ଉଇକିପିଡ଼ିଆ

ରୋକୁରୋନିୟମ

ଶ୍ୱାସନଳୀର ମାଂସପେଶୀ ଶିଥିଳ କରାଏ ।

ରୋକୁରୋନିୟମ ହେଉଛି ଏକ ଔଷଧ ଯାହା ଏଣ୍ଡୋଟ୍ରାକିଆଲ ଇନଟ୍ୟୁବେସନ ଓ ରାପିଡ ସିକ୍ୟୁଏନସ ଇଣ୍ଡକସନ (RSI) ସମୟରେ ମାଂସପେଶୀକୁ ପକ୍ଷାଘାତ କରାଏ ।[୩] [୪] ଅସ୍ତ୍ରୋପଚାର ସମୟରେ ଏବଂ ଲୋକମାନେ ଭେଣ୍ଟିଲେଟରରେ ଥିଲାବେଳେ ଏହା ମାଂସପେଶୀକୁ ଶିଥିଳ କରିବା ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ | [୫] ଏହା ଶିରାରେ ଇଞ୍ଜେକ୍ସନ ଆକାରରେ ଦିଆଯାଏ | [୫] ଗୋଟିଏ ଡୋଜ ପ୍ରାୟ ୪୫ରୁ ୧୨୦ ସେକେଣ୍ଡ ପରେ କାମ କରିବା ଆରମ୍ଭ କରେ ଏବଂ ୨୫ରୁ ୯୦ ମିନିଟ୍ ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ | [୬] [୭]

ରୋକୁରୋନିୟମ
Clinical data
Trade namesZemuron, Esmeron, others
SynonymsRocuronium bromide, [3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enyl-2,3,4,5-tetrahydropyrrol-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate
AHFS/Drugs.commonograph
Pregnancy
category
  • C
Routes of
administration		Intravenous
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
Pharmacokinetic data
BioavailabilityNA
Protein binding~30%
MetabolismSome de-acetylation
Onset of action60 secs[୧]
Elimination half-life66–80 minutes
Duration of action25 to 90 mins[୧][୨]
ExcretionUnchanged, in bile and urine
Identifiers
  • 1-((2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-17-acetoxy-3-hydroxy-10,13-dimethyl-2-morpholinohexadecahydro-1H-cyclopenta[a]phenanthren-16-yl)-1-allylpyrrolidinium bromide
ECHA InfoCard100.122.235 Edit this at Wikidata
Chemical and physical data
FormulaC32H53BrN2O4
Molar mass୬୦୯.୬୯ g·mol−1
3D model (JSmol)
  • CC(=O)O[C@H]1[C@H](C[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(C[C@@H]([C@H](C4)O)N5CCOCC5)C)C)[N+]6(CCCC6)CC=C.[Br-]
  • InChI=1S/C32H53N2O4.BrH/c1-5-14-34(15-6-7-16-34)28-20-26-24-9-8-23-19-29(36)27(33-12-17-37-18-13-33)21-32(23,4)25(24)10-11-31(26,3)30(28)38-22(2)35;/h5,23-30,36H,1,6-21H2,2-4H3;1H/q+1;/p-1/t23-,24+,25-,26-,27-,28-,29-,30-,31-,32-;/m0./s1 ☒N
  • Key:OYTJKRAYGYRUJK-FMCCZJBLSA-M ☒N
  (verify)

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ ଏବଂ ଉଚ୍ଚ ରକ୍ତଚାପ ଅନ୍ତର୍ଭୁକ୍ତ | [୩] ଅନ୍ୟାନ୍ୟ ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ ଦୀର୍ଘସ୍ଥାୟୀ ମାଂସପେଶୀ ଦୁର୍ବଳତା ହୋଇପାରେ | [୫] [୮] ଗର୍ଭାବସ୍ଥାରେ ଭଲ ଅଧ୍ୟୟନ କରାଯାଇ ନଥିଲେ ମଧ୍ୟ କୌଣସି କ୍ଷତି ହୋଇ ନାହିଁ | [୯] ବ୍ୟବହାର ପରେ ଅଳ୍ପ ସମୟ ପରେ ସ୍ତନ୍ୟପାନ କରାଇହୁଏ | [୧୦] ରୋକୁରୋନିୟମ ଏକ ଅଣ-ଡିପୋଲାରାଇଜିଙ୍ଗ ଶ୍ରେଣୀର ନିଉରୋମସ୍କୁଲାର ବ୍ଲକର | [୧୧]

୧୯୯୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ରୋକୁରୋନିଅମ ଅନୁମୋଦିତ ହୋଇଥିଲା | [୩] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଅଟେ | [୧୨] [୧୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ 500 ମିଗ୍ରା ପାଇଁ ୨୦୨୦ ସୁଦ୍ଧା ୪୦ ଡଲାର ଥିଲା ।[୧୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶି ମୂଲ୍ୟ ପ୍ରାୟ ୨୫ ପାଉଣ୍ଡ | [୧୫] ରୋକୁରୋନିୟମ କୋଠରୀ ତାପମାତ୍ରାରେ ପ୍ରାୟ ୧୨ ସପ୍ତାହ ସନ୍ତୁଳିତ ରହେ | [୭]

ଆଧାର

ସମ୍ପାଦନା
  1. ↑ ୧.୦ ୧.୧ "Rapid sequence intubation - WikEM". wikem.org (in ଇଂରାଜୀ). Archived from the original on 3 August 2020. Retrieved 19 August 2020.
  2. ↑ "Succinylcholine vs. Rocuronium: Battle of the RSI Paralytics". JEMS. 14 May 2019. Archived from the original on 24 September 2020. Retrieved 28 September 2020.
  3. ↑ ୩.୦ ୩.୧ ୩.୨ "Rocuronium Bromide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 June 2019. Retrieved 19 August 2020.
  4. ↑ Tran, DT; Newton, EK; Mount, VA; Lee, JS; Wells, GA; Perry, JJ (29 October 2015). "Rocuronium versus succinylcholine for rapid sequence induction intubation". The Cochrane Database of Systematic Reviews. 10 (10): CD002788. doi:10.1002/14651858.CD002788.pub3. PMC 7104695. PMID 26512948.
  5. ↑ ୫.୦ ୫.୧ ୫.୨ "Rocuronium Bromide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 June 2019. Retrieved 19 August 2020.
  6. ↑ "Rapid sequence intubation - WikEM". wikem.org (in ଇଂରାଜୀ). Archived from the original on 3 August 2020. Retrieved 19 August 2020.
  7. ↑ ୭.୦ ୭.୧ "Succinylcholine vs. Rocuronium: Battle of the RSI Paralytics". JEMS. 14 May 2019. Archived from the original on 24 September 2020. Retrieved 28 September 2020.
  8. ↑ Jain, Ankit; Wermuth, Harrison R.; Maani, Christopher V. (2020). "Rocuronium". StatPearls. StatPearls Publishing. Archived from the original on 29 August 2021. Retrieved 19 August 2020.
  9. ↑ "Rocuronium (Zemuron) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 19 August 2020.
  10. ↑ "Rocuronium". Drugs and Lactation Database (LactMed). National Library of Medicine (US). 2006. Archived from the original on 30 November 2020. Retrieved 19 August 2020.
  11. ↑ "Rocuronium - WikEM". wikem.org. Archived from the original on 4 October 2017. Retrieved 19 August 2020.
  12. ↑ "Rocuronium (Zemuron) | Davis's Drug Guide". nursing.unboundmedicine.com (in ଇଂରାଜୀ). Archived from the original on 13 August 2020. Retrieved 19 August 2020.
  13. ↑ BNF 79. London: Pharmaceutical Press. March 2020. p. 1379. ISBN 978-0857113658.
  14. ↑ "Rocuronium Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 November 2019. Retrieved 19 August 2020.
  15. ↑ BNF 79. London: Pharmaceutical Press. March 2020. p. 1379. ISBN 978-0857113658.
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