ଲେମ୍ବୋରେକ୍ସାଣ୍ଟ

ଲେମ୍ବୋରେକ୍ସାଣ୍ଟ
Clinical data
Trade names	Dayvigo
Synonyms	E-2006
AHFS/Drugs.com	monograph
data	US DailyMed: Lemborexant;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: Schedule IV ;
Pharmacokinetic data
Protein binding	94%
Metabolism	Liver (major: CYP3A4, minor: CYP3A5)
Metabolites	M10
Elimination half-life	17–19 hours
Excretion	Feces: 57.4%; Urine: 29.1%
Identifiers
	IUPAC name (1R,2S)-2-[(2,4-Dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl)cyclopropane-1-carboxamide;
Chemical and physical data
Formula	C22H20F2N4O2
Molar mass	୪୧୦.୪୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=NC(=NC=C1OCC2(CC2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C;
	InChI InChI=1S/C22H20F2N4O2/c1-13-19(11-25-14(2)27-13)30-12-22(15-4-3-5-16(23)8-15)9-18(22)21(29)28-20-7-6-17(24)10-26-20/h3-8,10-11,18H,9,12H2,1-2H3,(H,26,28,29)/t18-,22+/m0/s1; Key:MUGXRYIUWFITCP-PGRDOPGGSA-N;

ଲେମ୍ବୋରେକ୍ସାଣ୍ଟ, ଏକ ବେପାର ନାମ ଡେମ୍ବିଗୋ, ଏକ ଔଷଧ ଯାହା ନିଦ୍ରାହୀନତା ଯୋଗୁ ହେଉଥିବା ଅସୁବିଧା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ନିଦ ନ ହେବା ପାଇଁ ଓ ନିଦ ଆସିଯିବା ପାଇଁ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିଦ୍ରାଳୁ ଭାବ ହୋଇଯାଏ ।^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସମନ୍ୱୟ ଅଭାବ, ପକ୍ଷାଘାତ, ନିଦ୍ରା ଅବସ୍ଥାରେ ଚାଲିବା, ଅପବ୍ୟବହାର ଏବଂ ଆତ୍ମହତ୍ୟା ପ୍ରବଣ ହୋଇପାରେ ।^[୨] ^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୪] ଏହା ଏକ ଓରେକ୍ସିନ ରିସେପ୍ଟର ବ୍ଲକର ଅଟେ ।^[୨]

୨୦୧୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଲେମ୍ବୋରେକ୍ସାଣ୍ଟ ଅନୁମୋଦିତ ହୋଇଥିଲା । ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ୨୦୨୧ ସୁଦ୍ଧା ମାସକୁ ଖର୍ଚ୍ଚ ପ୍ରାୟ ୩୨୦ ଡଲାର ଥିଲା ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହା ଏକ ଅନୁସୂଚୀତ ଚତୁର୍ଥ ନିୟନ୍ତ୍ରିତ ପଦାର୍ଥ ।^[୩]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Dayvigo". Therapeutic Goods Administration (TGA). 23 July 2021. Archived from the original on 5 September 2021. Retrieved 5 September 2021.
↑ ^୨.୦୦ ^୨.୦୧ ^୨.୦୨ ^୨.୦୩ ^୨.୦୪ ^୨.୦୫ ^୨.୦୬ ^୨.୦୭ ^୨.୦୮ ^୨.୦୯ ^୨.୧୦ ^୨.୧୧ ^୨.୧୨ "Dayvigo- lemborexant tablet, film coated". DailyMed. Archived from the original on 24 June 2021. Retrieved 17 June 2021.
↑ ^୩.୦ ^୩.୧ "Lemborexant Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 September 2020. Retrieved 21 November 2021.
↑ "Lemborexant (Dayvigo) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 27 August 2021. Retrieved 21 November 2021.
↑ "Dayvigo Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 21 November 2021.

[Dayvigo_APM_summary-1] ୧.୦ ^୧.୧ "Dayvigo". Therapeutic Goods Administration (TGA). 23 July 2021. Archived from the original on 5 September 2021. Retrieved 5 September 2021.

[PI2021-2] ୨.୦୦ ^୨.୦୧ ^୨.୦୨ ^୨.୦୩ ^୨.୦୪ ^୨.୦୫ ^୨.୦୬ ^୨.୦୭ ^୨.୦୮ ^୨.୦୯ ^୨.୧୦ ^୨.୧୧ ^୨.୧୨ "Dayvigo- lemborexant tablet, film coated". DailyMed. Archived from the original on 24 June 2021. Retrieved 17 June 2021.

[AHFS2021-3] ୩.୦ ^୩.୧ "Lemborexant Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 September 2020. Retrieved 21 November 2021.

[4] "Lemborexant (Dayvigo) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 27 August 2021. Retrieved 21 November 2021.

[5] "Dayvigo Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 21 November 2021.

[୨]

[୧]

[୩]

[୪]

[୫]