କ୍ଲେଭିଡିପିନ

କ୍ଲେଭିଡିପିନ
Clinical data
Trade names	Cleviprex
AHFS/Drugs.com	monograph
data	US DailyMed: Clevidipine;
Routes of; administration	Intravenous
Legal status
Legal status	US: ℞-only ; EU: Rx-only ;
Pharmacokinetic data
Bioavailability	100% (used only IV)
Protein binding	>99.5%
Metabolism	Blood and tissue esterases
Onset of action	With 4 min
Elimination half-life	1 minute
Duration of action	Up to 15 min
Excretion	Urine (63–74%), feces (7–22%)
Identifiers
	IUPAC name (RS)-5-O-(Butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;
ECHA InfoCard	100.208.117
Chemical and physical data
Formula	C21H23Cl2NO6
Molar mass	୪୫୬.୩୨ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCOC(=O)CCC)\C1=C(\N/C(=C(/C(=O)OC)[C@H]1c2cccc(Cl)c2Cl)C)C;

କ୍ଲେଭିଡିପିନ, କ୍ଲିଭିପ୍ରେକ୍ସ ଏହାର ବେପାର ନାମ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଉଚ୍ଚ ରକ୍ତଚାପର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଉଚ୍ଚ ରକ୍ତଚାପ ଜରୁରୀକାଳୀନ ପରିସ୍ଥିତିରେ ଏବଂ ଅସ୍ତ୍ରୋପଚାର ସମୟରେ ଏହା ଦିଆଯାଏ ।^[୨] ଏହା ଏକ ଶିରାରେ ଇଞ୍ଜେକସନ ଆକାରରେ ଦିଆଯାଏ ।^[୨] ପ୍ରଭାବ 4 ମିନିଟ ମଧ୍ୟରେ ଆରମ୍ଭ ହୋଇ ୧୫ ମିନିଟ୍ ପର୍ଯ୍ୟନ୍ତ ରହିଥାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମୁଣ୍ଡବିନ୍ଧା ଏବଂ ଅଇ ଲାଗେ ।^[୩] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ନିମ୍ନ ରକ୍ତଚାପ, ଦ୍ରୁତ ହୃଦସ୍ପନ୍ଦନ ଏବଂ ଖରାପ ଦିଗକୁ ହୃଦ୍‌ପାତ ଯାଇପାରେ ।^[୩] ଅଣ୍ଡା କିମ୍ବା ସୋୟା ଆଲର୍ଜି ଥିବା ଲୋକଙ୍କୁ ଏହା ବ୍ୟବହାର କରିବାକୁ ଦେବା ଉଚିତ୍ ନୁହେଁ ।^[୩] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।^[୪] ଏହା ଡିହାଇଡ୍ରୋପାଇରିଡିନ ପ୍ରକାରର ଏକ କ୍ୟାଲସିୟମ୍ ଚ୍ୟାନେଲ୍ ବ୍ଲକର୍ ।^[୨]

୨୦୦୮ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା କ୍ଷେତ୍ରରେ ବ୍ୟବହାର ପାଇଁ କ୍ଲେଭିଡିପିନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ଏହା ଅନେକ ୟୁରୋପୀୟ ଦେଶରେ ମଧ୍ୟ ଉପଲବ୍ଧ । ^[୫] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ୨୦୨୨ ସୁଦ୍ଧା ୫୦ ମିଗ୍ରାର ମୂଲ୍ୟ ୧୬୦ ଡଲାର ଥିଲା ।^[୬]

ଆଧାର ସମ୍ପାଦନା

↑ "Archive copy" (PDF). Archived (PDF) from the original on 2021-11-02. Retrieved 2021-10-31.{{cite web}}: CS1 maint: archived copy as title (link)
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Clevidipine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 June 2021. Retrieved 5 January 2022.
↑ ^୩.୦ ^୩.୧ ^୩.୨ "DailyMed - CLEVIPREX- clevidipine emulsion". dailymed.nlm.nih.gov. Archived from the original on 2 March 2021. Retrieved 5 January 2022.
↑ "Clevidipine (Cleviprex) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 November 2020. Retrieved 5 January 2022.
↑ "List of nationally authorised medicinal products" (PDF). Archived (PDF) from the original on 5 July 2019. Retrieved 5 January 2022.
↑ "Cleviprex Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 5 January 2022.

[1] "Archive copy" (PDF). Archived (PDF) from the original on 2021-11-02. Retrieved 2021-10-31.{{cite web}}: CS1 maint: archived copy as title (link)

[AHFS2022-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Clevidipine Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 10 June 2021. Retrieved 5 January 2022.

[PI2022-3] ୩.୦ ^୩.୧ ^୩.୨ "DailyMed - CLEVIPREX- clevidipine emulsion". dailymed.nlm.nih.gov. Archived from the original on 2 March 2021. Retrieved 5 January 2022.

[4] "Clevidipine (Cleviprex) Use During Pregnancy". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 26 November 2020. Retrieved 5 January 2022.

[5] "List of nationally authorised medicinal products" (PDF). Archived (PDF) from the original on 5 July 2019. Retrieved 5 January 2022.

[6] "Cleviprex Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 18 January 2021. Retrieved 5 January 2022.

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