ନେବିଭୋଲୋଲ

ନେବିଭୋଲୋଲ
Clinical data
Trade names	Nebilet, Bystolic, others
AHFS/Drugs.com	monograph
MedlinePlus	a608029
data	US DailyMed: Nebivolol;
Pregnancy; category	US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Protein binding	98%
Metabolism	Liver (CYP2D6-mediated)
Elimination half-life	12 hours
Excretion	Kidney and fecal
Identifiers
	IUPAC name (1RS,1' RS)-1,1'-[(2RS,2' SR)-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol ; OR; 1-(6-Fluorochroman-2-yl)-{[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino}ethanol; OR; 2,2'-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol); OR; 1-(6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-{[2-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2-hydroxyethyl]amino}ethan-1-ol;
Chemical and physical data
Formula	C22H25F2NO4
Molar mass	୪୦୫.୪୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc4cc1c(OC(CC1)C(O)CNCC(O)C3Oc2ccc(F)cc2CC3)cc4;
	InChI InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2 ; Key:KOHIRBRYDXPAMZ-UHFFFAOYSA-N ;
(verify)

ନେବିଭୋଲୋଲ ଏକ ବିଟା ବ୍ଲକର ଶ୍ରେଣୀର ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତଚାପ ଏବଂ ହୃଦ୍‌ପାତର ଚିକିତ୍ସା ପାଇଁ ଦିଆଯାଏ | ^[୨] ଉଚ୍ଚ ରକ୍ତଚାପ ପାଇଁ ଅନ୍ୟାନ୍ୟ β- ବ୍ଲକର୍ ପରି ଏହା ସାଧାରଣତଃ କମ୍ ପସନ୍ଦଯୋଗ୍ୟ ଚିକିତ୍ସା | ^[୩] ଏହା ଏକ‌କ ଭାବରେ କିମ୍ବା ଅନ୍ୟାନ୍ୟ ରକ୍ତଚାପର ଔଷଧ ସହିତ ବ୍ୟବହୃତ ହୋଇପାରେ | ^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ | ^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡ ବୁଲାଇବା, ଥକ୍କା ଅନୁଭବ, ବାନ୍ତି, ଏବଂ ମୁଣ୍ଡବିନ୍ଧା ଅନ୍ତର୍ଭୁକ୍ତ | ^[୩] ଗମ୍ଭୀର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦଘାତ ଏବଂ ବ୍ରୋଙ୍କୋସ୍ପାଜ୍ମ ହୋଇପାରେ | ^[୪] ଗର୍ଭାବସ୍ଥାରେ ଏବଂ ସ୍ତନ୍ୟପାନରେ ଏହାର ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ | ^[୨] ^[୫] ଏହା ହୃତ୍‌ପିଣ୍ଡ ଓ ସ୍ଫିତ ରକ୍ତନଳୀ ମଧ୍ୟରେ ଥିବା β1- ଆଡ୍ରେନର୍ଜିକ ରିସେପ୍ଟର ଗୁଡ଼ିକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ | ^[୪] ^[୬]

ନେବିଭୋଲୋଲ ୧୯୮୩ ମସିହାରେ ପେଟେଣ୍ଟ ହୋଇଥିଲେ ଏବଂ ୧୯୯୭ ମସିହାରେ ଡାକ୍ତରୀ ବ୍ୟବହାରରେ ଆସିଥିଲେ ^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ଏହା ଏକ ଜେନେରିକ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ | ^[୨] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ମାସ ଯୋଗାଣ ୨୦୨୦ ସୁଦ୍ଧା ପ୍ରାୟ ୩ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିଥାଏ । ^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣର ହୋଲସେଲ ମୂଲ୍ୟ ପ୍ରାୟ ୧୭୪ ଆମେରିକୀୟ ଡଲାର ଅଟେ। ^[୯] ୨୦୧୭ରେ, ଏହା ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୧୪୪ତମ ସାଧାରଣ ପ୍ରେସକ୍ରିପସନ୍ ଔଷଧ ଥିଲା, ଯେଉଁଥିରେ ଚାରି ଲକ୍ଷରୁ ଅଧିକ ପ୍ରେସକ୍ରିପସନ୍ ରହିଥିଲା | ^[୧୦] ^[୧୧]

ଆଧାର

↑ Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 183. ISBN 978-1-260-45231-0. Archived from the original on 10 October 2021. Retrieved 5 December 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 167. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ ^୩.୦ ^୩.୧ "Nebivolol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 19 October 2012. Retrieved 3 March 2019.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Nebivolol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 19 October 2012. Retrieved 3 March 2019.
↑ "Nebivolol Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 30 October 2020. Retrieved 3 March 2019.
↑ de Boer RA, Voors AA, van Veldhuisen DJ (July 2007). "Nebivolol: third-generation beta-blockade". Expert Opin Pharmacother. 8 (10): 1539–50. doi:10.1517/14656566.8.10.1539. PMID 17661735.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 462. ISBN 9783527607495. Archived from the original on 1 March 2019. Retrieved 1 March 2019.
↑ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 167. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Bystolic Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 15 February 2021. Retrieved 15 February 2021.
↑ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
↑ "Nebivolol Hydrochloride - Drug Usage Statistics (2008-2018)". clincalc.com. Archived from the original on 17 February 2021. Retrieved 17 February 2021. {{cite web}}: |archive-date= / |archive-url= timestamp mismatch; 13 ଜାନୁଆରୀ 2021 suggested (help)

[Katzung2021-1] Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (in ଇଂରାଜୀ) (15th ed.). New York: McGraw-Hill. p. 183. ISBN 978-1-260-45231-0. Archived from the original on 10 October 2021. Retrieved 5 December 2021.

[BNF80-2] ୨.୦ ^୨.୧ ^୨.୨ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 167. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[AHFS2019-3] ୩.୦ ^୩.୧ "Nebivolol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 19 October 2012. Retrieved 3 March 2019.

[autogen4-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ "Nebivolol Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 19 October 2012. Retrieved 3 March 2019.

[Preg2019-5] "Nebivolol Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 30 October 2020. Retrieved 3 March 2019.

[De2007-6] Boer RA, Voors AA, van Veldhuisen DJ (July 2007). "Nebivolol: third-generation beta-blockade". Expert Opin Pharmacother. 8 (10): 1539–50. doi:10.1517/14656566.8.10.1539. PMID 17661735.

[7] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 462. ISBN 9783527607495. Archived from the original on 1 March 2019. Retrieved 1 March 2019.

[autogen1-8] BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 167. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[BystolicPrice-9] "Bystolic Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 15 February 2021. Retrieved 15 February 2021.

[ref-10] "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.

[Clin2018-11] "Nebivolol Hydrochloride - Drug Usage Statistics (2008-2018)". clincalc.com. Archived from the original on 17 February 2021. Retrieved 17 February 2021. {{cite web}}: |archive-date= / |archive-url= timestamp mismatch; 13 ଜାନୁଆରୀ 2021 suggested (help)

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