ରୋଜିଗ୍ଲିଟାଜୋନ

ରୋଜିଗ୍ଲିଟାଜୋନ
Clinical data
Trade names	Avandia, others
AHFS/Drugs.com	monograph
MedlinePlus	a699023
data	EU EMA: yes; US FDA: Rosiglitazone;
Pregnancy; category	AU: B3 ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	99%
Protein binding	99.8%
Metabolism	Liver (CYP2C8-mediated)
Elimination half-life	3–4 hours
Excretion	Kidney (64%) and fecal (23%)
Identifiers
	IUPAC name (RS)-5-[4-(2-[methyl(pyridin-2-yl)amino]ethoxy)benzyl]thiazolidine-2,4-dione;
ECHA InfoCard	100.108.114
Chemical and physical data
Formula	C18H19N3O3S
Molar mass	୩୫୭.୪୩ g·mol−1
3D model (JSmol)	Interactive image;
Melting point	122 to 123 °C (252 to 253 °F)
	SMILES O=C1NC(=O)SC1Cc3ccc(OCCN(c2ncccc2)C)cc3;
	InChI InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23) ; Key:YASAKCUCGLMORW-UHFFFAOYSA-N ;
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ରୋଜିଗ୍ଲିଟାଜୋନ, ଅନ୍ୟମାନଙ୍କ ନାମରେ ବିକ୍ରି ହେଉଥିବା ଆଭାଣ୍ଡିଆ, ଟାଇପ୍-୨ ମଧୁମେହର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୧] ମେଟଫର୍ମିନ୍ ସାଧାରଣତଃ ଏହା ନିମନ୍ତେ ଏକ ପ୍ରଥମ ଧାଡ଼ି ଔଷଧ; ଖରାପ ଫଳାଫଳ ହେଉଥିଲେ ରୋଜିଗ୍ଲିଟାଜୋନ୍ ସହିତ ଦିଆଯାଏ ।^[୧] ^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧] ଏହା ମେଟଫର୍ମିନ୍ କିମ୍ବା ଗ୍ଲାଇମପିରାଇଡ୍ ସହିତ ମିଳିତ ଭାବରେ ଉପଲବ୍ଧ ହୁଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ଉପର ଶ୍ୱାସକ୍ରିୟା ସଂକ୍ରମଣ ହୋଇପାରେ ।^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦଘାତ, ଫୁଲା, ହାଡ଼ ଭଙ୍ଗା ଏବଂ ଯକୃତ ସମସ୍ୟା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୧] ହୃଦଘାତ ସମ୍ବନ୍ଧରେ ପୂର୍ବ ଚିନ୍ତାଧାରା ଥିବାବେଳେ ଏହି ଚିନ୍ତାଧାରା ପ୍ରମାଣିତ ହୋଇନାହିଁ ।^[୪] ^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ | ^[୫] ଏହା ଥିଆଜୋଲିଡାଇନଡିଓନ ଶ୍ରେଣୀର ଏକ ଔଷଧ ଏବଂ ଇନସୁଲିନ୍ ପ୍ରତି ସମ୍ବେଦନଶୀଳତା ବୃଦ୍ଧି କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ।^[୧]

ରୋଜିଗ୍ଲିଟାଜୋନ ୧୯୮୭ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ^[୧] ୨୦୦୦ରେ ୟୁରୋପରେ ବ୍ୟବହାର ପାଇଁ ଏହା ଅନୁମୋଦିତ ହୋଇଥିବାବେଳେ ସୁରକ୍ଷା ଚିନ୍ତା ଯୋଗୁଁ ୨୦୧୦ରେ ଏହାର ଅନୁମୋଦନ ସ୍ଥଗିତ ରଖାଯାଇଥିଲା ଏବଂ ୨୦୧୫ରେ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା ।^[୭] ^[୮] ^[୯] ଏହା ୨୦୧୦ରେ ଭାରତର ବଜାରରୁ^[୧୦] ଏବଂ ୨୦୧୧ରେ ନ୍ୟୁଜିଲ୍ୟାଣ୍ଡରୁ ପ୍ରତ୍ୟାହାର କରାଯାଇଥିଲା ।^[୧୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏକ ମାସର ଚିକିତ୍ସା ଖର୍ଚ୍ଚ ୨୦୨୧ ପ୍ରାୟ ୧୫୦ ଡଲାର ଥିଲା ।^[୧୨]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Rosiglitazone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 25 January 2021. Retrieved 18 October 2021.
↑ Ton, Joey (4 October 2010). "#34 Rosiglitazone – Reasonable Option or Regrettable Choice?". CFPCLearn. Archived from the original on 2 July 2023. Retrieved 18 June 2023.
↑ ^୩.୦ ^୩.୧ Research, Center for Drug Evaluation and (29 June 2021). "FDA Drug Safety Communication: FDA eliminates the Risk Evaluation and Mitigation Strategy (REMS) for rosiglitazone-containing diabetes medicines". FDA (in ଇଂରାଜୀ). Archived from the original on 30 June 2021. Retrieved 19 October 2021.
↑ Lebovitz, HE (27 November 2019). "Thiazolidinediones: the Forgotten Diabetes Medications". Current diabetes reports. 19 (12): 151. doi:10.1007/s11892-019-1270-y. PMID 31776781.
↑ "Rosiglitazone (Avandia) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 19 October 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 450. ISBN 9783527607495. Archived from the original on 2020-12-21. Retrieved 2021-07-21.
↑ "Avandia". Archived from the original on 9 April 2021. Retrieved 19 October 2021.
↑ "EMEA/H/C/000268" (PDF). Archived (PDF) from the original on 19 October 2021. Retrieved 19 October 2021.
↑ "European Medicines Agency recommends suspension of Avandia, Avandamet and Avaglim". News and Events. European Medicines Agency. 2018-09-17. Archived from the original on 2015-09-24. Retrieved 2022-03-14.
↑ "Drugs banned in India". Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Archived from the original on 2015-02-21. Retrieved 2013-09-17.
↑ "Diabetes drug withdrawn". Stuff.co.nz. NZPA. 17 February 2011. Archived from the original on 13 October 2013. Retrieved 5 November 2011.
↑ "Avandia Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 April 2021. Retrieved 19 October 2021.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ ^୧.୬ "Rosiglitazone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 25 January 2021. Retrieved 18 October 2021.

[2] Ton, Joey (4 October 2010). "#34 Rosiglitazone – Reasonable Option or Regrettable Choice?". CFPCLearn. Archived from the original on 2 July 2023. Retrieved 18 June 2023.

[FDA2021MI-3] ୩.୦ ^୩.୧ Research, Center for Drug Evaluation and (29 June 2021). "FDA Drug Safety Communication: FDA eliminates the Risk Evaluation and Mitigation Strategy (REMS) for rosiglitazone-containing diabetes medicines". FDA (in ଇଂରାଜୀ). Archived from the original on 30 June 2021. Retrieved 19 October 2021.

[4] Lebovitz, HE (27 November 2019). "Thiazolidinediones: the Forgotten Diabetes Medications". Current diabetes reports. 19 (12): 151. doi:10.1007/s11892-019-1270-y. PMID 31776781.

[5] "Rosiglitazone (Avandia) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 19 October 2021.

[6] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 450. ISBN 9783527607495. Archived from the original on 2020-12-21. Retrieved 2021-07-21.

[7] "Avandia". Archived from the original on 9 April 2021. Retrieved 19 October 2021.

[8] "EMEA/H/C/000268" (PDF). Archived (PDF) from the original on 19 October 2021. Retrieved 19 October 2021.

[Europe2010-9] "European Medicines Agency recommends suspension of Avandia, Avandamet and Avaglim". News and Events. European Medicines Agency. 2018-09-17. Archived from the original on 2015-09-24. Retrieved 2022-03-14.

[India2021-10] "Drugs banned in India". Central Drugs Standard Control Organization, Dte.GHS, Ministry of Health and Family Welfare, Government of India. Archived from the original on 2015-02-21. Retrieved 2013-09-17.

[NZ2021-11] "Diabetes drug withdrawn". Stuff.co.nz. NZPA. 17 February 2011. Archived from the original on 13 October 2013. Retrieved 5 November 2011.

[12] "Avandia Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 April 2021. Retrieved 19 October 2021.

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