ମେଥୋକାର୍ବାମୋଲ

ମେଥୋକାର୍ବାମୋଲ
Clinical data
Trade names	Robaxin, Marbaxin, others
AHFS/Drugs.com	monograph
MedlinePlus	a682579
data	US DailyMed: Methocarbamol;
Pregnancy; category	AU: B2 ; ;
Routes of; administration	By mouth, intravenous
ATC code	M03BA03 (WHO) M03BA53 M03BA73;
Legal status
Legal status	CA: OTC ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	1.14–1.24 hours
Identifiers
	IUPAC name (RS)-2-hydroxy-3-(2-methoxyphenoxy)propyl carbamate;
CAS Number	532-03-6 ;
PubChem CID	4107;
IUPHAR/BPS	6829;
DrugBank	DB00423 ;
ChemSpider	3964 ;
UNII	125OD7737X;
KEGG	D00402 ;
ChEBI	CHEBI:6832 ;
ChEMBL	CHEMBL1201117 ;
ECHA InfoCard	100.007.751
Chemical and physical data
Formula	C11H15NO5
Molar mass	୨୪୧.୨୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(O)COc1ccccc1OC)N;
	InChI InChI=1S/C11H15NO5/c1-15-9-4-2-3-5-10(9)16-6-8(13)7-17-11(12)14/h2-5,8,13H,6-7H2,1H3,(H2,12,14) ; Key:GNXFOGHNGIVQEH-UHFFFAOYSA-N ;
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ମେଥୋକାର୍ବାମୋଲ (ଇଂରାଜୀ ଭାଷାରେ Methocarbamo), ଏକ ବ୍ୟବସାୟୀକ ନାମ Robaxin, ଏକ ଔଷଧ ଯାହା ସ୍ୱଳ୍ପକାଳୀନ ମାଂସପେଶୀ ଓ ହାଡ଼ ଯନ୍ତ୍ରଣା ନିମନ୍ତେ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ^[୪] ଏହା ବିଶ୍ରାମ, ଶାରୀରିକ ଚିକିତ୍ସା ଏବଂ ଅନ୍ୟାନ୍ୟ ଯନ୍ତ୍ରଣା ନିବାରକ ଔଷଧ ସହିତ ଏକତ୍ର ବ୍ୟବହାର କରାଯାଇପାରେ | ^[୩] ^[୫] ^[୬] କଟି ଯନ୍ତ୍ରଣାରେ ଏହା କମ୍ ପସନ୍ଦ କରାଯାଏ | ^[୩] ରିଉମାଟଏଡ ଆର୍ଥ୍ରାଇଟିସ ଏବଂ ସେରେବ୍ରାଲ୍ ପାଲ୍‌ସି ରୋଗମାନଙ୍କରେ ସୀମିତ ବ୍ୟ‌ବ‌ହାର କରାଯାଏ । ^[୩] ^[୭] ଔଷଧର ପ୍ରଭାବ ସାଧାରଣତଃ ଅଧ ଘଣ୍ଟା ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ | ^[୩] ଏହା ପାଟିରେ କିମ୍ବା ଶିରାଭ୍ୟନ୍ତର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ | ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା, ନିଦ୍ରାଳୁ, ମୁଣ୍ଡ ବୁଲାଇବା ଇତ୍ୟାଦି ହୁଏ । ^[୩] ^[୮] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲାକ୍‌ସିସ୍, ଯକୃତ ସମସ୍ୟା, ଦ୍ୱନ୍ଦ୍ୱ ଏବଂ ବାତ ମାରିପାରେ । ^[୯] ଗର୍ଭାବସ୍ଥା ଏବଂ ସ୍ତନ୍ୟପାନ କରାଇବା ସମୟରେ ଏହା ବ୍ୟବହାର କରିବାକୁ ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୩] ^[୯] ବୃଦ୍ଧଙ୍କ ବ୍ୟବହାର ଅଧିକ ବିପଦ ଜନ‌କ ବୋଲି ବିବେଚନା କରାଯାଏ। ^[୩] ମେଥୋକାର୍ବାମୋଲ ହେଉଛି ଏକ କେନ୍ଦ୍ରୀୟ କାର୍ଯ୍ୟ କରୁଥିବା ମାଂସପେଶୀ ଶିଥିଳକରୀ ଔଷଧ । ^[୩] ଏହା କିପରି କାମ କରେ ତାହା ଅସ୍ପଷ୍ଟ, କିନ୍ତୁ ଏହା ସିଧାସଳଖ ମାଂସପେଶୀକୁ ପ୍ରଭାବିତ କରୁଥିବା ପରି ଜଣାଯାଏ ନାହିଁ | ^[୩]

ମେଥୋକାର୍ବାମୋଲ ୧୯୫୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ନିମନ୍ତେ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୩] ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୩] ^[୯] ଏହା ୨୦୧୬ ମସିହାର ଅପେକ୍ଷାକୃତ ଶସ୍ତା ଥିଲା । ^[୧୦] ୨୦୧୭ ମସିହାର ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରର ୧୭୮ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ ଔଷଧ ଥିଲା, ଯାହାର ତିନି ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା। ^[୧୧] ^[୧୨]

ଆଧାର

↑ "Robaxin-750 - Summary of Product Characteristics (SmPC)". (emc). 8 August 2017. Retrieved 19 April 2020.
↑ Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G (1990). "Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals". European Journal of Clinical Pharmacology. 39 (2): 193–4. doi:10.1007/BF00280060. PMID 2253675. S2CID 626920.
↑ ^୩.୦୦ ^୩.୦୧ ^୩.୦୨ ^୩.୦୩ ^୩.୦୪ ^୩.୦୫ ^୩.୦୬ ^୩.୦୭ ^୩.୦୮ ^୩.୦୯ ^୩.୧୦ ^୩.୧୧ ^୩.୧୨ "Methocarbamol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists.
↑ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 9780857113382.
↑ "Robaxin- methocarbamol tablet, film coated". DailyMed. 18 July 2019. Retrieved 19 April 2020.
↑ "Robaxin- methocarbamol injection". DailyMed. 10 December 2018. Retrieved 19 April 2020.
↑ Richards, Bethan L.; Whittle, Samuel L.; Buchbinder, Rachelle (2012-01-18). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1: CD008922. doi:10.1002/14651858.CD008922.pub2. ISSN 1469-493X. PMID 22258993.
↑ "Methocarbamol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 30 January 2017. PMID 31643609.
↑ ^୯.୦ ^୯.୧ ^୯.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 9780857113382.
↑ Fine, Perry G. (2016). The Hospice Companion: Best Practices for Interdisciplinary Care of Advanced Illness. Oxford University Press. p. PT146. ISBN 978-0-19-045692-4.
↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
↑ "Methocarbamol - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

[1] "Robaxin-750 - Summary of Product Characteristics (SmPC)". (emc). 8 August 2017. Retrieved 19 April 2020.

[halflife-2] Sica DA, Comstock TJ, Davis J, Manning L, Powell R, Melikian A, Wright G (1990). "Pharmacokinetics and protein binding of methocarbamol in renal insufficiency and normals". European Journal of Clinical Pharmacology. 39 (2): 193–4. doi:10.1007/BF00280060. PMID 2253675. S2CID 626920.

[AHFS2019-3] ୩.୦୦ ^୩.୦୧ ^୩.୦୨ ^୩.୦୩ ^୩.୦୪ ^୩.୦୫ ^୩.୦୬ ^୩.୦୭ ^୩.୦୮ ^୩.୦୯ ^୩.୧୦ ^୩.୧୧ ^୩.୧୨ "Methocarbamol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists.

[BNF76-4] British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 9780857113382.

[Robaxin_tablet_FDA_label-5] "Robaxin- methocarbamol tablet, film coated". DailyMed. 18 July 2019. Retrieved 19 April 2020.

[Robaxin_injection_FDA_label-6] "Robaxin- methocarbamol injection". DailyMed. 10 December 2018. Retrieved 19 April 2020.

[Ric2012-7] Richards, Bethan L.; Whittle, Samuel L.; Buchbinder, Rachelle (2012-01-18). "Muscle relaxants for pain management in rheumatoid arthritis". The Cochrane Database of Systematic Reviews. 1: CD008922. doi:10.1002/14651858.CD008922.pub2. ISSN 1469-493X. PMID 22258993.

[Liver2017-8] "Methocarbamol". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 30 January 2017. PMID 31643609.

[autogen1-9] ୯.୦ ^୯.୧ ^୯.୨ British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1093. ISBN 9780857113382.

[Ox2016-10] Fine, Perry G. (2016). The Hospice Companion: Best Practices for Interdisciplinary Care of Advanced Illness. Oxford University Press. p. PT146. ISBN 978-0-19-045692-4.

[11] "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.

[12] "Methocarbamol - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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