ରିସଡିପ୍ଲାମ

ରିସଡିପ୍ଲାମ
Clinical data
Trade names	Evrysdi
Synonyms	RG7916; RO7034067
AHFS/Drugs.com	monograph
data	US DailyMed: Risdiplam;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name 7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one;
ECHA InfoCard	100.278.103
Chemical and physical data
Formula	C22H23N7O
Molar mass	୪୦୧.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=CC(=NN2C1=NC(=C2)C)C3=CC(=O)N4C=C(C=CC4=N3)N5CCNC6(C5)CC6;
	InChI InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3; Key:ASKZRYGFUPSJPN-UHFFFAOYSA-N;

ରିସଡିପ୍ଲାମ, ବିକ୍ରୟ ନାମ ଏଭ୍ରିସଡି, ହେଉଛି ମେରୁଦଣ୍ଡର ମାଂସପେଶୀ ଆଟ୍ରୋଫି (SMA) ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୧] ଏହାର ଟାଇପ୍ ୧, ଟାଇପ୍ ୨ ଏବଂ ଟାଇପ୍ ୩, ଏହି ତିନି ପ୍ରକାର ରୋଗ ଅଛି ।^[୩] ଯେଉଁମାନଙ୍କର ଅତିକମରେ ଦୁଇମାସ ରୋଗ ଅଛି, ସେମାନଙ୍କଠାରେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୧] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଜ୍ୱର, ତରଳ ଝାଡ଼ା, ରାସ, ନିମୋନିଆ ଏବଂ ବାନ୍ତି ହୋଇପାରେ ।^[୧] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୪] ଏହା ମୋଟର ନ୍ୟୁରନ୍ ୨-ନିର୍ଦ୍ଦେଶିତ ଆରଏନଏ ସ୍ପ୍ଲାଇସିଙ୍ଗ ମୋଡିଫାୟର୍ ।^[୧]

୨୦୨୦ ମସିହାରେ ଆମେରିକାରେ ଏବଂ ୨୦୨୧ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ରିସଡିପ୍ଲାମକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୫] ^[୩] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ୬୦ ମିଗ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୧୧,୭୦୦ ଡଲାର ଅଟେ ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶିର ମୂଲ୍ୟ ୭୯୦୦ ପାଉଣ୍ଡ ଅଟେ ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ Food and Drugs Administration (FDA) (18 August 2020). "Evrysdi- risdiplam powder, for solution". DailyMed. Bethesda, Maryland, United States: MedLine by the National Library of Medicine (NLM) of the United States National Institutes of Health (NIH). Archived from the original on 29 August 2021. Retrieved 24 September 2020.
↑ O'Keefe, Lindsey (7 August 2020). "FDA Approves Oral Treatment for Spinal Muscular Atrophy" (Press release). Silver Spring, Maryland, United States of America: United States Food and Drug Administration (FDA). FDA Newsroom Department. Archived from the original on 11 August 2020. Retrieved 7 August 2020. This article incorporates text from this source, which is in the public domain.
↑ ^୩.୦ ^୩.୧ "Evrysdi". Archived from the original on 6 October 2021. Retrieved 18 October 2021.
↑ "Risdiplam (Evrysdi) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 October 2020. Retrieved 18 October 2021.
↑ "Risdiplam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 October 2021. Retrieved 18 October 2021.
↑ "Evrysdi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 18 October 2021.
↑ "Risdiplam". SPS - Specialist Pharmacy Service. 6 February 2019. Archived from the original on 18 October 2021. Retrieved 18 October 2021.

[PI2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ ^୧.୫ Food and Drugs Administration (FDA) (18 August 2020). "Evrysdi- risdiplam powder, for solution". DailyMed. Bethesda, Maryland, United States: MedLine by the National Library of Medicine (NLM) of the United States National Institutes of Health (NIH). Archived from the original on 29 August 2021. Retrieved 24 September 2020.

[FDA_PR-2] O'Keefe, Lindsey (7 August 2020). "FDA Approves Oral Treatment for Spinal Muscular Atrophy" (Press release). Silver Spring, Maryland, United States of America: United States Food and Drug Administration (FDA). FDA Newsroom Department. Archived from the original on 11 August 2020. Retrieved 7 August 2020. This article incorporates text from this source, which is in the public domain.

[EPAR2021-3] ୩.୦ ^୩.୧ "Evrysdi". Archived from the original on 6 October 2021. Retrieved 18 October 2021.

[4] "Risdiplam (Evrysdi) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 30 October 2020. Retrieved 18 October 2021.

[AHFS2021-5] "Risdiplam Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 October 2021. Retrieved 18 October 2021.

[6] "Evrysdi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 18 October 2021.

[7] "Risdiplam". SPS - Specialist Pharmacy Service. 6 February 2019. Archived from the original on 18 October 2021. Retrieved 18 October 2021.

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