ଟ୍ରୋସପିୟମ

ଟ୍ରୋସପିୟମ
Clinical data
Trade names	Regurin, Sanctura, others
AHFS/Drugs.com	monograph
Pregnancy; category	C;
Routes of; administration	By mouth (tablets, capsules)
Legal status
Legal status	℞ (Prescription only);
Pharmacokinetic data
Protein binding	50–85%
Onset of action	Within 7 days
Elimination half-life	20 hours
Identifiers
	IUPAC name 3‑(2‑Hydroxy-2,2‑diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'‑pyrrolidin]-1'‑ium chloride;
ECHA InfoCard	100.030.784
Chemical and physical data
Formula	C25H30ClNO3
Molar mass	୪୨୭.୯୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC(c1ccccc1)(c2ccccc2)C(=O)O[C@@H]3C[C@@H]5CC[C@H](C3)[N+]45CCCC4;
	InChI InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+ ; Key:OYYDSUSKLWTMMQ-JKHIJQBDSA-N ;
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ଟ୍ରୋସପିୟମ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ସାନ୍କୁରା, ହେଉଛି ଏକ ଔଷଧ ଯାହାକି ଅତିସକ୍ରିୟ ମୂତ୍ରାଶୟ ଲକ୍ଷଣମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୩] ଔଷଧର ପ୍ରଭାବ ୭ ଦିନ ମଧ୍ୟରେ ଆରମ୍ଭ ହୁଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଶୁଖିଲା ପାଟି, ପେଟ ଯନ୍ତ୍ରଣା ଏବଂ କୋଷ୍ଠକାଠିନ୍ୟ ହୋଇପାରେ ।^[୩] ^[୪] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୂତ୍ର ଧାରଣ, ଉତ୍ତେଜନା ଏବଂ ଆନାଫାଇଲକ୍ସିସ୍ ହୋଇପାରେ ।^[୩] ^[୪] ଗର୍ଭାବସ୍ଥାରେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୫] ଏହା ଏକ <a href="./Antimuscarinic_agent" rel="mw:WikiLink" data-linkid="164" class="new cx-link" data-mw-i18n="{"title":{"lang":"x-page","key":"red-link-title","params":["Antimuscarinic agent"]}}" id="mwIQ" title="Antimuscarinic agent" typeof="mw:LocalizedAttrs">ଆଣ୍ଟିମ୍ୟୁସ୍କାରିନିକ୍ ଏଜେଣ୍ଟ</a> ଯାହାର ପ୍ରଭାବ କେନ୍ଦ୍ରୀୟ ସ୍ନାୟୁ ପ୍ରଣାଳୀରେ ସାମାନ୍ୟ ରହେ ।^[୬] ଏହା ବ୍ଲାଡରର ସୁଗମ ମାଂସପେଶୀକୁ ଆରାମ ଦେଇ କାମ କରେ | ^[୭]

୧୯୬୬ରେ ଟ୍ରୋସପିୟମ୍ ପ୍ୟାଟେଣ୍ଟ୍ ହୋଇଥିଲା ଏବଂ ୧୯୭୪ରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୮] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ । ^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ଏକ ମାସର ଔଷଧ ଖର୍ଚ୍ଚ ୨୦୨୧ରେ ପ୍ରାୟ £୬ ଥିଲା ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୩୦ ଡଲାର ଥିଲା ।^[୯]

ଆଧାର

↑ Drugs.com international brands of trospium Archived 2019-10-22 at the Wayback Machine. Page accessed May 13, 2016
↑ ^୨.୦ ^୨.୧ Kreder, Karl; Dmochowski, Roger (10 July 2007). The Overactive Bladder: Evaluation and Management (in ଇଂରାଜୀ). CRC Press. p. 193. ISBN 978-0-203-93162-2. Archived from the original on 23 September 2021. Retrieved 20 September 2021.
↑ ^୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Trospium Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 20 September 2021.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 824. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ "Trospium Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 20 September 2021.
↑ Biastre K, Burnakis T (February 2009). "Trospium chloride treatment of overactive bladder". Ann Pharmacother. 43 (2): 283–95. doi:10.1345/aph.1L160. PMID 19193592.
↑ "Regurin XL 60mg - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 17 January 2021. Retrieved 20 September 2021.
↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 446. ISBN 9783527607495. Archived from the original on 2020-11-15. Retrieved 2021-03-16.
↑ "Trospium Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 April 2021. Retrieved 20 September 2021.

[brands-1] Drugs.com international brands of trospium Archived 2019-10-22 at the Wayback Machine. Page accessed May 13, 2016

[Rog2007-2] ୨.୦ ^୨.୧ Kreder, Karl; Dmochowski, Roger (10 July 2007). The Overactive Bladder: Evaluation and Management (in ଇଂରାଜୀ). CRC Press. p. 193. ISBN 978-0-203-93162-2. Archived from the original on 23 September 2021. Retrieved 20 September 2021.

[AHFS2021-3] ୩.୦ ^୩.୧ ^୩.୨ ^୩.୩ "Trospium Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 20 September 2021.

[BNF80-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 824. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[5] "Trospium Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 3 December 2020. Retrieved 20 September 2021.

[2009rev-6] Biastre K, Burnakis T (February 2009). "Trospium chloride treatment of overactive bladder". Ann Pharmacother. 43 (2): 283–95. doi:10.1345/aph.1L160. PMID 19193592.

[emcXLlabel-7] "Regurin XL 60mg - Summary of Product Characteristics (SmPC) - (emc)". www.medicines.org.uk. Archived from the original on 17 January 2021. Retrieved 20 September 2021.

[8] Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 446. ISBN 9783527607495. Archived from the original on 2020-11-15. Retrieved 2021-03-16.

[9] "Trospium Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 April 2021. Retrieved 20 September 2021.

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Clinical data

Trade names	Regurin, Sanctura, others^[୧]
AHFS/Drugs.com	monograph
Pregnancy category	C
Routes of administration	By mouth (tablets, capsules)
Legal status
Legal status	℞ (Prescription only)
Pharmacokinetic data
Protein binding	50–85%
Onset of action	Within 7 days^[୨]
Elimination half-life	20 hours
Identifiers
IUPAC name 3‑(2‑Hydroxy-2,2‑diphenylacetoxy)spiro[bicyclo[3.2.1]octane-8,1'‑pyrrolidin]-1'‑ium chloride
ECHA InfoCard	100.030.784
Chemical and physical data
Formula	C₂₅H₃₀ClNO₃
Molar mass	୪୨୭.୯୭ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES OC(c1ccccc1)(c2ccccc2)C(=O)O[C@@H]3C[C@@H]5CC[C@H](C3)[N+]45CCCC4
InChI InChI=1S/C25H30NO3/c27-24(25(28,19-9-3-1-4-10-19)20-11-5-2-6-12-20)29-23-17-21-13-14-22(18-23)26(21)15-7-8-16-26/h1-6,9-12,21-23,28H,7-8,13-18H2/q+1/t21-,22+,23+^Y Key:OYYDSUSKLWTMMQ-JKHIJQBDSA-N^Y
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