ନେଟାରସୁଡିଲ

ନେଟାରସୁଡିଲ
Clinical data
Pronunciation	ne TAR soo dil
Trade names	Rhopressa, Rhokiinsa
Synonyms	AR-11324
AHFS/Drugs.com	monograph
MedlinePlus	a618014
data	EU EMA: yes; US DailyMed: Netarsudil;
Routes of; administration	Eye drops, topical
Legal status
Legal status	US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Metabolism	Esterases in the cornea
Metabolites	AR-13503 (active metabolite)
Elimination half-life	16–17 hrs
Duration of action	≥ 24 hrs
Identifiers
	IUPAC name [4-[(2S)-3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl]phenyl]methyl 2,4-dimethylbenzoate;
ECHA InfoCard	100.251.524
Chemical and physical data
Formula	C28H27N3O3
Molar mass	୪୫୩.୫୪ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc1ccc(c(c1)C)C(=O)OCc2ccc(cc2)[C@@H](CN)C(=O)Nc3ccc4cnccc4c3;
	InChI InChI=1S/C28H27N3O3/c1-18-3-10-25(19(2)13-18)28(33)34-17-20-4-6-21(7-5-20)26(15-29)27(32)31-24-9-8-23-16-30-12-11-22(23)14-24/h3-14,16,26H,15,17,29H2,1-2H3,(H,31,32)/t26-/m1/s1; Key:OURRXQUGYQRVML-AREMUKBSSA-N;

ନେଟାରସୁଡିଲ (ଇଂରାଜୀ ଭାଷାରେ Netarsudil), ରୋପ୍ରେସା ଏବଂ ରୋକିନ୍ସା ଏହାର ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଓପନ୍ ଆଙ୍ଗଲ୍ ଗ୍ଲକୋମା ସମେତ ବର୍ଦ୍ଧିତ ଇଣ୍ଟ୍ରାଓକୁଲାର ଚାପର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ^[୩] ଏହା ଆଖି ବୁନ୍ଦା ଭାବରେ ବ୍ୟବହୃତ ହୁଏ । ^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନାଲି ଆଖି, କଞ୍ଜୁକ୍ଟିଭାଲ୍ ରକ୍ତସ୍ରାବ, ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି ଏବଂ ଲୁହ ବୋହିବା ହୋଇପାରେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଜୀବାଣୁ ଜନିତ କେରାଟାଇଟିସ ହୋଇପାରେ ।^[୩] ଏହା ଏକ ଆରଏଚଓ କାଇନେଜ ଇନହିବିଟର (<a href="https://en.wikipedia.org/wiki/Rho_kinase_inhibitor" rel="mw:ExtLink" title="Rho kinase inhibitor" class="cx-link" data-linkid="191">rho kinase inhibitor</a>) | ^[୩]

୨୦୧୭ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୧୯ରେ ୟୁରୋପରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ନେଟରସୁଡିଲ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୩] ^[୧] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ଏହାର ୨.୫ ମିଲି ବୋତଲର ମୂଲ୍ୟ ପ୍ରାୟ ୩୦୫ଡଲାର ଅଟେ ।^[୪] ଏହା ନେଟାରସୁଡିଲ/ଲାଟାନୋପ୍ରୋଷ୍ଟ୍ ଔଷଧର ମିଶ୍ରଣ ଭାବରେ ମଧ୍ୟ ଉପଲବ୍ଧ | ^[୩] ୨୦୨୧ ସୁଦ୍ଧା ୟୁରୋପ ଏବଂ ବ୍ରିଟେନରେ ଏହା ବ୍ୟବସାୟିକ ଭାବରେ ଉପଲବ୍ଧ ନୁହେଁ ^[୫]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Rhokiinsa EPAR". European Medicines Agency (EMA). 16 September 2019. Archived from the original on 29 December 2019. Retrieved 27 September 2020.
↑ "Rhopressa- netarsudil solution/ drops". DailyMed. Archived from the original on 25 March 2021. Retrieved 2 May 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Netarsudil Mesylate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 June 2020. Retrieved 12 November 2021.
↑ "Rhopressa Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 12 November 2021.
↑ "Netarsudil". SPS - Specialist Pharmacy Service. 25 January 2016. Archived from the original on 13 November 2021. Retrieved 12 November 2021.

[EPAR2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Rhokiinsa EPAR". European Medicines Agency (EMA). 16 September 2019. Archived from the original on 29 December 2019. Retrieved 27 September 2020.

[Rhopressa_FDA_label-2] "Rhopressa- netarsudil solution/ drops". DailyMed. Archived from the original on 25 March 2021. Retrieved 2 May 2021.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ ^୩.୪ ^୩.୫ "Netarsudil Mesylate Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 June 2020. Retrieved 12 November 2021.

[4] "Rhopressa Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Retrieved 12 November 2021.

[5] "Netarsudil". SPS - Specialist Pharmacy Service. 25 January 2016. Archived from the original on 13 November 2021. Retrieved 12 November 2021.

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