ମାଇକାଫଙ୍ଗିନ

ମାଇକାଫଙ୍ଗିନ
Clinical data
Trade names	Mycamine
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Micafungin;
Pregnancy; category	C;
Routes of; administration	Intravenous
Legal status
Legal status	US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Protein binding	99.8%
Metabolism	Via catechol-O-methyltransferase pathway
Elimination half-life	11–17 hours
Excretion	40% feces, <15% urine
Identifiers
	IUPAC name {5-[(1S,2S)-2-[(3S,6S,9S,11R,15S,18S,20R,21R,24S,25S,26S)-3-[(1R)-2-carbamoyl-1-hydroxyethyl]-11,20,21,25-tetrahydroxy-15-[(1R)-1-hydroxyethyl]-26-methyl-2,5,8,14,17,23-hexaoxo-18-[(4-{5-[4-(pentyloxy)phenyl]-1,2-oxazol-3-yl}benzene)amido]-1,4,7,13,16,22-hexaazatricyclo[22.3.0.09,13]heptacosan-6-yl]-1,2-dihydroxyethyl]-2-hydroxyphenyl}oxidanesulfonic acid;
Chemical and physical data
Formula	C56H71N9O23S
Molar mass	୧,୨୭୦.୨୮ g·mol−1
	InChI InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39-21-33(63-87-39)27-7-9-29(10-8-27)49(75)58-34-20-38(70)52(78)62-54(80)45-46(72)25(2)23-65(45)56(82)43(37(69)22-41(57)71)60-53(79)44(48(74)47(73)30-13-16-36(68)40(18-30)88-89(83,84)85)61-51(77)35-19-31(67)24-64(35)55(81)42(26(3)66)59-50(34)76/h7-16,18,21,25-26,31,34-35,37-38,42-48,52,66-70,72-74,78H,4-6,17,19-20,22-24H2,1-3H3,(H2,57,71)(H,58,75)(H,59,76)(H,60,79)(H,61,77)(H,62,80)(H,83,84,85)/t25-,26-,31+,34-,35-,37+,38+,42-,43-,44-,45-,46-,47-,48-,52+/m0/s1 ; Key:PIEUQSKUWLMALL-NFGJWQNFSA-N ;
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ମାଇକାଫଙ୍ଗିନ, ମାଇକାମାଇନ ନାମରେ ମଧ୍ୟ ବିକ୍ରି ହେଉଛି, ଏକ ଆଣ୍ଟିଫଙ୍ଗାଲ୍ ଔଷଧ ଯାହା ଗୁରୁତର କାଣ୍ଡିଡିଆସିସ୍ ରୋଗର ଚିକିତ୍ସା କିମ୍ବା ପ୍ରତିଷେଧ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ।^[୧] ଏହା ଆସ୍ପର୍ଗିଲୋସିସ୍ ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୨] ଏହା ଏକ ଶିରାରେ ଧୀରେ ଧୀରେ ଇଞ୍ଜେକସ ଆକାରରେ ଦିଆଯାଏ । ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା, <a href="./ରକ୍ତହୀନତା" rel="mw:WikiLink" data-linkid="169" data-cx="{"adapted":true,"sourceTitle":{"title":"Anemia","thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Iron_deficiency_anemia_blood_film.jpg/80px-Iron_deficiency_anemia_blood_film.jpg","width":80,"height":60},"description":"Reduced ability of blood to carry oxygen","pageprops":{"wikibase_item":"Q5445"},"pagelanguage":"en"},"targetTitle":{"title":"ରକ୍ତହୀନତା","thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/f/f2/Iron_deficiency_anemia_blood_film.jpg/80px-Iron_deficiency_anemia_blood_film.jpg","width":80,"height":60},"pageprops":{"wikibase_item":"Q5445"},"pagelanguage":"or"},"targetFrom":"link"}" class="mw-redirect cx-link" id="mwFA" title="ରକ୍ତହୀନତା">ସ୍ୱଳ୍ପ</a> ଲାଲ ରକ୍ତ କଣିକା, କମ୍ ପୋଟାସିୟମ୍, କମ୍ କ୍ୟାଲସିୟମ୍, ଅଇ, ଯକୃତ ସମସ୍ୟା ଏବଂ ଜ୍ୱର ହୋଇପାରେ ।^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ ବୃକ୍‌କ ସମସ୍ୟା ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୩] ଏହା ଏକ ଇକିନୋଚାଣ୍ଡିନ ଯାହା ଫଙ୍ଗାଲ୍ କୋଷ ପ୍ରାଚୀରର ଏକ ଅତ୍ୟାବଶ୍ୟକ ଉପାଦାନ ବିଟା -3-ଗ୍ଲୁକାନ୍ ଉତ୍ପାଦନକୁ ବନ୍ଦ କରିଥାଏ | ^[୧]

୨୦୦୫ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ର ଏବଂ ୨୦୦୮ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ମାଇକାଫଙ୍ଗିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ^[୧] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୪] ଏହା ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଅଛି ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦୦ ମିଗ୍ରା ବିଶିଷ୍ଟ ୭ ମାତ୍ରାର ମୂଲ୍ୟ ପ୍ରାୟ ୩୭୦ ଡଲାର ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୨୦୦୦ ପାଉଣ୍ଡ ଅଟେ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Mycamine". Archived from the original on 10 March 2021. Retrieved 18 November 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Micafungin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 July 2021. Retrieved 18 November 2021.
↑ "Micafungin (Mycamine) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 18 November 2021.
↑ ^୪.୦ ^୪.୧ "Micafungin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 November 2021.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 632. ISBN 978-0857114105.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ "Mycamine". Archived from the original on 10 March 2021. Retrieved 18 November 2021.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ "Micafungin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 24 July 2021. Retrieved 18 November 2021.

[3] "Micafungin (Mycamine) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 18 November 2021.

[GX2021-4] ୪.୦ ^୪.୧ "Micafungin Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 18 November 2021.

[WHO22nd-5] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[BNF81-6] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 632. ISBN 978-0857114105.

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