ପ୍ଲାଜୋମାଇସିନ

Plazomicin
Clinical data
Pronunciation	pla" zoe mye' sin
Trade names	Zemdri
Synonyms	ACHN-490,; 6'-(Hydroxylethyl)-1-(HABA)-sisomicin
AHFS/Drugs.com	monograph
MedlinePlus	a618037
data	US DailyMed: Plazomicin;
Pregnancy; category	US: N (Not classified yet) ; ;
Routes of; administration	Intravenous infusion
Drug class	Aminoglycoside
ATC code	J01GB14 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name (2S)-4-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[[(2S,3R)-3-amino-6-[(2-hydroxyethylamino)methyl]-3,4-dihydro-2H-pyran-2-yl]oxy]-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide;
CAS Number	1154757-24-0;
PubChem CID	42613186;
DrugBank	DB12615;
ChemSpider	26390008;
UNII	LYO9XZ250J;
KEGG	D10151; as salt: D10655;
ChEMBL	CHEMBL1650559;
PDB ligand	EDS (PDBe, RCSB PDB);
Chemical and physical data
Formula	C25H48N6O10
Molar mass	୫୯୨.୬୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN[C@@H]1[C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3OC(=CC[C@H]3N)CNCCO)[C@@H](N)C[C@H]2NC(=O)[C@@H](O)CCN)OC[C@]1(C)O;
	InChI InChI=1S/C25H48N6O10/c1-25(37)11-38-24(18(35)21(25)29-2)41-20-15(31-22(36)16(33)5-6-26)9-14(28)19(17(20)34)40-23-13(27)4-3-12(39-23)10-30-7-8-32/h3,13-21,23-24,29-30,32-35,37H,4-11,26-28H2,1-2H3,(H,31,36)/t13-,14+,15-,16+,17+,18-,19-,20+,21-,23-,24-,25+/m1/s1; Key:IYDYFVUFSPQPPV-PEXOCOHZSA-N;

ପ୍ଲାଜୋମାଇସିନ, ଏକ ବ୍ୟବସାୟୀକ ନାମ ଜେମଡ୍ରି, ଏକ ଆମିନୋଗ୍ଲାଇକୋସାଇଡ ଆଣ୍ଟିବାୟିଟିକ ଯାହା ଜଟିଳ ମୂତ୍ରନଳୀ ସଂକ୍ରମଣର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ | ^[୧] ୨୦୧୯ ସୁଦ୍ଧା ଏହା କେବଳ ସେହିମାନଙ୍କ ପାଇଁ ସୁପାରିଶ କରାଯାଇଛି ଯେଉଁମାନଙ୍କ ପାଇଁ କିଛି ବିକଳ୍ପ ନାହିଁ | ^[୨] ଏହା ଶିରାବ୍ୟନ୍ତର ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ କିଡନୀ ସମସ୍ୟା, ତରଳ ଝାଡ଼ା, ବାନ୍ତି, ଏବଂ ରକ୍ତଚାପ ପରିବର୍ତ୍ତନ ଅନ୍ତର୍ଭୁକ୍ତ | ^[୧] ଅନ୍ୟାନ୍ୟ ଗୁରୁତର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶ୍ରବଣ ଶକ୍ତି ହ୍ରାସ, କ୍ଲୋଷ୍ଟ୍ରିଡିଅମ୍ ଡିଫିସିଲ ସମ୍ପର୍କୀୟ ତରଳ ଝାଡ଼ା, ଆନାଫାଇଲକ୍‌ସିସ ଏବଂ ମାଂସପେଶୀ ଦୁର୍ବଳତା ଅନ୍ତର୍ଭୁକ୍ତ | ^[୨] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଶିଶୁର କ୍ଷତି କରିପାରେ | ^[୨] ପ୍ରୋଟିନ୍ ତିଆରି କରିବାରେ ବ୍ୟାକ୍ଟେରିଆର କ୍ଷମତା ହ୍ରାସ କରି ପ୍ଲାଜୋମାଇସିନ କାର୍ଯକ୍ଷମ ହୁଏ । ^[୨]

୨୦୧୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ପାଇଁ ପ୍ଲାଜୋମାଇସିନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା | ^[୩] ^[୪] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଅଛି ।^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୦ ଦିନର ଚିକିତ୍ସାର ମୂଲ୍ୟ ପ୍ରାୟ ୬,୬୦୦ ଆମେରିକୀୟ ଡଲାର | ^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Plazomicin Sulfate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 10 October 2019.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Plazomicin Sulfate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 10 October 2019.
↑ "FDA Approved Drug Products: Zemdri". U.S. Food and Drug Administration. Retrieved 2018-06-28.
↑ "Drug Approval Package: Zemdri (plazomicin)". U.S. Food and Drug Administration. 5 July 2018. Retrieved 25 December 2019.
↑ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. hdl:10665/325771.
↑ "Zemdri Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 October 2019.

[AHFS2019-1] ୧.୦ ^୧.୧ "Plazomicin Sulfate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 10 October 2019.

[autogen1-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Plazomicin Sulfate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 10 October 2019.

[FDA_Zemdri_210303-3] "FDA Approved Drug Products: Zemdri". U.S. Food and Drug Administration. Retrieved 2018-06-28.

[4] "Drug Approval Package: Zemdri (plazomicin)". U.S. Food and Drug Administration. 5 July 2018. Retrieved 25 December 2019.

[WHO21st-5] World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. hdl:10665/325771.

[6] "Zemdri Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 10 October 2019.

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