ବାଲୋକ୍ସାଭିର ମାର୍ବୋକ୍ସିଲ

Baloxavir marboxil
Clinical data
Trade names	Xofluza
Synonyms	Baloxavir acid (BXA), BXM (S-033188), BXA (S-033447)
AHFS/Drugs.com	monograph
MedlinePlus	a618062
data	EU EMA: yes; US DailyMed: Baloxavir_marboxil;
Pregnancy; category	AU: B3 ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Identifiers
	IUPAC name ({(12aR)-12-[(11S)-7,8-Difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-6,8-dioxo-3,4,6,8,12,12a-hexahydro-1H-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin-7-yl}oxy)methyl methyl carbonate;
Chemical and physical data
Formula	C27H23F2N3O7S
Molar mass	୫୭୧.୫୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCOC(C(C=C1)=O)=C(N1N([C@@H]2C3=CC=CC=C3SCC4=C(F)C(F)=CC=C24)[C@@]5([H])N6CCOC5)C6=O)OC;
	InChI InChI=1S/C27H23F2N3O7S/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23/h2-9,21,23H,10-14H2,1H3/t21-,23+/m1/s1; Key:RZVPBGBYGMDSBG-GGAORHGYSA-N;

ବାଲୋକ୍ସାଭିର ମାର୍ବୋକ୍ସିଲ ( BXM ), ବେପାର ନାମ ଜୋ୍ଲୁଜା (Xofluza), ଏକ ଭୂତାଣୁରୋଧୀ ଔଷଧ ଯାହା ସ୍ୱାଇନ୍ ଫ୍ଲୁ (ଫ୍ଲୁ)ର ଚିକିତ୍ସା ତଥା ପ୍ରତିରୋଧ ପାଇଁ ବ୍ୟବହୃତ ହୁଏ । ^[୩] ଏହା ୧୧ ବର୍ଷରୁ ଅଧିକ ବୟସ୍କ ରୋଗୀମାନଙ୍କରେ ବ୍ୟବହୃତ ହୁଏ ଯେଉଁମାନେ ୪୮ ଘଣ୍ଟାରୁ କମ୍ ସମୟ ଧରି ଅସୁସ୍ଥ ଥିବେ । ^[୩] ଏହା ପୁନରୁଦ୍ଧାର ସମୟକୁ ପ୍ରାୟ ଗୋଟିଏ ଦିନ ହ୍ରାସ କରିଥାଏ । ^[୨] ଏହାକୁ ଗୋଟିଏ ମାତ୍ରା ଭାବରେ ଗ୍ରହଣ କରାଯାଏ ।^[୩]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ତରଳ ଝାଡ଼ା, ବ୍ରୋଙ୍କାଇଟିସ୍, ବାନ୍ତି, ସାଇନୁସାଇଟିସ୍ ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ । ^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଆନାଫାଇଲକ୍ସିସ୍ ହୋଇପାରେ । ^[୩] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ। ^[୩] ଏହା ଏକ ଇନ୍‌ଫ୍ଲୁଏଞ୍ଜା ଜୀବାଣୁ ପଲିମେରେଜ୍ ଏସିଡ୍ (PA) ଏଣ୍ଡୋନ୍ୟୁକ୍ଲିଜ୍ ଇନହିବିଟର । ^[୩]

ଆମେରିକା ଏବଂ ଜାପାନରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ବାଲୋକ୍ସାଭିର ମାର୍ବକ୍ସିଲକୁ ୨୦୧୮ ମସିହାରେ ଅନୁମୋଦନ କରାଯାଇଥିଲା। ^[୩] ^[୪] ୨୦୨୧ ମସିହାରେ ୟୁରୋପ ଏବଂ ବ୍ରିଟେନରେ ଏହାକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା। ^[୫] ୨୦୨୨ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହାର ଚିକିତ୍ସା ଖର୍ଚ୍ଚ ୧୬୦ ଡଲାର । ^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Xofluza Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 2 March 2020. Archived from the original on 13 March 2020. Retrieved 16 August 2020.
↑ ^୨.୦ ^୨.୧ "Xofluza EPAR". European Medicines Agency (EMA). 9 November 2020. Archived from the original on 30 January 2021. Retrieved 25 January 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ ^୩.୮ "Xofluza- baloxavir marboxil tablet, film coated". DailyMed. 28 October 2019. Archived from the original on 28 October 2020. Retrieved 9 January 2020.
↑ Heo, Young-A (April 2018). "Baloxavir: First Global Approval". Drugs. 78 (6): 693–697. doi:10.1007/s40265-018-0899-1.
↑ "Baloxavir marboxil". SPS - Specialist Pharmacy Service. 29 June 2018. Archived from the original on 26 July 2020. Retrieved 8 January 2022.
↑ "Baloxavir Marboxil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.

[Xofluza_APMDS-1] ୧.୦ ^୧.୧ "Xofluza Australian prescription medicine decision summary". Therapeutic Goods Administration (TGA). 2 March 2020. Archived from the original on 13 March 2020. Retrieved 16 August 2020.

[EPAR2022-2] ୨.୦ ^୨.୧ "Xofluza EPAR". European Medicines Agency (EMA). 9 November 2020. Archived from the original on 30 January 2021. Retrieved 25 January 2021.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ ^୩.୬ ^୩.୭ ^୩.୮ "Xofluza- baloxavir marboxil tablet, film coated". DailyMed. 28 October 2019. Archived from the original on 28 October 2020. Retrieved 9 January 2020.

[4] Heo, Young-A (April 2018). "Baloxavir: First Global Approval". Drugs. 78 (6): 693–697. doi:10.1007/s40265-018-0899-1.

[SP2022-5] "Baloxavir marboxil". SPS - Specialist Pharmacy Service. 29 June 2018. Archived from the original on 26 July 2020. Retrieved 8 January 2022.

[6] "Baloxavir Marboxil Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 8 January 2022.

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