ଫ୍ଲୁଭାଷ୍ଟାଟିନ

ଫ୍ଲୁଭାଷ୍ଟାଟିନ
Clinical data
Trade names	Lescol, others
AHFS/Drugs.com	monograph
MedlinePlus	a694010
Pregnancy; category	AU: D ; US: X (Contraindicated) ; ;
Routes of; administration	By mouth (capsules, tablets)
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ; ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	24–30%
Protein binding	>98%
Metabolism	Liver: CYP2C9 (75%), CYP3A4 (20%), CYP2C8 (5%)
Elimination half-life	1–3 hours (capsule), 9 hours (XR formulations)
Excretion	Faeces (95%), urine (5%)
Identifiers
	IUPAC name (3R,5S,6E)-7-[3-(4-Fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid;
ECHA InfoCard	100.224.327
Chemical and physical data
Formula	C24H26FNO4
Molar mass	୪୧୧.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)C[C@H](O)C[C@H](O)/C=C/c2c(c1ccccc1n2C(C)C)c3ccc(F)cc3;
	InChI InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m1/s1 ; Key:FJLGEFLZQAZZCD-MCBHFWOFSA-N ;
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ଫ୍ଲୁଭାଷ୍ଟାଟିନ (ଇଂରାଜୀ ଭାଷାରେ Fluvastatin), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଲେସ୍କୋଲ ଏକ ବିକ୍ରୟ ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତକୋଲେଷ୍ଟେରଲ ଏବଂ ଉଚ୍ଚ ଟ୍ରାଇଗ୍ଲିସେରାଇଡ ଅବସ୍ଥାମାନଙ୍କର ଚିକିତ୍ସା ଏବଂ ହୃଦରୋଗକୁ ପ୍ରତିରୋଧ କରିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ^[୫] ଏହା ଉପ‌ଯୁକ୍ତ ଖାଦ୍ୟ ଏବଂ ବ୍ୟାୟାମ ସହିତ ଏକତ୍ର ବ୍ୟବହୃତ ହୁଏ ।^[୫] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୪] ଔଷଧର ସର୍ବାଧିକ ପ୍ରଭାବ ପାଇଁ ୪ ସପ୍ତାହ ପର୍ଯ୍ୟନ୍ତ ଆବଶ୍ୟକ ହୋଇପାରେ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମାଂସପେଶୀ ଯନ୍ତ୍ରଣା, ବୁକୁଜ୍ୱାଳା, ବାନ୍ତି, ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ହୋଇପାରେ ।^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମାଂସପେଶୀହାନୀ, ଯକୃତ ସମସ୍ୟା, ଉଚ୍ଚ ରକ୍ତ ଶର୍କରା ଏବଂ ସ୍ମୃତି ସମସ୍ୟା ହୋଇପାରେ ।^[୫] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୫] ଏହା ଏକ ଷ୍ଟାଟିନ୍ ଯାହା ଏଚଏମଜି-ସିଓଏ ରିଡକ୍ଟେଜକୁ (HMG-CoA) ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୫]

ଫ୍ଲୁଭାଷ୍ଟାଟିନ ୧୯୮୨ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲା ଏବଂ ୧୯୯୩ରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୬] ^[୫] ସିମ୍‌ଭାଷ୍ଟାଟିନ୍‌ର ବିକଳ୍ପ ଭାବରେ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଲିପିବଦ୍ଧ ଅଛି ।^[୭] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ ସପ୍ତାହରେ ଏହି ଔଷଧ ପିଛା ୩ରୁ ୨୦ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୪]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Neuvonen PJ, Backman JT, Niemi M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955. S2CID 11716425.
↑ ^୨.୦ ^୨.୧ "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 18 March 2014. Retrieved 18 March 2014.
↑ Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.{{cite book}}: CS1 maint: unrecognized language (link)
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 218. ISBN 978-0857114105.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ ^୫.୭ "Fluvastatin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 13 December 2021.
↑ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 472. ISBN 9783527607495. Archived from the original on 2020-08-19. Retrieved 2021-10-05.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[PK-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ ^୧.୪ Neuvonen PJ, Backman JT, Niemi M (2008). "Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin". Clinical Pharmacokinetics. 47 (7): 463–74. doi:10.2165/00003088-200847070-00003. PMID 18563955. S2CID 11716425.

[MSR-2] ୨.୦ ^୨.୧ "Lescol, Lescol XR (fluvastatin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Archived from the original on 18 March 2014. Retrieved 18 March 2014.

[AC-3] Haberfeld H, ed. (2015). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.{{cite book}}: CS1 maint: unrecognized language (link)

[BNF81-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 218. ISBN 978-0857114105.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ ^୫.୭ "Fluvastatin Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 23 January 2021. Retrieved 13 December 2021.

[Fis2006-6] Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 472. ISBN 9783527607495. Archived from the original on 2020-08-19. Retrieved 2021-10-05.

[WHO22nd-7] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

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