ବେରୋଟ୍ରାଲଷ୍ଟାଟ

ବେରୋଟ୍ରାଲଷ୍ଟାଟ
Clinical data
Trade names	Orladeyo
Synonyms	BCX7353, BCX-7353
AHFS/Drugs.com	monograph
data	EU EMA: yes; US DailyMed: Berotralstat;
Routes of; administration	By mouth
Legal status
Legal status	CA: ℞-only ; US: ℞-only ; EU: Rx-only ;
Identifiers
	IUPAC name 2-[3-(aminomethyl)phenyl]-N-[5-[(R)-(3-cyanophenyl)-(cyclopropylmethylamino)methyl]-2-fluorophenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide;
Chemical and physical data
Formula	C30H26F4N6O
Molar mass	୫୬୨.୫୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES NCC1=CC(=CC=C1)N1N=C(C=C1C(=O)NC1=CC(=CC=C1F)[C@H](NCC1CC1)C1=CC=CC(=C1)C#N)C(F)(F)F;
	InChI InChI=1S/C30H26F4N6O/c31-24-10-9-22(28(37-17-18-7-8-18)21-5-1-3-19(11-21)15-35)13-25(24)38-29(41)26-14-27(30(32,33)34)39-40(26)23-6-2-4-20(12-23)16-36/h1-6,9-14,18,28,37H,7-8,16-17,36H2,(H,38,41)/t28-/m1/s1; Key:UXNXMBYCBRBRFD-MUUNZHRXSA-N;

ବେରୋଟ୍ରାଲଷ୍ଟାଟ, (ଇଂରାଜୀ ଭାଷାରେ Berotralstat) ଓର୍ଲାଡେୟୋ ଏହାର ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ବଂଶାନୁକ୍ରମିକ ଆଞ୍ଜିଓଇଡିମା (HAE) ରୋଗର ପ୍ରତିଷେଧ ଭାବରେ ବ୍ୟବ‌ହୃତ ହୁଏ ।^[୩] ବାର ବର୍ଷ ଓ ତଦୁର୍ଦ୍ଧ୍ୱ ବୟସରେ ଏହା ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ପେଟ ଯନ୍ତ୍ରଣା, ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ପିଠି ଯନ୍ତ୍ରଣା ଏବଂ ବୁକୁଜ୍ୱାଳା ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କ୍ୟୁଟି ବିସ୍ତାର ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ କ୍ଷତିର କୌଣସି ପ୍ରମାଣ ନଥିବାବେଳେ, ଏହାର ବ୍ୟବହାର ଭଲ ଭାବରେ ଅଧ୍ୟୟନ କରାଯାଇ ନାହିଁ ।^[୩] ଏହା ଏକ ପ୍ଲାଜ୍ମା କାଲିକ୍ରିନ୍ ପ୍ରତିରୋଧକ ।^[୩]

୨୦୨୦ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୨୧ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ବେରୋଟ୍ରାଲଷ୍ଟାଟ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୦ ସପ୍ତାହ ସୁଦ୍ଧା ଏହାର ମୂଲ୍ୟ ପ୍ରାୟ ୨୦,୨୦୦ ଅଟେ | ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୪୦,୫୦୦ ଡଲାର ଅଟେ ।^[୬]

ଆଧାର

↑ https://pdf.hres.ca/dpd_pm/00066149.PDF Archived 1 October 2022 at the Wayback Machine. ଛାଞ୍ଚ:Bare URL PDF
↑ ^୨.୦ ^୨.୧ "Orladeyo EPAR". European Medicines Agency (EMA). 24 February 2021. Archived from the original on 12 July 2021. Retrieved 12 July 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ ^୩.୮ "Orladeyo- berotralstat hydrochloride capsule". DailyMed. Archived from the original on 1 November 2022. Retrieved 25 December 2020.
↑ "Drug Trials Snapshot: Orladeyo". U.S. Food and Drug Administration. 3 December 2020. Archived from the original on 24 October 2021. Retrieved 25 December 2020. This article incorporates text from this source, which is in the public domain.
↑ "Berotralstat". SPS - Specialist Pharmacy Service. 21 July 2018. Archived from the original on 12 December 2021. Retrieved 3 November 2022.
↑ "Orladeyo Prices, Coupons, Copay & Patient Assistance". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 May 2022. Retrieved 3 November 2022.

[1] ttps://pdf.hres.ca/dpd_pm/00066149.PDF Archived 1 October 2022 at the Wayback Machine. ଛାଞ୍ଚ:Bare URL PDF

[EPAR2022-2] ୨.୦ ^୨.୧ "Orladeyo EPAR". European Medicines Agency (EMA). 24 February 2021. Archived from the original on 12 July 2021. Retrieved 12 July 2021.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ ^୩.୮ "Orladeyo- berotralstat hydrochloride capsule". DailyMed. Archived from the original on 1 November 2022. Retrieved 25 December 2020.

[FDA_snapshot-4] "Drug Trials Snapshot: Orladeyo". U.S. Food and Drug Administration. 3 December 2020. Archived from the original on 24 October 2021. Retrieved 25 December 2020. This article incorporates text from this source, which is in the public domain.

[5] "Berotralstat". SPS - Specialist Pharmacy Service. 21 July 2018. Archived from the original on 12 December 2021. Retrieved 3 November 2022.

[6] "Orladeyo Prices, Coupons, Copay & Patient Assistance". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 May 2022. Retrieved 3 November 2022.

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