ବୁସଲଫାନ

<span title="International nonproprietary name (INN): <nowiki>Mr. Ibrahem/Busulfan</nowiki>">Mr. Ibrahem/Busulfan
Clinical data
Trade names	Myleran, Busilvex, Busulfex IV, others
Other names	Busulphan, 1,4-butanediol dimethanesulfonate
AHFS/Drugs.com	Monograph
MedlinePlus	a682248
License data	<abbr class="country-name" title="<nowiki>European Union</nowiki>">EU EMA: by INN[permanent dead link]; <abbr class="country-name" title="<nowiki>United States</nowiki>">US DailyMed: Busulfan; <abbr class="country-name" title="<nowiki>United States</nowiki>">US FDA: Busulfan;
Pregnancy; ; category	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: D;
Routes of; ; administration	By mouth, intravenous
Drug class	Alkylating agent
Legal status
Legal status	<abbr class="country-name" title="<nowiki>Australia</nowiki>">AU: S4 (Prescription only) ; <abbr class="country-name" title="<nowiki>Canada</nowiki>">CA: ℞-only ; <abbr class="country-name" title="<nowiki>United Kingdom</nowiki>">UK: POM (Prescription only) ; <abbr class="country-name" title="<nowiki>United States</nowiki>">US: ℞-only ; <abbr class="country-name" title="<nowiki>European Union</nowiki>">EU: Rx-only ;
Pharmacokinetic data
Bioavailability	60–80% (oral)
Protein binding	32.4%
Metabolism	Liver
Elimination half-life	2.5 hours
Excretion	Urine (25–60%)
Identifiers
	IUPAC name Butane-1,4-diyl dimethanesulfonate;
Chemical and physical data
Formula	C6H14O6S2
Molar mass	246.29 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(OCCCCOS(=O)(=O)C)C;
	InChI InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3 ; Key:COVZYZSDYWQREU-UHFFFAOYSA-N ;
	(verify)

ବୁସଲଫାନ
Clinical data
Trade names	Myleran, Busilvex, Busulfex IV, others
Synonyms	Busulphan, 1,4-butanediol dimethanesulfonate
AHFS/Drugs.com	monograph
MedlinePlus	a682248
data	EU EMA: yes; US DailyMed: Busulfan;
Pregnancy; category	AU: D ; US: D (Evidence of risk) ; ;
Routes of; administration	By mouth, intravenous
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	60–80% (oral)
Protein binding	32.4%
Metabolism	Liver
Elimination half-life	2.5 hours
Excretion	Urine (25–60%)
Identifiers
	IUPAC name Butane-1,4-diyl dimethanesulfonate;
ECHA InfoCard	100.000.228
Chemical and physical data
Formula	C6H14O6S2
Molar mass	୨୪୬.୨୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=S(=O)(OCCCCOS(=O)(=O)C)C;
	InChI InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3 ; Key:COVZYZSDYWQREU-UHFFFAOYSA-N ;
(verify)

ବୁସଲଫାନ, ବେପାର ନାମ ମାଇଲେରାନ୍, ହେଉଛି ଏକ ଔଷଧ ଯାହା କ୍ରନିକ୍ ମାଇଲୋଜେନସ୍ ଲ୍ୟୁକେମିଆ (CML)ର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୧] ଏହା ଅସ୍ଥି ମଜ୍ଜା ପ୍ରତିରୋପଣ ପୂର୍ବରୁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାର |।^[୨] ଏହା ପାଟିରେ ଦିଆଯାଏ କିମ୍ବା ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ । ^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅସ୍ଥି ମଜ୍ଜା ଦମନ, ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ପାଟି ପ୍ରଦାହ, ରାସ ଦାଗ ଏବଂ ଫୁଲା ଅନ୍ତର୍ଭୁକ୍ତ । ^[୧] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ବାତ, ଅନୁର୍ବରତା, ଯକୃତ ସମସ୍ୟା, ଫୁସଫୁସ ସମସ୍ୟା ଏବଂ ଅଧିକ କର୍କଟ ହୋଇପାରେ । ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ । ^[୨] ଏହା ଏକ ଆଲକେଲେଟିଙ୍ଗ ପ୍ରତିନିଧି ଭାବରେ କାମକରେ । ^[୨]

୧୯୫୪ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ବୁସଲଫାନ ଅନୁମୋଦିତ ହୋଇଥିଲା। ^[୧] ଏହା ଏକ ସାଧାରଣ ଔଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୩] ୨ ମିଗ୍ରାର ୨୫ଟି ବଟିକାର ମୂଲ୍ୟ ଯୁକ୍ତରାଜ୍ୟରେ £ 70 ଥିବାବେଳେ 2021 ସୁଦ୍ଧା ୬୦ ମିଗ୍ରାର ୮ଭାଏଲର ମୂଲ୍ୟ ପ୍ରାୟ ୧,୫୫୦ ପାଉଣ୍ଡ ଅଟେ। ^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୮ ଭାଏଲର ମୂଲ୍ୟ ୪୨୦୦ ଡଲାର । ^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Busulfan Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 12 January 2022.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Busulfan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2021. Retrieved 12 January 2022.
↑ ^୩.୦ ^୩.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 937. ISBN 978-0857114105.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 937. ISBN 978-0857114105.
↑ "Busulfex Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 April 2021. Retrieved 12 January 2022.

[autogen1-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Busulfan Monograph for Professionals". Drugs.com. Archived from the original on 4 March 2021. Retrieved 12 January 2022.

[autogen2-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ "Busulfan Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2021. Retrieved 12 January 2022.

[BNF81-3] ୩.୦ ^୩.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 937. ISBN 978-0857114105.

[autogen4-4] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 937. ISBN 978-0857114105.

[5] "Busulfex Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 April 2021. Retrieved 12 January 2022.

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