ଗୋଲିମୁମାବ

ଗୋଲିମୁମାବ
	Cartoon representation of the antibody Golimumab. The heavy and light chains are coloured blue and yellow respectively. From PDB entry ଛାଞ୍ଚ:PDBe
Monoclonal antibody
Type	Whole antibody
Source	Human
Target	TNFα
Clinical data
Trade names	Simponi, Simponi Aria
Synonyms	CNTO-148
AHFS/Drugs.com	monograph
MedlinePlus	a610010
data	EU EMA: yes; US DailyMed: Golimumab;
Pregnancy; category	AU: C ; US: N (Not classified yet) ; ;
Routes of; administration	Subcutaneous injection
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ;
Identifiers
ECHA InfoCard	100.226.360
Chemical and physical data
Formula	C6530H10068N1752O2026S44
Molar mass	୧,୪୬,୯୪୫.୨୫ g·mol−1
(verify)

ଗୋଲିମୁମାବ, ସିମ୍ପୋନି ଏକ ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ରିଉମାଟଏଡ ଆର୍ଥ୍ରାଇଟିସ, ଜୁଭେନାଇଲ ଇଡିଓପାଥିକ ଆର୍ଥ୍ରାଇଟିସ, ସୋରିୟାଟିକ୍ ଗଣ୍ଠି ପ୍ରଦାହ, ଆଙ୍କିଲୋଜିଙ୍ଗ ସ୍ପଣ୍ଡିଲାଇଟିସ ଏବଂ ଅଲସରେଟିଭ କୋଲାଇଟିସର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ^[୨] ଚର୍ମ ତଳେ ଇଞ୍ଜେକସନ ଆକାରରେ ଏହା ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ରର୍ଦ୍ଧ୍ୱ ଶ୍ୱାସନଳୀ ସଂକ୍ରମଣ ହୋଇପାରେ । ^[୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ସେପ୍ସିସ, ନିମୋନିଆ, ହେପାଟାଇଟିସ୍ ବିର ପୁନଃ ସକ୍ରିୟତା, ହୃଦ୍‌ପାତ, ଆଲର୍ଜି ପ୍ରତିକ୍ରିୟା, ଭାସ୍କୁଲାଇଟିସ ଏବଂ ଲିଉକେମିଆ ଅନ୍ତର୍ଭୁକ୍ତ ହୋଇପାରେ ।^[୨] ଗର୍ଭାବସ୍ଥାରେ ଏବଂ ସ୍ତନ୍ୟପାନ ସମୟରେ ବ୍ୟବହାର କଲେ ସୁରକ୍ଷା ଅସ୍ପଷ୍ଟ ଅଟେ ।^[୬] ଏହା ଏକ ମୋନୋକ୍ଲୋନାଲ ଆଣ୍ଟିବଡି ଯାହା ଟ୍ୟୁମର ନେକ୍ରୋସିସ୍ ଫ୍ୟାକ୍ଟର୍ ଆଲଫା (TNF-alpha) ନାମକ ଏକ ପ୍ରୋ-ଇନ୍‌ଫ୍ଲାମେଟୋରୀ ଅଣୁ ସହିତ ସଂଲଗ୍ନ ହୋଇ ତାହାକୁ ଅବରୋଧ କରେ ।^[୨]

୨୦୦୯ ମସିହାରେ ଆମେରିକା ଏବଂ ୟୁରୋପରେ ଡାକ୍ତରୀ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ ଗୋଲିମୁମାବକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୫] ^[୨] ଆଡାଲିମୁମାବର ବିକଳ୍ପ ଭାବରେ ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଜରୁରୀ ଔଷଧ ତାଲିକାରେ ଏହାର ନାମ ଲିପିବଦ୍ଧ ଅଛି ।^[୭] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୧୦୦ମିଗ୍ରା ଔଷଧର ମୂଲ୍ୟ ପ୍ରାୟ ୧୫୦୦ ପାଉଣ୍ଡ ଡଲାର ଥିଲା ।^[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୬୩୦୦ ଡଲାର ଅଟେ ।^[୯]

ଆଧାର

↑ Mazumdar S, Greenwald D (2009). "Golimumab". mAbs. 1 (5): 422–31. doi:10.4161/mabs.1.5.9286. PMC 2759491. PMID 20065639. Archived from the original on 2014-08-08. Retrieved 2021-10-04.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Simponi EPAR". European Medicines Agency (EMA). Archived from the original on 11 November 2020. Retrieved 11 November 2020.
↑ "Simponi- golimumab injection, solution". DailyMed. 30 September 2019. Archived from the original on 25 March 2021. Retrieved 11 November 2020.
↑ "Simponi Aria- golimumab solution". DailyMed. 2 October 2020. Archived from the original on 24 March 2021. Retrieved 11 November 2020.
↑ ^୫.୦ ^୫.୧ ^୫.୨ "Golimumab Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 July 2018. Retrieved 9 December 2021.
↑ "Golimumab Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 9 December 2021.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1162. ISBN 978-0857114105.
↑ "Simponi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 9 December 2021.

[1] Mazumdar S, Greenwald D (2009). "Golimumab". mAbs. 1 (5): 422–31. doi:10.4161/mabs.1.5.9286. PMC 2759491. PMID 20065639. Archived from the original on 2014-08-08. Retrieved 2021-10-04.

[EPAR2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ "Simponi EPAR". European Medicines Agency (EMA). Archived from the original on 11 November 2020. Retrieved 11 November 2020.

[3] "Simponi- golimumab injection, solution". DailyMed. 30 September 2019. Archived from the original on 25 March 2021. Retrieved 11 November 2020.

[4] "Simponi Aria- golimumab solution". DailyMed. 2 October 2020. Archived from the original on 24 March 2021. Retrieved 11 November 2020.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ "Golimumab Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 9 July 2018. Retrieved 9 December 2021.

[6] "Golimumab Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 29 October 2020. Retrieved 9 December 2021.

[WHO22nd-7] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[BNF81-8] BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1162. ISBN 978-0857114105.

[9] "Simponi Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 20 January 2021. Retrieved 9 December 2021.

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