ଡେକ୍ସରାଜୋକ୍ସେନ

ଡେକ୍ସରାଜୋକ୍ସେନ
Clinical data
Trade names	Zinecard, Cardioxane, others
Synonyms	Dexrazoxane hydrochloride
AHFS/Drugs.com	monograph
MedlinePlus	a609010
data	EU EMA: yes; US DailyMed: Dexrazoxane;
Pregnancy; category	US: N (Not classified yet) ; ;
Routes of; administration	Intravenous
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name 4-[(2S)-2-(3,5-Dioxopiperazin-1-yl)propyl]piperazine-2,6-dione;
ECHA InfoCard	100.163.459
Chemical and physical data
Formula	C11H16N4O4
Molar mass	୨୬୮.୨୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2NC(=O)CN(C[C@@H](N1CC(=O)NC(=O)C1)C)C2;
	InChI InChI=1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)/t7-/m0/s1 ; Key:BMKDZUISNHGIBY-ZETCQYMHSA-N ;
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ଡେକ୍ସରାଜୋକ୍ସେନ (ଇଂରାଜୀ ଭାଷାରେ Dexrazoxane), ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଜିନେକାର୍ଡ ଏକ ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଡକ୍ସୋରୁବିସିନ କାରଣରୁ ଏବଂ ଆନ୍ଥ୍ରାସାଇକ୍ଲିନ ବହିଷ୍କାର ଯୋଗୁ ହେଉଥିବା କାର୍ଡିଓମାଇଓପାଥିକୁ ରୋକିବା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୧] ^[୨] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୧]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା ରେ ଇଞ୍ଜେକସନ ନେଇଥିବା ସ୍ଥାନରେ ଯନ୍ତ୍ରଣା, ଅଇ, ଏବଂ ତରଳ ଝାଡ଼ା ହୋଇପାରେ ।^[୩] ^[୧] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅସ୍ଥି ମଜ୍ଜା ଦମନ ହୋଇପାରେ ।^[୩] ପିଲାମାନଙ୍କଠାରେ ଅଧିକ କର୍କଟ ରୋଗ ହେବାର ଆଶଙ୍କା ରହିପାରେ । ^[୪] ଏହା ଆନ୍ଥ୍ରାସାଇକ୍ଲିନ୍ ପାଇଁ ଏକ ଆଣ୍ଟିଡୋଟ ବା ପ୍ରତିବିଧାନ ଅଟେ ।^[୨]

୧୯୭୨ ମସିହାରେ ଡେକ୍ସରାଜୋକ୍ସେନ ଆବିଷ୍କୃତ ହୋଇଥିଲା ।^[୪] ୧୯୯୫ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏବଂ ୨୦୦୬ରେ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଏହାକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୧] ^[୨] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ୫୦୦ ମିଗ୍ରା ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୪୨୦ ଡଲାର ଥିଲା ।^[୫] ଯୁକ୍ତରାଜ୍ୟରେ ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୬୦ ପାଉଣ୍ଡ ଅଟେ ।^[୬]

ଆଧାର

↑ ^୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Dexrazoxane Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 23 December 2021.
↑ ^୨.୦ ^୨.୧ ^୨.୨ "Savene". Archived from the original on 12 November 2020. Retrieved 23 December 2021.
↑ ^୩.୦ ^୩.୧ "DailyMed - DEXRAZOXANE- dexrazoxane for injection injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 26 March 2021. Retrieved 23 December 2021.
↑ ^୪.୦ ^୪.୧ Kim, Kyu-Won; Roh, Jae Kyung; Wee, Hee-Jun; Kim, Chan (14 November 2016). Cancer Drug Discovery: Science and History (in ଇଂରାଜୀ). Springer. p. 250. ISBN 978-94-024-0844-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.
↑ "Dexrazoxane Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 April 2021. Retrieved 23 December 2021.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 984. ISBN 978-0857114105.

[AHFS2021-1] ୧.୦ ^୧.୧ ^୧.୨ ^୧.୩ "Dexrazoxane Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 23 December 2021.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ "Savene". Archived from the original on 12 November 2020. Retrieved 23 December 2021.

[PI2021-3] ୩.୦ ^୩.୧ "DailyMed - DEXRAZOXANE- dexrazoxane for injection injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 26 March 2021. Retrieved 23 December 2021.

[Kim2016-4] ୪.୦ ^୪.୧ Kim, Kyu-Won; Roh, Jae Kyung; Wee, Hee-Jun; Kim, Chan (14 November 2016). Cancer Drug Discovery: Science and History (in ଇଂରାଜୀ). Springer. p. 250. ISBN 978-94-024-0844-7. Archived from the original on 11 January 2022. Retrieved 23 December 2021.

[5] "Dexrazoxane Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 22 April 2021. Retrieved 23 December 2021.

[BNF81-6] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 984. ISBN 978-0857114105.

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