇଡ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୨ ସୁଦ୍ଧା ଏହି ଚିକିତ୍ସା ବାବଦ ମାସକୁ ପ୍ରାୟ ୩୩,୦୦୦ ଡଲାର ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Imcivree EPAR". European Medicines Agency (EMA). 19 May 2021. Archived from the original on 23 July 2021. Retrieved 22 July 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ ^୨.୮ "Imcivree- setmelanotide solution". DailyMed. Archived from the original on 21 October 2021. Retrieved 25 December 2020.
↑ "FDA approves first treatment for weight management for people with certain rare genetic conditions". U.S. Food and Drug Administration (FDA) (Press release). 27 November 2020. Archived from the original on 27 November 2020. Retrieved 27 November 2020. This article incorporates text from this source, which is in the public domain.
↑ "Imcivree". Archived from the original on 11 November 2022. Retrieved 3 November 2022.

[EPAR2022-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Imcivree EPAR". European Medicines Agency (EMA). 19 May 2021. Archived from the original on 23 July 2021. Retrieved 22 July 2021. Text was copied from this source which is © European Medicines Agency. Reproduction is authorized provided the source is acknowledged.

[PI2022-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ ^୨.୮ "Imcivree- setmelanotide solution". DailyMed. Archived from the original on 21 October 2021. Retrieved 25 December 2020.

[FDA_PR-3] "FDA approves first treatment for weight management for people with certain rare genetic conditions". U.S. Food and Drug Administration (FDA) (Press release). 27 November 2020. Archived from the original on 27 November 2020. Retrieved 27 November 2020. This article incorporates text from this source, which is in the public domain.

[4] "Imcivree". Archived from the original on 11 November 2022. Retrieved 3 November 2022.

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