ଟ୍ରାଇଫାରୋଟିନ

ଟ୍ରାଇଫାରୋଟିନ
Clinical data
Trade names	Aklief
Synonyms	CD5789
AHFS/Drugs.com	monograph
MedlinePlus	a620004
data	US DailyMed: Trifarotene;
Pregnancy; category	AU: D ; Contraindicated;
Routes of; administration	Topical
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; US: ℞-only ;
Identifiers
	IUPAC name 4-[3-(3-tert-Butyl-4-pyrrolidin-1-ylphenyl)-4-(2-hydroxyethoxy)phenyl]benzoic acid;
ECHA InfoCard	100.278.901
Chemical and physical data
Formula	C29H33NO4
Molar mass	୪୫୯.୫୯ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)(C)C1=C(C=CC(=C1)C2=C(C=CC(=C2)C3=CC=C(C=C3)C(=O)O)OCCO)N4CCCC4;
	InChI InChI=1S/C29H33NO4/c1-29(2,3)25-19-23(10-12-26(25)30-14-4-5-15-30)24-18-22(11-13-27(24)34-17-16-31)20-6-8-21(9-7-20)28(32)33/h6-13,18-19,31H,4-5,14-17H2,1-3H3,(H,32,33); Key:MFBCDACCJCDGBA-UHFFFAOYSA-N;

ଟ୍ରାଇଫାରୋଟିନ, (ଇଂରାଜୀ ଭାଷାରେ Trifarotene), ଆକ୍ଲିଫ୍ ଏହାର ବେପାର ନାମ, ହେଉଛି ବ୍ରଣ ପାଇଁ ବ୍ୟବହୃତ ଏକ ଔଷଧ ।^[୪] ଏହା ଚର୍ମରେ ମଲମ ଭାବରେ ପ୍ରୟୋଗ କରାଯାଏ ।^[୪] ଚର୍ମର ଉତ୍ତେଜନାକୁ ରୋକିବାରେ ମଏଶ୍ଚରାଇଜର ବା ଓଦା କରିବା ସାମଗ୍ରୀ ମଧ୍ୟ ବ୍ୟବହୃତ ହୋଇପାରେ ।^[୪]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗଲୁ, ଉତ୍ତେଜନା ଏବଂ ସହଜ ଆତପଦାହ ହୋଇପାରେ ।^[୪] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୫] ଏହା ଏକ ରେଟିନଏଡ୍; ବିଶେଷ ଭାବରେ ଏକ ଚତୁର୍ଥ ପିଢ଼ୀର ସିଲେକ୍ଟିଭ୍ ରେଟିନୋଇକ ଏସିଡ ରିସେପ୍ଟର ଗାମା (RAR-γ) ଆଗୋନିଷ୍ଟ ।^[୪] ^[୬]

୨୦୧୯ ମସିହାରେ ଆମେରିକା, କାନାଡ଼ା ଏବଂ ୟୁରୋପରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଟ୍ରାଇଫାରୋଟିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୪] ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୧ ସୁଦ୍ଧା ୪୫ ଗ୍ରାମ ଔଷଧ ନଳୀର (tube) ମୂଲ୍ୟ ପ୍ରାୟ ୫୭୫ ଡଲାର ଥିଲା ।^[୭]

ଆଧାର

↑ ^୧.୦ ^୧.୧ "Trifarotene Product Information". Therapeutic Goods Administration (TGA). Archived from the original on 23 May 2021. Retrieved 23 May 2021.
↑ "Archive copy" (PDF). Archived (PDF) from the original on 23 May 2021. Retrieved 26 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)
↑ "Aklief- trifarotene cream". DailyMed. Archived from the original on 23 May 2021. Retrieved 22 May 2021.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Trifarotene Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2021. Retrieved 19 September 2021.
↑ ^୫.୦ ^୫.୧ "Australian Public Assessment Report for Trifarotene" (PDF). Archived (PDF) from the original on 23 September 2021. Retrieved 19 September 2021.
↑ Scott LJ (November 2019). "Trifarotene: First Approval". Drugs. 79 (17): 1905–1909. doi:10.1007/s40265-019-01218-6. PMID 31713811. Archived from the original on 29 August 2021. Retrieved 26 June 2021.
↑ "Aklief Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.

[Aklief_TGA_label-1] ୧.୦ ^୧.୧ "Trifarotene Product Information". Therapeutic Goods Administration (TGA). Archived from the original on 23 May 2021. Retrieved 23 May 2021.

[Aklief_Health_Canada_label-2] "Archive copy" (PDF). Archived (PDF) from the original on 23 May 2021. Retrieved 26 June 2021.{{cite web}}: CS1 maint: archived copy as title (link)

[Aklief_FDA_label-3] "Aklief- trifarotene cream". DailyMed. Archived from the original on 23 May 2021. Retrieved 22 May 2021.

[AHFS2021-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Trifarotene Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 4 March 2021. Retrieved 19 September 2021.

[TGA2021-5] ୫.୦ ^୫.୧ "Australian Public Assessment Report for Trifarotene" (PDF). Archived (PDF) from the original on 23 September 2021. Retrieved 19 September 2021.

[Scott2019-6] Scott LJ (November 2019). "Trifarotene: First Approval". Drugs. 79 (17): 1905–1909. doi:10.1007/s40265-019-01218-6. PMID 31713811. Archived from the original on 29 August 2021. Retrieved 26 June 2021.

[7] "Aklief Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 19 September 2021.

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